Inhibitory effects of Saussurea involucrata against melanogenesis of mouse-derived melanocyte cells

Qing Mu, Hyun Jung Choi, Li Fei Wang, Xiao Jin Li, Jae Sung Hwang, Byeong Gon Lee, Jia Ye, Bi Yan Zhang, Yin Jin Sun, Nam Hoon Cho, Sang Jun Lee, Young Chul Sim

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Abstract

Extracts and fractions from the aerial parts of herbal materials of Saussurea involucrata Kar et Kir ex Maxim (Compositae) were investigated for their whitening activity against mouse-derived immortalized melanocyte cell line. The extract of wild herbs (FS2) possessed a better inhibition (28.2% growth) against melanin cells than that (46.7%) of cultivated herbs (FS1). The whole extracts and middle-polar partitioning fraction show the inhibitory effects, whereas the water-soluble parts show a poor activity in the same assay.

Original languageEnglish
Pages (from-to)678-682
Number of pages5
JournalPharmaceutical Biology
Volume45
Issue number9
DOIs
Publication statusPublished - 2007 Nov 1

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All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

Cite this

Mu, Q., Choi, H. J., Wang, L. F., Li, X. J., Hwang, J. S., Lee, B. G., Ye, J., Zhang, B. Y., Sun, Y. J., Cho, N. H., Lee, S. J., & Sim, Y. C. (2007). Inhibitory effects of Saussurea involucrata against melanogenesis of mouse-derived melanocyte cells. Pharmaceutical Biology, 45(9), 678-682. https://doi.org/10.1080/13880200701574950