Inter-observer variability of response evaluation criteria for hepatocellular carcinoma treated with chemoembolization

Beom Kyung Kim, Kyung Ah Kim, Myeong Jin Kim, Junyong Park, doyoung kim, SangHoon Ahn, KwangHyub Han, Seungup Kim, Mi Suk Park

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2 Citations (Scopus)

Abstract

Background: Data comparing EASL and mRECIST criteria for response evaluation in treatment of hepatocellular carcinoma are rare. We evaluated inter-observer variability by these two response evaluation criteria in treatment-naïve patients undergoing chemoembolization. Methods: For 133 patients undergoing chemoembolization, two radiologists independently measured sum of bi-dimensional and uni-dimensional diameters at baseline using both EASL criteria and mRECIST, and their changes on first follow-up for up to 5 target lesions. Results: Concordance correlation coefficients for sum of bi-dimensional and uni-dimensional diameters at baseline between two observers were 0.992 and 0.988, respectively. However, those for their changes on follow-up were 0.865 and 0.877, respectively. Similarly, mean differences in sum of bi-dimensional and uni-dimensional diameters at baseline between two observers were small; -0.455 and 0.079. cm, respectively. However, mean differences in changes (%) in sum of bi-dimensional and uni-dimensional diameters on first follow-up between observers increased by -9.715% and -9.320%, respectively. Regarding tumour numbers, kappa-value between observers was 0.942. For treatment response (complete or partial response, stable disease and progression), kappa-value was 0.941 by both criteria. When only up to two target lesions were assessed, kappa-value was 1.000 by both criteria. Conclusions: Inter-observer agreements using both response evaluation criteria were excellent, especially when up to two targets were assessed.

Original languageEnglish
Pages (from-to)682-688
Number of pages7
JournalDigestive and Liver Disease
Volume47
Issue number8
DOIs
Publication statusPublished - 2015 Aug 1

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Observer Variation
Hepatocellular Carcinoma
Disease Progression
Therapeutics
Neoplasms

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

@article{eb39de37825646d3b3b056146e1fd7aa,
title = "Inter-observer variability of response evaluation criteria for hepatocellular carcinoma treated with chemoembolization",
abstract = "Background: Data comparing EASL and mRECIST criteria for response evaluation in treatment of hepatocellular carcinoma are rare. We evaluated inter-observer variability by these two response evaluation criteria in treatment-na{\"i}ve patients undergoing chemoembolization. Methods: For 133 patients undergoing chemoembolization, two radiologists independently measured sum of bi-dimensional and uni-dimensional diameters at baseline using both EASL criteria and mRECIST, and their changes on first follow-up for up to 5 target lesions. Results: Concordance correlation coefficients for sum of bi-dimensional and uni-dimensional diameters at baseline between two observers were 0.992 and 0.988, respectively. However, those for their changes on follow-up were 0.865 and 0.877, respectively. Similarly, mean differences in sum of bi-dimensional and uni-dimensional diameters at baseline between two observers were small; -0.455 and 0.079. cm, respectively. However, mean differences in changes ({\%}) in sum of bi-dimensional and uni-dimensional diameters on first follow-up between observers increased by -9.715{\%} and -9.320{\%}, respectively. Regarding tumour numbers, kappa-value between observers was 0.942. For treatment response (complete or partial response, stable disease and progression), kappa-value was 0.941 by both criteria. When only up to two target lesions were assessed, kappa-value was 1.000 by both criteria. Conclusions: Inter-observer agreements using both response evaluation criteria were excellent, especially when up to two targets were assessed.",
author = "Kim, {Beom Kyung} and Kim, {Kyung Ah} and Kim, {Myeong Jin} and Junyong Park and doyoung kim and SangHoon Ahn and KwangHyub Han and Seungup Kim and Park, {Mi Suk}",
year = "2015",
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doi = "10.1016/j.dld.2015.04.004",
language = "English",
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Inter-observer variability of response evaluation criteria for hepatocellular carcinoma treated with chemoembolization. / Kim, Beom Kyung; Kim, Kyung Ah; Kim, Myeong Jin; Park, Junyong; kim, doyoung; Ahn, SangHoon; Han, KwangHyub; Kim, Seungup; Park, Mi Suk.

