Integrase Strand Transfer Inhibitor Resistance Mutations in Antiretroviral Therapy-Naive and Treatment-Experienced HIV Patients in South Korea

Wooyong Jeong, In Young Jung, Heun Choi, Jung Ho Kim, Hye Seong, Jin Young Ahn, Su Jin Jeong, Nam Su Ku, June Myung Kim, JunYong Choi

Research output: Contribution to journalReview article

Abstract

Updated guidelines for the treatment of antiretroviral therapy (ART)-negative patients with HIV recommend integrase strand transfer inhibitor (INSTI)-based regimens. HIV patients are tested for resistance to antiretrovirals, and the reported prevalence of transmitted INSTI resistance remains rare worldwide. However, no data related to INSTI resistance in Korean HIV patients have been reported. We aimed to determine the prevalence of INSTI resistance-related mutations in South Korea. We subjected both ART-naive (n = 58) and ART-experienced Korean HIV patients (n = 41) to genotypic resistance analysis and determined a prevalence of INSTI major resistance mutations of 3.4% (n = 2) among ART-naive patients and 22.0% (n = 9) among ART-experienced patients. In the former group, both major INSTI resistance cases involved the nonpolymorphic E92Q mutation in the integrase strand. Our findings suggest that INSTI resistance testing should be included in the standard resistance screening protocols for Korean HIV patients.

Original languageEnglish
Pages (from-to)213-216
Number of pages4
JournalAIDS Research and Human Retroviruses
Volume35
Issue number2
DOIs
Publication statusPublished - 2019 Feb 1

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Integrases
Republic of Korea
HIV
Mutation
Therapeutics
HIV Integrase
Guidelines

All Science Journal Classification (ASJC) codes

  • Immunology
  • Virology
  • Infectious Diseases

Cite this

Jeong, Wooyong ; Jung, In Young ; Choi, Heun ; Kim, Jung Ho ; Seong, Hye ; Ahn, Jin Young ; Jeong, Su Jin ; Ku, Nam Su ; Kim, June Myung ; Choi, JunYong. / Integrase Strand Transfer Inhibitor Resistance Mutations in Antiretroviral Therapy-Naive and Treatment-Experienced HIV Patients in South Korea. In: AIDS Research and Human Retroviruses. 2019 ; Vol. 35, No. 2. pp. 213-216.
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abstract = "Updated guidelines for the treatment of antiretroviral therapy (ART)-negative patients with HIV recommend integrase strand transfer inhibitor (INSTI)-based regimens. HIV patients are tested for resistance to antiretrovirals, and the reported prevalence of transmitted INSTI resistance remains rare worldwide. However, no data related to INSTI resistance in Korean HIV patients have been reported. We aimed to determine the prevalence of INSTI resistance-related mutations in South Korea. We subjected both ART-naive (n = 58) and ART-experienced Korean HIV patients (n = 41) to genotypic resistance analysis and determined a prevalence of INSTI major resistance mutations of 3.4{\%} (n = 2) among ART-naive patients and 22.0{\%} (n = 9) among ART-experienced patients. In the former group, both major INSTI resistance cases involved the nonpolymorphic E92Q mutation in the integrase strand. Our findings suggest that INSTI resistance testing should be included in the standard resistance screening protocols for Korean HIV patients.",
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Integrase Strand Transfer Inhibitor Resistance Mutations in Antiretroviral Therapy-Naive and Treatment-Experienced HIV Patients in South Korea. / Jeong, Wooyong; Jung, In Young; Choi, Heun; Kim, Jung Ho; Seong, Hye; Ahn, Jin Young; Jeong, Su Jin; Ku, Nam Su; Kim, June Myung; Choi, JunYong.

In: AIDS Research and Human Retroviruses, Vol. 35, No. 2, 01.02.2019, p. 213-216.

Research output: Contribution to journalReview article

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T1 - Integrase Strand Transfer Inhibitor Resistance Mutations in Antiretroviral Therapy-Naive and Treatment-Experienced HIV Patients in South Korea

AU - Jeong, Wooyong

AU - Jung, In Young

AU - Choi, Heun

AU - Kim, Jung Ho

AU - Seong, Hye

AU - Ahn, Jin Young

AU - Jeong, Su Jin

AU - Ku, Nam Su

AU - Kim, June Myung

AU - Choi, JunYong

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N2 - Updated guidelines for the treatment of antiretroviral therapy (ART)-negative patients with HIV recommend integrase strand transfer inhibitor (INSTI)-based regimens. HIV patients are tested for resistance to antiretrovirals, and the reported prevalence of transmitted INSTI resistance remains rare worldwide. However, no data related to INSTI resistance in Korean HIV patients have been reported. We aimed to determine the prevalence of INSTI resistance-related mutations in South Korea. We subjected both ART-naive (n = 58) and ART-experienced Korean HIV patients (n = 41) to genotypic resistance analysis and determined a prevalence of INSTI major resistance mutations of 3.4% (n = 2) among ART-naive patients and 22.0% (n = 9) among ART-experienced patients. In the former group, both major INSTI resistance cases involved the nonpolymorphic E92Q mutation in the integrase strand. Our findings suggest that INSTI resistance testing should be included in the standard resistance screening protocols for Korean HIV patients.

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