Insulin resistance and inflammatory signaling pathways modulated by high-fat diet

Taesun Park, Seung Jin Kim

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)


Obesity and associated disorders, of which incidences have increased dramatically worldwide in the last decades, give a serious threat to the current and future health of mankind on Earth. The World Health Organization (WHO) estimates that more than 1 billion adults worldwide are overweight and 300 million are clinically obese, based on the body mass index (BMI) equal to or over 30 kg/m2 [1]. Remarkably frightening is the similarly marked increase in obesity among children not only in Western countries, but also in the developing countries of the world [2,3]. Obesity is associated with many additional health problems, including increased risk of insulin resistance, type 2 diabetes, nonalcoholic fatty liver, atherosclerosis, degenerative disorders such as dementia, some immune-mediated disorders like asthma, and certain cancers [4,5]. This cluster of obesity-related pathologies has also started to emerge in children at young ages, a manifestation that was implausible only a few decades ago.

Original languageEnglish
Title of host publicationDietary Modulation of Cell Signaling Pathways
PublisherCRC Press
Number of pages32
ISBN (Electronic)9780849381492
ISBN (Print)9780849381485
Publication statusPublished - 2008 Jan 1


All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Park, T., & Kim, S. J. (2008). Insulin resistance and inflammatory signaling pathways modulated by high-fat diet. In Dietary Modulation of Cell Signaling Pathways (pp. 385-416). CRC Press.