Interaction between GNB3 C825T and ACE I/D polymorphisms in essential hypertension in Koreans

Y. Bae, C. Park, J. Han, Y. J. Hong, H. H. Song, E. S. Shin, J. E. Lee, B. G. Han, Y. Jang, D. J. Shin, S. K. Yoon

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Abstract

Essential hypertension (EH) is considered a typical polygenic disease, so the evaluation of gene-gene interactions rather than the determination of single gene effects is crucial to understanding any genetic influences. The G-protein β3-subunit (GNB3) 825T allele, associated with enhanced G-protein signalling, is a strong candidate for interactions with polymorphisms, such as insertion/deletion (I/D) polymorphism of angiotensin I-converting enzyme (ACE) gene. We investigated whether there is an association between GNB3 C825T and ACE I/D polymorphisms for the development of EH. We carried out a case-control study of 688 hypertensive and 924 normotensive subjects recruited from South Korea. The GNB3 C825T and ACE I/D genotypes were determined by polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism methods, respectively. The distributions of alleles and genotypes for the GNB3 C825T and ACE I/D polymorphisms were not found to be significantly associated with hypertensive status in either males or females. Logistic regression analysis indicated that the GNB3 825T allele carriers were positively associated with EH in males (odds ratio (OR) for TT/CT, 1.459; 95% confidence interval (CI), 1.048-2.033, P=0.0255). In analysis of gene-gene interaction, we found that there was a significant interaction between the GNB3 825T and ACE D alleles (P<0.05). OR for EH was significantly higher in 825T allele carriers with ACE D allele (OR, 1.490; 95% CI, 1.117-1.987, P=0.0067). A significant interaction between the GNB3 825T and the ACE D alleles may contribute to the predisposing effect for the development of EH in Koreans.

Original languageEnglish
Pages (from-to)159-166
Number of pages8
JournalJournal of Human Hypertension
Volume21
Issue number2
DOIs
Publication statusPublished - 2007 Feb 1

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Peptidyl-Dipeptidase A
Alleles
Genes
Odds Ratio
GTP-Binding Proteins
Genotype
Confidence Intervals
Polymerase Chain Reaction
Republic of Korea
Protein Subunits
Essential Hypertension
Restriction Fragment Length Polymorphisms
Case-Control Studies
Logistic Models
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Bae, Y., Park, C., Han, J., Hong, Y. J., Song, H. H., Shin, E. S., ... Yoon, S. K. (2007). Interaction between GNB3 C825T and ACE I/D polymorphisms in essential hypertension in Koreans. Journal of Human Hypertension, 21(2), 159-166. https://doi.org/10.1038/sj.jhh.1002110
Bae, Y. ; Park, C. ; Han, J. ; Hong, Y. J. ; Song, H. H. ; Shin, E. S. ; Lee, J. E. ; Han, B. G. ; Jang, Y. ; Shin, D. J. ; Yoon, S. K. / Interaction between GNB3 C825T and ACE I/D polymorphisms in essential hypertension in Koreans. In: Journal of Human Hypertension. 2007 ; Vol. 21, No. 2. pp. 159-166.
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abstract = "Essential hypertension (EH) is considered a typical polygenic disease, so the evaluation of gene-gene interactions rather than the determination of single gene effects is crucial to understanding any genetic influences. The G-protein β3-subunit (GNB3) 825T allele, associated with enhanced G-protein signalling, is a strong candidate for interactions with polymorphisms, such as insertion/deletion (I/D) polymorphism of angiotensin I-converting enzyme (ACE) gene. We investigated whether there is an association between GNB3 C825T and ACE I/D polymorphisms for the development of EH. We carried out a case-control study of 688 hypertensive and 924 normotensive subjects recruited from South Korea. The GNB3 C825T and ACE I/D genotypes were determined by polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism methods, respectively. The distributions of alleles and genotypes for the GNB3 C825T and ACE I/D polymorphisms were not found to be significantly associated with hypertensive status in either males or females. Logistic regression analysis indicated that the GNB3 825T allele carriers were positively associated with EH in males (odds ratio (OR) for TT/CT, 1.459; 95{\%} confidence interval (CI), 1.048-2.033, P=0.0255). In analysis of gene-gene interaction, we found that there was a significant interaction between the GNB3 825T and ACE D alleles (P<0.05). OR for EH was significantly higher in 825T allele carriers with ACE D allele (OR, 1.490; 95{\%} CI, 1.117-1.987, P=0.0067). A significant interaction between the GNB3 825T and the ACE D alleles may contribute to the predisposing effect for the development of EH in Koreans.",
author = "Y. Bae and C. Park and J. Han and Hong, {Y. J.} and Song, {H. H.} and Shin, {E. S.} and Lee, {J. E.} and Han, {B. G.} and Y. Jang and Shin, {D. J.} and Yoon, {S. K.}",
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Bae, Y, Park, C, Han, J, Hong, YJ, Song, HH, Shin, ES, Lee, JE, Han, BG, Jang, Y, Shin, DJ & Yoon, SK 2007, 'Interaction between GNB3 C825T and ACE I/D polymorphisms in essential hypertension in Koreans', Journal of Human Hypertension, vol. 21, no. 2, pp. 159-166. https://doi.org/10.1038/sj.jhh.1002110

