Initial motor reserve and long-term prognosis in Parkinson's disease

Seok Jong Chung, Han Soo Yoo, Yang Hyun Lee, Hye Sun Lee, Phil Hyu Lee, Young H. Sohn

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1 Citation (Scopus)

Abstract

There are individual differences in motor deficits, despite a similar degree of dopamine neuronal loss in Parkinson's disease (PD), called motor reserve (MR). Factors enhancing MR have been documented previously, but the influence of initial MR on the long-term prognosis remains unclear. In this longitudinal study, we enrolled 205 patients with de novo PD to estimate individual MR based on initial motor deficits and striatal dopamine depletion using the residual-based approach. We assessed the risk of developing levodopa-induced dyskinesia (LID) or freezing of gait (FOG) and longitudinal increases in levodopa-equivalent dose (LED) according to MR estimates using the Cox regression model and linear mixed model, respectively. Throughout the follow-up period (≥3 years), greater MR estimates were associated with a lower risk for LID and FOG. In addition, patients with high MR received lower LED than those with low MR. These findings suggest that the initial MR, that is, individual's capacity to cope with PD-related pathologies, can be maintained with disease progression and can modulate the risk for LID or FOG.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalNeurobiology of Aging
Volume92
DOIs
Publication statusPublished - 2020 Aug

Bibliographical note

Funding Information:
This study was supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education (grant number: NRF-2018R1D1A1B07048959). The funder had no role in study design, data collection and analysis, the decision to publish, or manuscript preparation. The authors thank Jungsu S. Oh and Jae Seung Kim (Department of Nuclear Medicine, Asan Medical Center, University Ulsan College of Medicine, Seoul, South Korea) for the quantitative analyses of FP-CIT PET images. Seok Jong Chung: Conceptualization, Methodology, Formal analysis, Investigation, Writing - original draft, Funding acquisition. Han Soo Yoo: Formal analysis, Validation, Writing - review and editing. Yang Hyun Lee: Validation, Writing - review and editing. Hye Sun Lee: Formal analysis, Methodology, Validation, Writing - review and editing. Phil Hyu Lee: Data curation, Resources, Supervision, Validation, Writing - review and editing. Young H. Sohn: Conceptualization, Data curation, Investigation, Project administration, Resources, Supervision, Validation, Writing - original draft.

Funding Information:
This study was supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education (grant number: NRF-2018R1D1A1B07048959 ). The funder had no role in study design, data collection and analysis, the decision to publish, or manuscript preparation. The authors thank Jungsu S. Oh and Jae Seung Kim (Department of Nuclear Medicine, Asan Medical Center, University Ulsan College of Medicine, Seoul, South Korea) for the quantitative analyses of FP-CIT PET images.

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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