Intakes of vitamin A, C, and E, and -carotene are associated with risk of cervical cancer: A case-control study in Korea

Jeongseon Kim, Mi Kyung Kim, Jae Kwan Lee, Jae Hoon Kim, Sung Kyong Son, Eun Seop Song, Kwang Beom Lee, Jung Pil Lee, Jong Min Lee, Young Mi Yun

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34 Citations (Scopus)

Abstract

Cervical cancer is one of the most common gynecological malignancies in Korea, although the incidence has been declining in recent years. This study explored whether antioxidant vitamin intakes influenced the risk of cervical cancer. The association between antioxidant vitamin intakes and cervical cancer risk was calculated for 144 cervical cancer cases and 288 age-matched, hospital-based controls using unconditional logistic regression models. Cases reported statistically lower mean dietary intakes of vitamin A, β-carotene, and vitamin C than did controls. Total intakes of vitamins A and E, which included both dietary and supplement intake, were also lower in cases. Those patients in the highest quartiles of dietary vitamin A, β-carotene, and vitamin C intakes had statistically significantly lower cervical cancer risks than those in the lowest quartiles for vitamin A, β-carotene, and vitamin C: odds ratio (OR) = 0.36 [95% confidence interval (CI) = 0.19-0.69), OR = 0.48 (CI = 0.26-0.88), and OR = 0.36 (CI = 0.18-0.69), respectively. Total intakes of vitamins A, C, and E were strongly inversely associated with cervical cancer risk: OR = 0.35 (CI = 0.19-0.65), OR = 0.35 (CI = 0.19-0.66), and OR = 0.53 (CI = 0.28-0.99), respectively. The findings support a role for increased antioxidant vitamin intake in decreasing the risk of cervical cancer. These associations need to be assessed in large prospective studies with long-term follow-up.

Original languageEnglish
Pages (from-to)181-189
Number of pages9
JournalNutrition and Cancer
Volume62
Issue number2
DOIs
Publication statusPublished - 2010 Feb 1

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Oncology
  • Nutrition and Dietetics
  • Cancer Research

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    Kim, J., Kim, M. K., Lee, J. K., Kim, J. H., Son, S. K., Song, E. S., Lee, K. B., Lee, J. P., Lee, J. M., & Yun, Y. M. (2010). Intakes of vitamin A, C, and E, and -carotene are associated with risk of cervical cancer: A case-control study in Korea. Nutrition and Cancer, 62(2), 181-189. https://doi.org/10.1080/01635580903305326