iNKT cells suppress pathogenic NK1.1CD8+ T cells in DSS-induced colitis

Sung Won Lee, Hyun Jung Park, Jae Hee Cheon, Lan Wu, Luc Van Kaer, Seokmann Hong

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8 Citations (Scopus)

Abstract

T cells producing IFNγ play a pathogenic role in the development of inflammatory bowel disease (IBD). To investigate the functions of CD1d-dependent invariant natural killer T (iNKT) cells in experimental colitis induced in Yeti mice with dysregulated expression of IFNγ, we generated iNKT cell-deficient Yeti/CD1d KO mice and compared colitis among WT, CD1d KO, Yeti, and Yeti/CD1d KO mice following DSS treatment. We found that deficiency of iNKT cells exacerbated colitis and disease pathogenesis was mainly mediated by NK1.1+CD8+ T cells. Furthermore, the protective effects of iNKT cells correlated with up-regulation of regulatory T cells. Taken together, our results have demonstrated that CD1d-dependent iNKT cells and CD1d-independent NK1.1+CD8+ T cells reciprocally regulate the development of intestinal inflammatory responses mediated by IFNγ-dysregulation. These findings also identify NK1.1+CD8+ T cells as novel target cells for the development of therapeutics for human IBD.

Original languageEnglish
Article number2168
JournalFrontiers in Immunology
Volume9
Issue numberOCT
DOIs
Publication statusPublished - 2018 Oct 2

Bibliographical note

Funding Information:
This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI18C0094010018) and Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education (2018R1D1A1B07049495).

Publisher Copyright:
© 2018 Lee, Park, Cheon, Wu, Van Kaer and Hong.

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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