The insular cortex is a limbic integration region that is engaged in emotional and cognitive functions. To investigate possible insular cortex abnormalities in schizophrenia, we measured insular gray matter volume and cortical surface size in drug-naive first-episode patients. Magnetic resonance images were used to explore the morphology of the insular cortex of 25 healthy male volunteers, and 25 male schizophrenic patients. Groups were matched for age, sex, height, and parental socio-economic status. Clinical dimension scores were correlated with insular gray matter volume and cortical surface area. Patients had a significant reduction in cortical surface area [patients = 2020 (206); controls = 2142 (204); F = 5.83, df = 1,47; P = 0.01] and gray matter volume [patients = 8.12 (0.77); controls = 8.57 (0.94); F = 3.93, df = 1,47; P = 0.05] in the left insular cortex. Insular gray matter volume and cortical surface size correlated negatively and significantly with the psychotic symptom dimension. Schizophrenic patients show morphological abnormalities in the insular cortex at early stages of the illness. These abnormalities are related to the severity of psychotic symptoms. Further investigations are needed to evaluate the role of the insula in the pathophysiology of schizophrenia. (C) 2000 Elsevier Science B.V.
Bibliographical noteFunding Information:
The present study was performed at the University of Iowa, Iowa City, IA, USA with support from the following grants: MH31593, MH40856, MH19113 and MHCRC43271
All Science Journal Classification (ASJC) codes
- Psychiatry and Mental health
- Biological Psychiatry