Intensive pharmacologic treatment in patients with acute non ST-segment elevation myocardial infarction who did not undergo percutaneous coronary intervention

Chang Jeong Hae, Keun Ahn Young, Ho Jeong Myung, Chull Chae Shung, Hyun Kim Jong, Whan Seong In, Jo Kim Young, Ho Hur Seung, Hoon Choi Dong, Jong Hong Taek, Han Yoon Jung, Young Rhew Jae, Keon Chae Jei, Il Kim Doo, Ho Chae In, Kwon Koo Bon, Ok Kim Byung, Hee Lee Nae, Yong Hwang Jin, Kyu Oh SeokChan Cho Myeong, Sik Kim Kee, Tae Jeong Kyoung, Yong Lee Myoung, Jin Kim Chong, Sung Chung Wook, Jea Tahk Seung, Ho Bae Jang, Woon Rha Seung, Soo Park Keum, Rok Han Kyoo, Hoon Ahn Tae, Hyun Kim Moo, Bae Seung Ki, Young Yang Ju, Yun Rhim Chong, Cheol Gwon Hyeon, Wook Park Seong, Youp Koh Young, Jae Joo Seung, Joong Kim Soo, Kyu Jin Dong, Man Cho Jin, Soo Jang Yang, Gwan Cho Jeong, Jung Park Seung

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Abstract

Background: The aim of this study was to assess the impact of more aggressive pharmacological treatment on short-term clinical outcomes in patients with acute non ST-segment elevation myocardial infarction (NSTEMI) who do not undergo percutaneous coronary intervention (PCI). Methods and Results: The 924 NSTEMI patients treated with early conservative strategy (69.2±12.5 years, 637 males) in 50 hospitals that were high-volume centers with facilities for primary PCI were recruited to the Korean Acute Myocardial Infarction Registry (KAMIR) from November 2005 to August 2007. For all patients, the pharmacotherapy index based on the use of drugs during hospital stay was assessed (range of points 0-10). Primary endpoint was the combined in-hospital mortality and morbidity and major adverse cardiac events during 1 month of clinical follow-up. Of the patients, data from 847 who were followed-up for 1 month after discharge were analyzed. The rate of the primary endpoint decreased with an increase of the pharmacotherapy index and this result was similar in the low- and high-risk groups. In the multivariate analysis, low pharmacotherapy index (≤4 points) was an independent predictor of the primary endpoint. Conclusions: More intensive pharmacological treatment may improve short-term clinical outcomes in acute NSETMI patients who do not undergo PCI.

Original languageEnglish
Pages (from-to)1403-1409
Number of pages7
JournalCirculation Journal
Volume72
Issue number9
DOIs
Publication statusPublished - 2008 Sep 4

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All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Hae, C. J., Young, K. A., Myung, H. J., Shung, C. C., Jong, H. K., In, W. S., Young, J. K., Seung, H. H., Dong, H. C., Taek, J. H., Jung, H. Y., Jae, Y. R., Jei, K. C., Doo, I. K., In, H. C., Bon, K. K., Byung, O. K., Nae, H. L., Jin, Y. H., ... Seung, J. P. (2008). Intensive pharmacologic treatment in patients with acute non ST-segment elevation myocardial infarction who did not undergo percutaneous coronary intervention. Circulation Journal, 72(9), 1403-1409. https://doi.org/10.1253/circj.CJ-08-0048