Intensive pharmacologic treatment in patients with acute non ST-segment elevation myocardial infarction who did not undergo percutaneous coronary intervention

Chang Jeong Hae, Keun Ahn Young, Ho Jeong Myung, Chull Chae Shung, Hyun Kim Jong, Whan Seong In, Jo Kim Young, Ho Hur Seung, Donghoon Choi, Jong Hong Taek, Han Yoon Jung, Young Rhew Jae, Keon Chae Jei, Il Kim Doo, Ho Chae In, Kwon Koo Bon, Ok Kim Byung, Hee Lee Nae, Yong Hwang Jin, Kyu Oh SeokChan Cho Myeong, Sik Kim Kee, Tae Jeong Kyoung, Yong Lee Myoung, Jin Kim Chong, Sung Chung Wook, Jea Tahk Seung, Ho Bae Jang, Woon Rha Seung, Soo Park Keum, Rok Han Kyoo, Hoon Ahn Tae, Hyun Kim Moo, Bae Seung Ki, Young Yang Ju, Yun Rhim Chong, Cheol Gwon Hyeon, Wook Park Seong, Youp Koh Young, Jae Joo Seung, Joong Kim Soo, Kyu Jin Dong, Man Cho Jin, Yangsoo Jang, Gwan Cho Jeong, Jung Park Seung

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: The aim of this study was to assess the impact of more aggressive pharmacological treatment on short-term clinical outcomes in patients with acute non ST-segment elevation myocardial infarction (NSTEMI) who do not undergo percutaneous coronary intervention (PCI). Methods and Results: The 924 NSTEMI patients treated with early conservative strategy (69.2±12.5 years, 637 males) in 50 hospitals that were high-volume centers with facilities for primary PCI were recruited to the Korean Acute Myocardial Infarction Registry (KAMIR) from November 2005 to August 2007. For all patients, the pharmacotherapy index based on the use of drugs during hospital stay was assessed (range of points 0-10). Primary endpoint was the combined in-hospital mortality and morbidity and major adverse cardiac events during 1 month of clinical follow-up. Of the patients, data from 847 who were followed-up for 1 month after discharge were analyzed. The rate of the primary endpoint decreased with an increase of the pharmacotherapy index and this result was similar in the low- and high-risk groups. In the multivariate analysis, low pharmacotherapy index (≤4 points) was an independent predictor of the primary endpoint. Conclusions: More intensive pharmacological treatment may improve short-term clinical outcomes in acute NSETMI patients who do not undergo PCI.

Original languageEnglish
Pages (from-to)1403-1409
Number of pages7
JournalCirculation Journal
Volume72
Issue number9
DOIs
Publication statusPublished - 2008 Sep 4

