Injectable bone using chitosan-alginate gel/mesenchymal stem cells/BMP-2 composites

Dongjoon Park, Byungho Choi, Shi Jiang Zhu, Jin Young Huh, Byung Young Kim, Seoung Ho Lee

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

Aim: Several injectable materials have been used as osteogenic bone substitutes. However, none has gained universal acceptance. This study was performed to investigate whether or not chitosan-alginate gel/mesenchymal stem cells/bone morphogenetic protein-2 composites are potentially injectable materials for new bone formation. Material and methods: The composites were injected into the subcutaneous space on the dorsum of nude mice to investigate new bone tissue formation. The composites were examined histologically over a 12-week period. Results: The composites injected into the mouse were able to stimulate new bone formation, which was trabecular in type. Conclusions: This study showed that chitosan-alginate gel/MSCs/BMP-2 composites could become clinically useful injectable materials to generate new bone.

Original languageEnglish
Pages (from-to)50-54
Number of pages5
JournalJournal of Cranio-Maxillofacial Surgery
Volume33
Issue number1
DOIs
Publication statusPublished - 2005 Feb 1

Fingerprint

Chitosan
Mesenchymal Stromal Cells
Osteogenesis
Gels
Bone and Bones
Injections
Bone Substitutes
Bone Morphogenetic Protein 2
Nude Mice
alginic acid

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology

Cite this

Park, Dongjoon ; Choi, Byungho ; Zhu, Shi Jiang ; Huh, Jin Young ; Kim, Byung Young ; Lee, Seoung Ho. / Injectable bone using chitosan-alginate gel/mesenchymal stem cells/BMP-2 composites. In: Journal of Cranio-Maxillofacial Surgery. 2005 ; Vol. 33, No. 1. pp. 50-54.
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Injectable bone using chitosan-alginate gel/mesenchymal stem cells/BMP-2 composites. / Park, Dongjoon; Choi, Byungho; Zhu, Shi Jiang; Huh, Jin Young; Kim, Byung Young; Lee, Seoung Ho.

In: Journal of Cranio-Maxillofacial Surgery, Vol. 33, No. 1, 01.02.2005, p. 50-54.

Research output: Contribution to journalArticle

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T1 - Injectable bone using chitosan-alginate gel/mesenchymal stem cells/BMP-2 composites

AU - Park, Dongjoon

AU - Choi, Byungho

AU - Zhu, Shi Jiang

AU - Huh, Jin Young

AU - Kim, Byung Young

AU - Lee, Seoung Ho

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AB - Aim: Several injectable materials have been used as osteogenic bone substitutes. However, none has gained universal acceptance. This study was performed to investigate whether or not chitosan-alginate gel/mesenchymal stem cells/bone morphogenetic protein-2 composites are potentially injectable materials for new bone formation. Material and methods: The composites were injected into the subcutaneous space on the dorsum of nude mice to investigate new bone tissue formation. The composites were examined histologically over a 12-week period. Results: The composites injected into the mouse were able to stimulate new bone formation, which was trabecular in type. Conclusions: This study showed that chitosan-alginate gel/MSCs/BMP-2 composites could become clinically useful injectable materials to generate new bone.

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