Integrated microHall magnetometer to measure the magnetic properties of nanoparticles

Changwook Min, Jongmin Park, Jae Kyoung Mun, Yongjun Lim, Jouha Min, Jong Won Lim, Dong Min Kang, Ho Kyun Ahn, Tae Hyun Shin, Jinwoo Cheon, Hae Seung Lee, Ralph Weissleder, Cesar M. Castro, Hakho Lee

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3 Citations (Scopus)

Abstract

Magnetic nanoparticles (MNPs) are widely used in biomedical and clinical applications, including medical imaging, therapeutics, and biological sample processing. Rapid characterization of MNPs, notably their magnetic moments, should facilitate optimization of particle synthesis and accelerate assay development. Here, we report a compact and low-cost magnetometer for fast, on-site MNP characterization. Termed integrated microHall magnetometer (iHM), our device was fabricated using standard semiconductor processes: an array of Hall sensors, transistor switches, and amplifiers were integrated into a single chip, thus improving the detection sensitivity and facilitating chip operation. By applying the iHM, we demonstrate versatile magnetic assays. We measured the magnetic susceptibility and moments of MNPs using small sample amounts (∼10 pL), identified different MNP compositions in mixtures, and detected MNP-labeled single cells.

Original languageEnglish
Pages (from-to)4000-4007
Number of pages8
JournalLab on a chip
Volume17
Issue number23
DOIs
Publication statusPublished - 2017 Dec 7

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Biomedical Engineering

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  • Cite this

    Min, C., Park, J., Mun, J. K., Lim, Y., Min, J., Lim, J. W., Kang, D. M., Ahn, H. K., Shin, T. H., Cheon, J., Lee, H. S., Weissleder, R., Castro, C. M., & Lee, H. (2017). Integrated microHall magnetometer to measure the magnetic properties of nanoparticles. Lab on a chip, 17(23), 4000-4007. https://doi.org/10.1039/c7lc00934h