Fingerprint

Percutaneous Coronary Intervention
Drug Therapy
High-Volume Hospitals
Pharmacology
Therapeutics
Hospital Mortality
Registries
Length of Stay
Multivariate Analysis
Myocardial Infarction
ST Elevation Myocardial Infarction
Non-ST Elevated Myocardial Infarction
Morbidity
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Hae, Chang Jeong ; Young, Keun Ahn ; Myung, Ho Jeong ; Shung, Chull Chae ; Jong, Hyun Kim ; In, Whan Seong ; Young, Jo Kim ; Seung, Ho Hur ; Choi, Donghoon ; Taek, Jong Hong ; Jung, Han Yoon ; Jae, Young Rhew ; Jei, Keon Chae ; Doo, Il Kim ; In, Ho Chae ; Bon, Kwon Koo ; Byung, Ok Kim ; Nae, Hee Lee ; Jin, Yong Hwang ; Seok, Kyu Oh ; Myeong, Chan Cho ; Kee, Sik Kim ; Kyoung, Tae Jeong ; Myoung, Yong Lee ; Chong, Jin Kim ; Wook, Sung Chung ; Seung, Jea Tahk ; Jang, Ho Bae ; Seung, Woon Rha ; Keum, Soo Park ; Kyoo, Rok Han ; Tae, Hoon Ahn ; Moo, Hyun Kim ; Ki, Bae Seung ; Ju, Young Yang ; Chong, Yun Rhim ; Hyeon, Cheol Gwon ; Seong, Wook Park ; Young, Youp Koh ; Seung, Jae Joo ; Soo, Joong Kim ; Dong, Kyu Jin ; Jin, Man Cho ; Jang, Yangsoo ; Jeong, Gwan Cho ; Seung, Jung Park. / Intensive pharmacologic treatment in patients with acute non ST-segment elevation myocardial infarction who did not undergo percutaneous coronary intervention. In: Circulation Journal. 2008 ; Vol. 72, No. 9. pp. 1403-1409.
@article{91639bff81ef453eb022736206fcfdfa,
title = "Intensive pharmacologic treatment in patients with acute non ST-segment elevation myocardial infarction who did not undergo percutaneous coronary intervention",
abstract = "Background: The aim of this study was to assess the impact of more aggressive pharmacological treatment on short-term clinical outcomes in patients with acute non ST-segment elevation myocardial infarction (NSTEMI) who do not undergo percutaneous coronary intervention (PCI). Methods and Results: The 924 NSTEMI patients treated with early conservative strategy (69.2±12.5 years, 637 males) in 50 hospitals that were high-volume centers with facilities for primary PCI were recruited to the Korean Acute Myocardial Infarction Registry (KAMIR) from November 2005 to August 2007. For all patients, the pharmacotherapy index based on the use of drugs during hospital stay was assessed (range of points 0-10). Primary endpoint was the combined in-hospital mortality and morbidity and major adverse cardiac events during 1 month of clinical follow-up. Of the patients, data from 847 who were followed-up for 1 month after discharge were analyzed. The rate of the primary endpoint decreased with an increase of the pharmacotherapy index and this result was similar in the low- and high-risk groups. In the multivariate analysis, low pharmacotherapy index (≤4 points) was an independent predictor of the primary endpoint. Conclusions: More intensive pharmacological treatment may improve short-term clinical outcomes in acute NSETMI patients who do not undergo PCI.",
author = "Hae, {Chang Jeong} and Young, {Keun Ahn} and Myung, {Ho Jeong} and Shung, {Chull Chae} and Jong, {Hyun Kim} and In, {Whan Seong} and Young, {Jo Kim} and Seung, {Ho Hur} and Donghoon Choi and Taek, {Jong Hong} and Jung, {Han Yoon} and Jae, {Young Rhew} and Jei, {Keon Chae} and Doo, {Il Kim} and In, {Ho Chae} and Bon, {Kwon Koo} and Byung, {Ok Kim} and Nae, {Hee Lee} and Jin, {Yong Hwang} and Seok, {Kyu Oh} and Myeong, {Chan Cho} and Kee, {Sik Kim} and Kyoung, {Tae Jeong} and Myoung, {Yong Lee} and Chong, {Jin Kim} and Wook, {Sung Chung} and Seung, {Jea Tahk} and Jang, {Ho Bae} and Seung, {Woon Rha} and Keum, {Soo Park} and Kyoo, {Rok Han} and Tae, {Hoon Ahn} and Moo, {Hyun Kim} and Ki, {Bae Seung} and Ju, {Young Yang} and Chong, {Yun Rhim} and Hyeon, {Cheol Gwon} and Seong, {Wook Park} and Young, {Youp Koh} and Seung, {Jae Joo} and Soo, {Joong Kim} and Dong, {Kyu Jin} and Jin, {Man Cho} and Yangsoo Jang and Jeong, {Gwan Cho} and Seung, {Jung Park}",
year = "2008",
month = "9",
day = "4",
doi = "10.1253/circj.CJ-08-0048",
language = "English",
volume = "72",
pages = "1403--1409",
journal = "Circulation Journal",
issn = "1346-9843",
publisher = "Japanese Circulation Society",
number = "9",

}

Hae, CJ, Young, KA, Myung, HJ, Shung, CC, Jong, HK, In, WS, Young, JK, Seung, HH, Choi, D, Taek, JH, Jung, HY, Jae, YR, Jei, KC, Doo, IK, In, HC, Bon, KK, Byung, OK, Nae, HL, Jin, YH, Seok, KO, Myeong, CC, Kee, SK, Kyoung, TJ, Myoung, YL, Chong, JK, Wook, SC, Seung, JT, Jang, HB, Seung, WR, Keum, SP, Kyoo, RH, Tae, HA, Moo, HK, Ki, BS, Ju, YY, Chong, YR, Hyeon, CG, Seong, WP, Young, YK, Seung, JJ, Soo, JK, Dong, KJ, Jin, MC, Jang, Y, Jeong, GC & Seung, JP 2008, 'Intensive pharmacologic treatment in patients with acute non ST-segment elevation myocardial infarction who did not undergo percutaneous coronary intervention', Circulation Journal, vol. 72, no. 9, pp. 1403-1409. https://doi.org/10.1253/circj.CJ-08-0048

Intensive pharmacologic treatment in patients with acute non ST-segment elevation myocardial infarction who did not undergo percutaneous coronary intervention. / Hae, Chang Jeong; Young, Keun Ahn; Myung, Ho Jeong; Shung, Chull Chae; Jong, Hyun Kim; In, Whan Seong; Young, Jo Kim; Seung, Ho Hur; Choi, Donghoon; Taek, Jong Hong; Jung, Han Yoon; Jae, Young Rhew; Jei, Keon Chae; Doo, Il Kim; In, Ho Chae; Bon, Kwon Koo; Byung, Ok Kim; Nae, Hee Lee; Jin, Yong Hwang; Seok, Kyu Oh; Myeong, Chan Cho; Kee, Sik Kim; Kyoung, Tae Jeong; Myoung, Yong Lee; Chong, Jin Kim; Wook, Sung Chung; Seung, Jea Tahk; Jang, Ho Bae; Seung, Woon Rha; Keum, Soo Park; Kyoo, Rok Han; Tae, Hoon Ahn; Moo, Hyun Kim; Ki, Bae Seung; Ju, Young Yang; Chong, Yun Rhim; Hyeon, Cheol Gwon; Seong, Wook Park; Young, Youp Koh; Seung, Jae Joo; Soo, Joong Kim; Dong, Kyu Jin; Jin, Man Cho; Jang, Yangsoo; Jeong, Gwan Cho; Seung, Jung Park.

