Initial study on in vivo conductivity mapping of breast cancer using MRI

Jaewook Shin, minjung Kim, Joonsung Lee, Yoonho Nam, Min Oh Kim, Narae Choi, Sooyeon Kim, Donghyun Kim

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Purpose To develop and apply a method to measure in vivo electrical conductivity values using magnetic resonance imaging (MRI) in subjects with breast cancer. Materials and Methods A recently developed technique named MREPT (MR electrical properties tomography) together with a novel coil combination process was used to quantify the conductivity values. The overall technique was validated using a phantom study. In addition, 90 subjects were imaged (50 subjects with previously biopsy-confirmed breast tumor and 40 normal subjects), which was approved by our institutional review board (IRB). A routine clinical protocol, specifically a T2-weighted FSE (fast spin echo) imaging data, was used for reconstruction of conductivity. Results By employing the coil combination, the relative error in the conductivity map was reduced from ∼70% to 10%. The average conductivity values in breast cancers regions (0.89-±-0.33S/m) was higher compared to parenchymal tissue (0.43 S/m, P < 0.0001) and fat (0.07 S/m, P < 0.00005) regions. Malignant cases (0.89 S/m, n = 30) showed increased conductivity compared to benign cases (0.56 S/m, n = 5) (P < 0.05). In addition, invasive cancers (0.96 S/m) showed higher mean conductivity compared to in situ cancers (0.57 S/m) (P < 0.0005). Conclusion This study shows that conductivity mapping of breast cancers is feasible using a noninvasive in vivo MREPT technique combined with a coil combination process. The method may provide a tool in the MR diagnosis of breast cancer.

Original languageEnglish
Pages (from-to)371-378
Number of pages8
JournalJournal of Magnetic Resonance Imaging
Volume42
Issue number2
DOIs
Publication statusPublished - 2015 Jan 1

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Magnetic Resonance Imaging
Breast Neoplasms
Tomography
Electric Conductivity
Research Ethics Committees
Clinical Protocols
Neoplasms
Fats
Biopsy

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Shin, Jaewook ; Kim, minjung ; Lee, Joonsung ; Nam, Yoonho ; Kim, Min Oh ; Choi, Narae ; Kim, Sooyeon ; Kim, Donghyun. / Initial study on in vivo conductivity mapping of breast cancer using MRI. In: Journal of Magnetic Resonance Imaging. 2015 ; Vol. 42, No. 2. pp. 371-378.
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abstract = "Purpose To develop and apply a method to measure in vivo electrical conductivity values using magnetic resonance imaging (MRI) in subjects with breast cancer. Materials and Methods A recently developed technique named MREPT (MR electrical properties tomography) together with a novel coil combination process was used to quantify the conductivity values. The overall technique was validated using a phantom study. In addition, 90 subjects were imaged (50 subjects with previously biopsy-confirmed breast tumor and 40 normal subjects), which was approved by our institutional review board (IRB). A routine clinical protocol, specifically a T2-weighted FSE (fast spin echo) imaging data, was used for reconstruction of conductivity. Results By employing the coil combination, the relative error in the conductivity map was reduced from ∼70{\%} to 10{\%}. The average conductivity values in breast cancers regions (0.89-±-0.33S/m) was higher compared to parenchymal tissue (0.43 S/m, P < 0.0001) and fat (0.07 S/m, P < 0.00005) regions. Malignant cases (0.89 S/m, n = 30) showed increased conductivity compared to benign cases (0.56 S/m, n = 5) (P < 0.05). In addition, invasive cancers (0.96 S/m) showed higher mean conductivity compared to in situ cancers (0.57 S/m) (P < 0.0005). Conclusion This study shows that conductivity mapping of breast cancers is feasible using a noninvasive in vivo MREPT technique combined with a coil combination process. The method may provide a tool in the MR diagnosis of breast cancer.",
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Initial study on in vivo conductivity mapping of breast cancer using MRI. / Shin, Jaewook; Kim, minjung; Lee, Joonsung; Nam, Yoonho; Kim, Min Oh; Choi, Narae; Kim, Sooyeon; Kim, Donghyun.

In: Journal of Magnetic Resonance Imaging, Vol. 42, No. 2, 01.01.2015, p. 371-378.

Research output: Contribution to journalArticle

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AU - Shin, Jaewook

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AU - Choi, Narae

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AU - Kim, Donghyun

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N2 - Purpose To develop and apply a method to measure in vivo electrical conductivity values using magnetic resonance imaging (MRI) in subjects with breast cancer. Materials and Methods A recently developed technique named MREPT (MR electrical properties tomography) together with a novel coil combination process was used to quantify the conductivity values. The overall technique was validated using a phantom study. In addition, 90 subjects were imaged (50 subjects with previously biopsy-confirmed breast tumor and 40 normal subjects), which was approved by our institutional review board (IRB). A routine clinical protocol, specifically a T2-weighted FSE (fast spin echo) imaging data, was used for reconstruction of conductivity. Results By employing the coil combination, the relative error in the conductivity map was reduced from ∼70% to 10%. The average conductivity values in breast cancers regions (0.89-±-0.33S/m) was higher compared to parenchymal tissue (0.43 S/m, P < 0.0001) and fat (0.07 S/m, P < 0.00005) regions. Malignant cases (0.89 S/m, n = 30) showed increased conductivity compared to benign cases (0.56 S/m, n = 5) (P < 0.05). In addition, invasive cancers (0.96 S/m) showed higher mean conductivity compared to in situ cancers (0.57 S/m) (P < 0.0005). Conclusion This study shows that conductivity mapping of breast cancers is feasible using a noninvasive in vivo MREPT technique combined with a coil combination process. The method may provide a tool in the MR diagnosis of breast cancer.

AB - Purpose To develop and apply a method to measure in vivo electrical conductivity values using magnetic resonance imaging (MRI) in subjects with breast cancer. Materials and Methods A recently developed technique named MREPT (MR electrical properties tomography) together with a novel coil combination process was used to quantify the conductivity values. The overall technique was validated using a phantom study. In addition, 90 subjects were imaged (50 subjects with previously biopsy-confirmed breast tumor and 40 normal subjects), which was approved by our institutional review board (IRB). A routine clinical protocol, specifically a T2-weighted FSE (fast spin echo) imaging data, was used for reconstruction of conductivity. Results By employing the coil combination, the relative error in the conductivity map was reduced from ∼70% to 10%. The average conductivity values in breast cancers regions (0.89-±-0.33S/m) was higher compared to parenchymal tissue (0.43 S/m, P < 0.0001) and fat (0.07 S/m, P < 0.00005) regions. Malignant cases (0.89 S/m, n = 30) showed increased conductivity compared to benign cases (0.56 S/m, n = 5) (P < 0.05). In addition, invasive cancers (0.96 S/m) showed higher mean conductivity compared to in situ cancers (0.57 S/m) (P < 0.0005). Conclusion This study shows that conductivity mapping of breast cancers is feasible using a noninvasive in vivo MREPT technique combined with a coil combination process. The method may provide a tool in the MR diagnosis of breast cancer.

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