Integrated microHall magnetometer to measure the magnetic properties of nanoparticles

Changwook Min, Jongmin Park, Jae Kyoung Mun, Yongjun Lim, Jouha Min, Jong Won Lim, Dong Min Kang, Ho Kyun Ahn, Tae Hyun Shin, Jinwoo Cheon, Hae Seung Lee, Ralph Weissleder, Cesar M. Castro, Hakho Lee

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Magnetic nanoparticles (MNPs) are widely used in biomedical and clinical applications, including medical imaging, therapeutics, and biological sample processing. Rapid characterization of MNPs, notably their magnetic moments, should facilitate optimization of particle synthesis and accelerate assay development. Here, we report a compact and low-cost magnetometer for fast, on-site MNP characterization. Termed integrated microHall magnetometer (iHM), our device was fabricated using standard semiconductor processes: an array of Hall sensors, transistor switches, and amplifiers were integrated into a single chip, thus improving the detection sensitivity and facilitating chip operation. By applying the iHM, we demonstrate versatile magnetic assays. We measured the magnetic susceptibility and moments of MNPs using small sample amounts (∼10 pL), identified different MNP compositions in mixtures, and detected MNP-labeled single cells.

Original languageEnglish
Pages (from-to)4000-4007
Number of pages8
JournalLab on a Chip
Volume17
Issue number23
DOIs
Publication statusPublished - 2017 Jan 1

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Magnetometers
Nanoparticles
Magnetic properties
Magnetic moments
Assays
Semiconductors
Medical imaging
Diagnostic Imaging
Magnetic susceptibility
Transistors
Switches
Semiconductor materials
Costs and Cost Analysis
Equipment and Supplies
Sensors
Processing
Chemical analysis
Costs

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Biomedical Engineering

Cite this

Min, C., Park, J., Mun, J. K., Lim, Y., Min, J., Lim, J. W., ... Lee, H. (2017). Integrated microHall magnetometer to measure the magnetic properties of nanoparticles. Lab on a Chip, 17(23), 4000-4007. https://doi.org/10.1039/c7lc00934h
Min, Changwook ; Park, Jongmin ; Mun, Jae Kyoung ; Lim, Yongjun ; Min, Jouha ; Lim, Jong Won ; Kang, Dong Min ; Ahn, Ho Kyun ; Shin, Tae Hyun ; Cheon, Jinwoo ; Lee, Hae Seung ; Weissleder, Ralph ; Castro, Cesar M. ; Lee, Hakho. / Integrated microHall magnetometer to measure the magnetic properties of nanoparticles. In: Lab on a Chip. 2017 ; Vol. 17, No. 23. pp. 4000-4007.
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Min, C, Park, J, Mun, JK, Lim, Y, Min, J, Lim, JW, Kang, DM, Ahn, HK, Shin, TH, Cheon, J, Lee, HS, Weissleder, R, Castro, CM & Lee, H 2017, 'Integrated microHall magnetometer to measure the magnetic properties of nanoparticles', Lab on a Chip, vol. 17, no. 23, pp. 4000-4007. https://doi.org/10.1039/c7lc00934h

Integrated microHall magnetometer to measure the magnetic properties of nanoparticles. / Min, Changwook; Park, Jongmin; Mun, Jae Kyoung; Lim, Yongjun; Min, Jouha; Lim, Jong Won; Kang, Dong Min; Ahn, Ho Kyun; Shin, Tae Hyun; Cheon, Jinwoo; Lee, Hae Seung; Weissleder, Ralph; Castro, Cesar M.; Lee, Hakho.

In: Lab on a Chip, Vol. 17, No. 23, 01.01.2017, p. 4000-4007.

Research output: Contribution to journalArticle

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AU - Min, Changwook

AU - Park, Jongmin

AU - Mun, Jae Kyoung

AU - Lim, Yongjun

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AU - Lim, Jong Won

AU - Kang, Dong Min

AU - Ahn, Ho Kyun

AU - Shin, Tae Hyun

AU - Cheon, Jinwoo

AU - Lee, Hae Seung

AU - Weissleder, Ralph

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AU - Lee, Hakho

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