In: Circulation Journal, Vol. 72, No. 9, 04.09.2008, p. 1403-1409.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Intensive pharmacologic treatment in patients with acute non ST-segment elevation myocardial infarction who did not undergo percutaneous coronary intervention

AU - Hae, Chang Jeong

AU - Young, Keun Ahn

AU - Myung, Ho Jeong

AU - Shung, Chull Chae

AU - Jong, Hyun Kim

AU - In, Whan Seong

AU - Young, Jo Kim

AU - Seung, Ho Hur

AU - Choi, Donghoon

AU - Taek, Jong Hong

AU - Jung, Han Yoon

AU - Jae, Young Rhew

AU - Jei, Keon Chae

AU - Doo, Il Kim

AU - In, Ho Chae

AU - Bon, Kwon Koo

AU - Byung, Ok Kim

AU - Nae, Hee Lee

AU - Jin, Yong Hwang

AU - Seok, Kyu Oh

AU - Myeong, Chan Cho

AU - Kee, Sik Kim

AU - Kyoung, Tae Jeong

AU - Myoung, Yong Lee

AU - Chong, Jin Kim

AU - Wook, Sung Chung

AU - Seung, Jea Tahk

AU - Jang, Ho Bae

AU - Seung, Woon Rha

AU - Keum, Soo Park

AU - Kyoo, Rok Han

AU - Tae, Hoon Ahn

AU - Moo, Hyun Kim

AU - Ki, Bae Seung

AU - Ju, Young Yang

AU - Chong, Yun Rhim

AU - Hyeon, Cheol Gwon

AU - Seong, Wook Park

AU - Young, Youp Koh

AU - Seung, Jae Joo

AU - Soo, Joong Kim

AU - Dong, Kyu Jin

AU - Jin, Man Cho

AU - Jang, Yangsoo

AU - Jeong, Gwan Cho

AU - Seung, Jung Park

PY - 2008/9/4

Y1 - 2008/9/4

N2 - Background: The aim of this study was to assess the impact of more aggressive pharmacological treatment on short-term clinical outcomes in patients with acute non ST-segment elevation myocardial infarction (NSTEMI) who do not undergo percutaneous coronary intervention (PCI). Methods and Results: The 924 NSTEMI patients treated with early conservative strategy (69.2±12.5 years, 637 males) in 50 hospitals that were high-volume centers with facilities for primary PCI were recruited to the Korean Acute Myocardial Infarction Registry (KAMIR) from November 2005 to August 2007. For all patients, the pharmacotherapy index based on the use of drugs during hospital stay was assessed (range of points 0-10). Primary endpoint was the combined in-hospital mortality and morbidity and major adverse cardiac events during 1 month of clinical follow-up. Of the patients, data from 847 who were followed-up for 1 month after discharge were analyzed. The rate of the primary endpoint decreased with an increase of the pharmacotherapy index and this result was similar in the low- and high-risk groups. In the multivariate analysis, low pharmacotherapy index (≤4 points) was an independent predictor of the primary endpoint. Conclusions: More intensive pharmacological treatment may improve short-term clinical outcomes in acute NSETMI patients who do not undergo PCI.

AB - Background: The aim of this study was to assess the impact of more aggressive pharmacological treatment on short-term clinical outcomes in patients with acute non ST-segment elevation myocardial infarction (NSTEMI) who do not undergo percutaneous coronary intervention (PCI). Methods and Results: The 924 NSTEMI patients treated with early conservative strategy (69.2±12.5 years, 637 males) in 50 hospitals that were high-volume centers with facilities for primary PCI were recruited to the Korean Acute Myocardial Infarction Registry (KAMIR) from November 2005 to August 2007. For all patients, the pharmacotherapy index based on the use of drugs during hospital stay was assessed (range of points 0-10). Primary endpoint was the combined in-hospital mortality and morbidity and major adverse cardiac events during 1 month of clinical follow-up. Of the patients, data from 847 who were followed-up for 1 month after discharge were analyzed. The rate of the primary endpoint decreased with an increase of the pharmacotherapy index and this result was similar in the low- and high-risk groups. In the multivariate analysis, low pharmacotherapy index (≤4 points) was an independent predictor of the primary endpoint. Conclusions: More intensive pharmacological treatment may improve short-term clinical outcomes in acute NSETMI patients who do not undergo PCI.

UR - http://www.scopus.com/inward/record.url?scp=50549100902&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=50549100902&partnerID=8YFLogxK

U2 - 10.1253/circj.CJ-08-0048

DO - 10.1253/circj.CJ-08-0048

M3 - Article

C2 - 18724013

AN - SCOPUS:50549100902

VL - 72

SP - 1403

EP - 1409

JO - Circulation Journal

JF - Circulation Journal

SN - 1346-9843

IS - 9

ER -