Integrated psychosocial and opioid-antagonist treatment for alcohol dependence: A systematic review of controlled evaluations

Michael G. Vaughn, Matthew O. Howard

Research output: Contribution to journalArticle

17 Citations (Scopus)


Methodological characteristics and outcomes of 14 controlled clinical investigations of integrated psychosocial and opioid-antagonist alcohol dependence treatment were evaluated. The 14 studies were identified through computerized bibliographic and manual literature searches. Clients receiving integrated psychosocial and opioid-antagonist treatment had outcomes superior to those of clients receiving monotherapy (generally placebo and standard psychosocial treatment). Rates of relapse, levels of self-reported alcohol craving, and extent of posttreatment alcohol consumption were significantly reduced in clients receiving integrated therapy relative to controls. However, the long-term efficacy of integrated psychosocial and opioid-antagonist alcohol dependence treatment was not established, and client factors associated with the differential effectiveness of integrated interventions were not identified.

Original languageEnglish
Pages (from-to)41-55
Number of pages15
JournalSocial Work Research
Issue number1
Publication statusPublished - 2004 Mar 1


All Science Journal Classification (ASJC) codes

  • Sociology and Political Science

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