Interaction of single- and double-stranded DNA with multilayer MXene by fluorescence spectroscopy and molecular dynamics simulations

C. Lorena Manzanares-Palenzuela, Amir M. Pourrahimi, J. Gonzalez-Julian, Zdenek Sofer, Martin Pykal, Michal Otyepka, Martin Pumera

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The integration of nucleic acids with nanomaterials has attracted great attention from various research communities in search of new nanoscale tools for a range of applications, from electronics to biomedical uses. MXenes are a new class of multielement 2D materials baring exciting properties mostly directed to energy-related fields. These advanced materials are now beginning to enter the biomedical field given their biocompatibility, hydrophilicity and near-infrared absorption. Herein, we elucidate the interaction of MXene Ti3C2Tx with fluorophore-tagged DNA by fluorescence measurements and molecular dynamics simulations. The system showed potential for biosensing with unequivocal detection at picomole levels and single-base discrimination. We found that this material possesses a kinetically unique entrapment/release behavior, with potential implications in time-controlled biomolecule delivery. Our findings present MXenes as platforms for binding nucleic acids, contributing to their potential for hybridization-based biosensing and related bio-applications.

Original languageEnglish
Pages (from-to)10010-10017
Number of pages8
JournalChemical Science
Volume10
Issue number43
DOIs
Publication statusPublished - 2019 Jan 1

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Single-Stranded DNA
Fluorescence spectroscopy
Molecular dynamics
Multilayers
Nucleic Acids
DNA
Computer simulation
Fluorophores
Hydrophilicity
Infrared absorption
Biomolecules
Biocompatibility
Nanostructured materials
Electronic equipment
Fluorescence

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

Manzanares-Palenzuela, C. L., Pourrahimi, A. M., Gonzalez-Julian, J., Sofer, Z., Pykal, M., Otyepka, M., & Pumera, M. (2019). Interaction of single- and double-stranded DNA with multilayer MXene by fluorescence spectroscopy and molecular dynamics simulations. Chemical Science, 10(43), 10010-10017. https://doi.org/10.1039/c9sc03049b
Manzanares-Palenzuela, C. Lorena ; Pourrahimi, Amir M. ; Gonzalez-Julian, J. ; Sofer, Zdenek ; Pykal, Martin ; Otyepka, Michal ; Pumera, Martin. / Interaction of single- and double-stranded DNA with multilayer MXene by fluorescence spectroscopy and molecular dynamics simulations. In: Chemical Science. 2019 ; Vol. 10, No. 43. pp. 10010-10017.
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Manzanares-Palenzuela, CL, Pourrahimi, AM, Gonzalez-Julian, J, Sofer, Z, Pykal, M, Otyepka, M & Pumera, M 2019, 'Interaction of single- and double-stranded DNA with multilayer MXene by fluorescence spectroscopy and molecular dynamics simulations', Chemical Science, vol. 10, no. 43, pp. 10010-10017. https://doi.org/10.1039/c9sc03049b

Interaction of single- and double-stranded DNA with multilayer MXene by fluorescence spectroscopy and molecular dynamics simulations. / Manzanares-Palenzuela, C. Lorena; Pourrahimi, Amir M.; Gonzalez-Julian, J.; Sofer, Zdenek; Pykal, Martin; Otyepka, Michal; Pumera, Martin.

In: Chemical Science, Vol. 10, No. 43, 01.01.2019, p. 10010-10017.

Research output: Contribution to journalArticle

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AU - Pumera, Martin

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Manzanares-Palenzuela CL, Pourrahimi AM, Gonzalez-Julian J, Sofer Z, Pykal M, Otyepka M et al. Interaction of single- and double-stranded DNA with multilayer MXene by fluorescence spectroscopy and molecular dynamics simulations. Chemical Science. 2019 Jan 1;10(43):10010-10017. https://doi.org/10.1039/c9sc03049b