Interactions among stratum corneum defensive functions

Peter M. Elias, Eung Ho Choi

Research output: Contribution to journalReview article

134 Citations (Scopus)

Abstract

With the exception of vitamin D production, virtually all epidermal functions can be considered as protective, or more specifically, as defensive in nature (1). Yet, the term "barrier function" of the stratum corneum (SC) is often used synonymously with only one such defensive function, although arguably its most important, i.e., permeability barrier homeostasis. Regardless of their hierarchy of relative importance, these critical protective functions largely reside in the SC. In this short review, we explore the ways in which the multiple defensive functions of the SC are linked and interrelated, either by their shared localization or by common biochemical processes.

Original languageEnglish
Pages (from-to)719-726
Number of pages8
JournalExperimental Dermatology
Volume14
Issue number10
DOIs
Publication statusPublished - 2005 Oct 1

Fingerprint

Cornea
Biochemical Phenomena
Vitamin D
Permeability
Homeostasis

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Elias, Peter M. ; Choi, Eung Ho. / Interactions among stratum corneum defensive functions. In: Experimental Dermatology. 2005 ; Vol. 14, No. 10. pp. 719-726.
@article{4cffbfbbe6394a50a01934d0308d6074,
title = "Interactions among stratum corneum defensive functions",
abstract = "With the exception of vitamin D production, virtually all epidermal functions can be considered as protective, or more specifically, as defensive in nature (1). Yet, the term {"}barrier function{"} of the stratum corneum (SC) is often used synonymously with only one such defensive function, although arguably its most important, i.e., permeability barrier homeostasis. Regardless of their hierarchy of relative importance, these critical protective functions largely reside in the SC. In this short review, we explore the ways in which the multiple defensive functions of the SC are linked and interrelated, either by their shared localization or by common biochemical processes.",
author = "Elias, {Peter M.} and Choi, {Eung Ho}",
year = "2005",
month = "10",
day = "1",
doi = "10.1111/j.1600-0625.2005.00363.x",
language = "English",
volume = "14",
pages = "719--726",
journal = "Experimental Dermatology",
issn = "0906-6705",
publisher = "Wiley-Blackwell",
number = "10",

}

Interactions among stratum corneum defensive functions. / Elias, Peter M.; Choi, Eung Ho.

In: Experimental Dermatology, Vol. 14, No. 10, 01.10.2005, p. 719-726.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Interactions among stratum corneum defensive functions

AU - Elias, Peter M.

AU - Choi, Eung Ho

PY - 2005/10/1

Y1 - 2005/10/1

N2 - With the exception of vitamin D production, virtually all epidermal functions can be considered as protective, or more specifically, as defensive in nature (1). Yet, the term "barrier function" of the stratum corneum (SC) is often used synonymously with only one such defensive function, although arguably its most important, i.e., permeability barrier homeostasis. Regardless of their hierarchy of relative importance, these critical protective functions largely reside in the SC. In this short review, we explore the ways in which the multiple defensive functions of the SC are linked and interrelated, either by their shared localization or by common biochemical processes.

AB - With the exception of vitamin D production, virtually all epidermal functions can be considered as protective, or more specifically, as defensive in nature (1). Yet, the term "barrier function" of the stratum corneum (SC) is often used synonymously with only one such defensive function, although arguably its most important, i.e., permeability barrier homeostasis. Regardless of their hierarchy of relative importance, these critical protective functions largely reside in the SC. In this short review, we explore the ways in which the multiple defensive functions of the SC are linked and interrelated, either by their shared localization or by common biochemical processes.

UR - http://www.scopus.com/inward/record.url?scp=26444486975&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=26444486975&partnerID=8YFLogxK

U2 - 10.1111/j.1600-0625.2005.00363.x

DO - 10.1111/j.1600-0625.2005.00363.x

M3 - Review article

VL - 14

SP - 719

EP - 726

JO - Experimental Dermatology

JF - Experimental Dermatology

SN - 0906-6705

IS - 10

ER -