In: Digestive and Liver Disease, Vol. 47, No. 8, 01.08.2015, p. 682-688.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Inter-observer variability of response evaluation criteria for hepatocellular carcinoma treated with chemoembolization

AU - Kim, Beom Kyung

AU - Kim, Kyung Ah

AU - Kim, Myeong Jin

AU - Park, Junyong

AU - kim, doyoung

AU - Ahn, SangHoon

AU - Han, KwangHyub

AU - Kim, Seungup

AU - Park, Mi Suk

PY - 2015/8/1

Y1 - 2015/8/1

N2 - Background: Data comparing EASL and mRECIST criteria for response evaluation in treatment of hepatocellular carcinoma are rare. We evaluated inter-observer variability by these two response evaluation criteria in treatment-naïve patients undergoing chemoembolization. Methods: For 133 patients undergoing chemoembolization, two radiologists independently measured sum of bi-dimensional and uni-dimensional diameters at baseline using both EASL criteria and mRECIST, and their changes on first follow-up for up to 5 target lesions. Results: Concordance correlation coefficients for sum of bi-dimensional and uni-dimensional diameters at baseline between two observers were 0.992 and 0.988, respectively. However, those for their changes on follow-up were 0.865 and 0.877, respectively. Similarly, mean differences in sum of bi-dimensional and uni-dimensional diameters at baseline between two observers were small; -0.455 and 0.079. cm, respectively. However, mean differences in changes (%) in sum of bi-dimensional and uni-dimensional diameters on first follow-up between observers increased by -9.715% and -9.320%, respectively. Regarding tumour numbers, kappa-value between observers was 0.942. For treatment response (complete or partial response, stable disease and progression), kappa-value was 0.941 by both criteria. When only up to two target lesions were assessed, kappa-value was 1.000 by both criteria. Conclusions: Inter-observer agreements using both response evaluation criteria were excellent, especially when up to two targets were assessed.

AB - Background: Data comparing EASL and mRECIST criteria for response evaluation in treatment of hepatocellular carcinoma are rare. We evaluated inter-observer variability by these two response evaluation criteria in treatment-naïve patients undergoing chemoembolization. Methods: For 133 patients undergoing chemoembolization, two radiologists independently measured sum of bi-dimensional and uni-dimensional diameters at baseline using both EASL criteria and mRECIST, and their changes on first follow-up for up to 5 target lesions. Results: Concordance correlation coefficients for sum of bi-dimensional and uni-dimensional diameters at baseline between two observers were 0.992 and 0.988, respectively. However, those for their changes on follow-up were 0.865 and 0.877, respectively. Similarly, mean differences in sum of bi-dimensional and uni-dimensional diameters at baseline between two observers were small; -0.455 and 0.079. cm, respectively. However, mean differences in changes (%) in sum of bi-dimensional and uni-dimensional diameters on first follow-up between observers increased by -9.715% and -9.320%, respectively. Regarding tumour numbers, kappa-value between observers was 0.942. For treatment response (complete or partial response, stable disease and progression), kappa-value was 0.941 by both criteria. When only up to two target lesions were assessed, kappa-value was 1.000 by both criteria. Conclusions: Inter-observer agreements using both response evaluation criteria were excellent, especially when up to two targets were assessed.

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U2 - 10.1016/j.dld.2015.04.004

DO - 10.1016/j.dld.2015.04.004

M3 - Article

C2 - 25977216

AN - SCOPUS:84937524598

VL - 47

SP - 682

EP - 688

JO - Digestive and Liver Disease

JF - Digestive and Liver Disease

SN - 1590-8658

IS - 8

ER -