Interactions of a tetraanionic porphyrin with DNA: From a Z-DNA sensor to a versatile supramolecular device

Alessandro D'Urso; Angela Mammana; Milan Balaz; Andrea E. Holmes; Nina Berova; Rosaria Lauceri; Roberto Purrello

doi:10.1021/ja808099u

Interactions of a tetraanionic porphyrin with DNA: From a Z-DNA sensor to a versatile supramolecular device

Alessandro D'Urso, Angela Mammana, Milan Balaz, Andrea E. Holmes, Nina Berova, Rosaria Lauceri, Roberto Purrello

Integrated Sciences and Engineering Division

Research output: Contribution to journal › Article › peer-review

114 Citations (Scopus)

Abstract

The anionic nickel(II) porphyrin NiTPPS is able to selectively sense the spermine induced left-handed Z-form of DNA while it is completely silent in the presence of right-handed B-DNA. Interactions between the DNA and the porphyrin can be easily modulated by pH and temperature. The resulting Z-DNA-porphyrin-spermine complex behaves as a supramolecular reversible information storage system and as a reversible AND logic gate.

Original language	English
Pages (from-to)	2046-2047
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	131
Issue number	6
DOIs	https://doi.org/10.1021/ja808099u
Publication status	Published - 2009 Feb 18

All Science Journal Classification (ASJC) codes

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja808099u

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AU - Balaz, Milan

AU - Holmes, Andrea E.

AU - Berova, Nina

AU - Lauceri, Rosaria

AU - Purrello, Roberto

PY - 2009/2/18

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AB - The anionic nickel(II) porphyrin NiTPPS is able to selectively sense the spermine induced left-handed Z-form of DNA while it is completely silent in the presence of right-handed B-DNA. Interactions between the DNA and the porphyrin can be easily modulated by pH and temperature. The resulting Z-DNA-porphyrin-spermine complex behaves as a supramolecular reversible information storage system and as a reversible AND logic gate.

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Interactions of a tetraanionic porphyrin with DNA: From a Z-DNA sensor to a versatile supramolecular device

Abstract

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