Interaction between GNB3 C825T and ACE I/D polymorphisms in essential hypertension in Koreans. / Bae, Y.; Park, C.; Han, J.; Hong, Y. J.; Song, H. H.; Shin, E. S.; Lee, J. E.; Han, B. G.; Jang, Y.; Shin, D. J.; Yoon, S. K.

In: Journal of Human Hypertension, Vol. 21, No. 2, 01.02.2007, p. 159-166.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Interaction between GNB3 C825T and ACE I/D polymorphisms in essential hypertension in Koreans

AU - Bae, Y.

AU - Park, C.

AU - Han, J.

AU - Hong, Y. J.

AU - Song, H. H.

AU - Shin, E. S.

AU - Lee, J. E.

AU - Han, B. G.

AU - Jang, Y.

AU - Shin, D. J.

AU - Yoon, S. K.

PY - 2007/2/1

Y1 - 2007/2/1

N2 - Essential hypertension (EH) is considered a typical polygenic disease, so the evaluation of gene-gene interactions rather than the determination of single gene effects is crucial to understanding any genetic influences. The G-protein β3-subunit (GNB3) 825T allele, associated with enhanced G-protein signalling, is a strong candidate for interactions with polymorphisms, such as insertion/deletion (I/D) polymorphism of angiotensin I-converting enzyme (ACE) gene. We investigated whether there is an association between GNB3 C825T and ACE I/D polymorphisms for the development of EH. We carried out a case-control study of 688 hypertensive and 924 normotensive subjects recruited from South Korea. The GNB3 C825T and ACE I/D genotypes were determined by polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism methods, respectively. The distributions of alleles and genotypes for the GNB3 C825T and ACE I/D polymorphisms were not found to be significantly associated with hypertensive status in either males or females. Logistic regression analysis indicated that the GNB3 825T allele carriers were positively associated with EH in males (odds ratio (OR) for TT/CT, 1.459; 95% confidence interval (CI), 1.048-2.033, P=0.0255). In analysis of gene-gene interaction, we found that there was a significant interaction between the GNB3 825T and ACE D alleles (P<0.05). OR for EH was significantly higher in 825T allele carriers with ACE D allele (OR, 1.490; 95% CI, 1.117-1.987, P=0.0067). A significant interaction between the GNB3 825T and the ACE D alleles may contribute to the predisposing effect for the development of EH in Koreans.

AB - Essential hypertension (EH) is considered a typical polygenic disease, so the evaluation of gene-gene interactions rather than the determination of single gene effects is crucial to understanding any genetic influences. The G-protein β3-subunit (GNB3) 825T allele, associated with enhanced G-protein signalling, is a strong candidate for interactions with polymorphisms, such as insertion/deletion (I/D) polymorphism of angiotensin I-converting enzyme (ACE) gene. We investigated whether there is an association between GNB3 C825T and ACE I/D polymorphisms for the development of EH. We carried out a case-control study of 688 hypertensive and 924 normotensive subjects recruited from South Korea. The GNB3 C825T and ACE I/D genotypes were determined by polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism methods, respectively. The distributions of alleles and genotypes for the GNB3 C825T and ACE I/D polymorphisms were not found to be significantly associated with hypertensive status in either males or females. Logistic regression analysis indicated that the GNB3 825T allele carriers were positively associated with EH in males (odds ratio (OR) for TT/CT, 1.459; 95% confidence interval (CI), 1.048-2.033, P=0.0255). In analysis of gene-gene interaction, we found that there was a significant interaction between the GNB3 825T and ACE D alleles (P<0.05). OR for EH was significantly higher in 825T allele carriers with ACE D allele (OR, 1.490; 95% CI, 1.117-1.987, P=0.0067). A significant interaction between the GNB3 825T and the ACE D alleles may contribute to the predisposing effect for the development of EH in Koreans.

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