Insect bite-like reaction with bullous lesions mimicking bullous pemphigoid in a patient with chronic lymphocytic leukemia

Jee Eun Kim, Soo Chan Kim

Research output: Contribution to journalArticle

Abstract

Patients with chronic lymphocytic leukemia (CLL) rarely exhibit an exaggerated insect bite-like reaction without a history of an arthropod bite. We report a case of an insect bite-like reaction in a 74-year old man with CLL. The patient presented with a 2-year history of recurrent itchy erythematous patches and blisters on the whole body. He had been diagnosed with CLL 2 years ago, and the skin lesions developed 1 month after remission. The result of a skin biopsy was consistent with insect bite. Immunohistochemical staining of the infiltrated cells showed positive reactions for CD3, CD5 and negative for CD20, CD23. Direct and indirect immunofluorescence revealed negative results. The patient was treated with oral prednisolone and dapsone, under the diagnosis of CLL-associated insect bite-like reaction, and showed marked improvement. Dermatologist should be aware of insect bite-like reaction associated with CLL as a distinct disease entity that is similar to insect bite or bullous pemphigoid.

Original languageEnglish
Pages (from-to)468-472
Number of pages5
JournalAnnals of Dermatology
Volume30
Issue number4
DOIs
Publication statusPublished - 2018 Aug

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Insect Bites and Stings
Bullous Pemphigoid
B-Cell Chronic Lymphocytic Leukemia
Blister
Dapsone
Direct Fluorescent Antibody Technique
Skin
Arthropods
Bites and Stings
Indirect Fluorescent Antibody Technique
Prednisolone
Staining and Labeling
Biopsy

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

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abstract = "Patients with chronic lymphocytic leukemia (CLL) rarely exhibit an exaggerated insect bite-like reaction without a history of an arthropod bite. We report a case of an insect bite-like reaction in a 74-year old man with CLL. The patient presented with a 2-year history of recurrent itchy erythematous patches and blisters on the whole body. He had been diagnosed with CLL 2 years ago, and the skin lesions developed 1 month after remission. The result of a skin biopsy was consistent with insect bite. Immunohistochemical staining of the infiltrated cells showed positive reactions for CD3, CD5 and negative for CD20, CD23. Direct and indirect immunofluorescence revealed negative results. The patient was treated with oral prednisolone and dapsone, under the diagnosis of CLL-associated insect bite-like reaction, and showed marked improvement. Dermatologist should be aware of insect bite-like reaction associated with CLL as a distinct disease entity that is similar to insect bite or bullous pemphigoid.",
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Insect bite-like reaction with bullous lesions mimicking bullous pemphigoid in a patient with chronic lymphocytic leukemia. / Kim, Jee Eun; Kim, Soo Chan.

In: Annals of Dermatology, Vol. 30, No. 4, 08.2018, p. 468-472.

Research output: Contribution to journalArticle

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