Interictal epileptiform discharges relate to 1H-MRS-detected metabolic abnormalities in mesial temporal lobe epilepsy

Sun Ah Park, Gyu Sik Kim, Seung Koo Lee, Sung Ryoung Lim, Kyoung Heo, Soo Chul Park, JinWoo Chang, Dong Ik Kim, Byung In Lee

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Abstract

Purpose: To examine whether the distribution of interictal epileptiform discharges (IEDs) recorded from foramen ovale electrodes (FOEs) correlates with metabolite levels in medial structures of the temporal lobes in patients with mesial temporal lobe epilepsy (MTLE). Methods: We studied 34 patients with MTLE. The lateralization ratio of IEDs was calculated after counting IEDs recorded from FOEs during prolonged video-EEG monitoring. Metabolite ratio between N-acetylaspartate (NAA) and creatine (Cr) was calculated in each medial temporal structure. The correlation between the lateralization ratio of IEDs and metabolic ratio was evaluated. Results: The asymmetry indexes of IEDs correlated with the asymmetry index of NAA/Cr ratio in the medial temporal structure (p = -0.380; p = 0.027). Analysis of IEDs and metabolite ratio revealed a significant inverse relation in the contralateral side to the major epileptogenic focus (p = -0.360; p = 0.037); however, this significance was not present in the ipsilateral side (p = -0.018; p = 0.921). Conclusions: There is a correlation between the neuronal dysfunction or damage detected by MRS and the epileptic activity in the contralateral medial temporal structure. Our results suggest that the pathomechanism underlying the contralateral reduction of NAA/Cr ratio, frequently observed in patients with MTLE, might be related to the process of epileptogenesis generating the independent contralateral IEDs.

Original languageEnglish
Pages (from-to)1385-1389
Number of pages5
JournalEpilepsia
Volume43
Issue number11
DOIs
Publication statusPublished - 2002 Nov 1

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Temporal Lobe Epilepsy
Creatine
Foramen Ovale
Electrodes
Temporal Lobe
Electroencephalography
N-acetylaspartate
Proton Magnetic Resonance Spectroscopy

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Park, S. A., Kim, G. S., Lee, S. K., Lim, S. R., Heo, K., Park, S. C., ... Lee, B. I. (2002). Interictal epileptiform discharges relate to 1H-MRS-detected metabolic abnormalities in mesial temporal lobe epilepsy. Epilepsia, 43(11), 1385-1389. https://doi.org/10.1046/j.1528-1157.2002.29901.x
Park, Sun Ah ; Kim, Gyu Sik ; Lee, Seung Koo ; Lim, Sung Ryoung ; Heo, Kyoung ; Park, Soo Chul ; Chang, JinWoo ; Kim, Dong Ik ; Lee, Byung In. / Interictal epileptiform discharges relate to 1H-MRS-detected metabolic abnormalities in mesial temporal lobe epilepsy. In: Epilepsia. 2002 ; Vol. 43, No. 11. pp. 1385-1389.
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abstract = "Purpose: To examine whether the distribution of interictal epileptiform discharges (IEDs) recorded from foramen ovale electrodes (FOEs) correlates with metabolite levels in medial structures of the temporal lobes in patients with mesial temporal lobe epilepsy (MTLE). Methods: We studied 34 patients with MTLE. The lateralization ratio of IEDs was calculated after counting IEDs recorded from FOEs during prolonged video-EEG monitoring. Metabolite ratio between N-acetylaspartate (NAA) and creatine (Cr) was calculated in each medial temporal structure. The correlation between the lateralization ratio of IEDs and metabolic ratio was evaluated. Results: The asymmetry indexes of IEDs correlated with the asymmetry index of NAA/Cr ratio in the medial temporal structure (p = -0.380; p = 0.027). Analysis of IEDs and metabolite ratio revealed a significant inverse relation in the contralateral side to the major epileptogenic focus (p = -0.360; p = 0.037); however, this significance was not present in the ipsilateral side (p = -0.018; p = 0.921). Conclusions: There is a correlation between the neuronal dysfunction or damage detected by MRS and the epileptic activity in the contralateral medial temporal structure. Our results suggest that the pathomechanism underlying the contralateral reduction of NAA/Cr ratio, frequently observed in patients with MTLE, might be related to the process of epileptogenesis generating the independent contralateral IEDs.",
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Interictal epileptiform discharges relate to 1H-MRS-detected metabolic abnormalities in mesial temporal lobe epilepsy. / Park, Sun Ah; Kim, Gyu Sik; Lee, Seung Koo; Lim, Sung Ryoung; Heo, Kyoung; Park, Soo Chul; Chang, JinWoo; Kim, Dong Ik; Lee, Byung In.

In: Epilepsia, Vol. 43, No. 11, 01.11.2002, p. 1385-1389.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Interictal epileptiform discharges relate to 1H-MRS-detected metabolic abnormalities in mesial temporal lobe epilepsy

AU - Park, Sun Ah

AU - Kim, Gyu Sik

AU - Lee, Seung Koo

AU - Lim, Sung Ryoung

AU - Heo, Kyoung

AU - Park, Soo Chul

AU - Chang, JinWoo

AU - Kim, Dong Ik

AU - Lee, Byung In

PY - 2002/11/1

Y1 - 2002/11/1

N2 - Purpose: To examine whether the distribution of interictal epileptiform discharges (IEDs) recorded from foramen ovale electrodes (FOEs) correlates with metabolite levels in medial structures of the temporal lobes in patients with mesial temporal lobe epilepsy (MTLE). Methods: We studied 34 patients with MTLE. The lateralization ratio of IEDs was calculated after counting IEDs recorded from FOEs during prolonged video-EEG monitoring. Metabolite ratio between N-acetylaspartate (NAA) and creatine (Cr) was calculated in each medial temporal structure. The correlation between the lateralization ratio of IEDs and metabolic ratio was evaluated. Results: The asymmetry indexes of IEDs correlated with the asymmetry index of NAA/Cr ratio in the medial temporal structure (p = -0.380; p = 0.027). Analysis of IEDs and metabolite ratio revealed a significant inverse relation in the contralateral side to the major epileptogenic focus (p = -0.360; p = 0.037); however, this significance was not present in the ipsilateral side (p = -0.018; p = 0.921). Conclusions: There is a correlation between the neuronal dysfunction or damage detected by MRS and the epileptic activity in the contralateral medial temporal structure. Our results suggest that the pathomechanism underlying the contralateral reduction of NAA/Cr ratio, frequently observed in patients with MTLE, might be related to the process of epileptogenesis generating the independent contralateral IEDs.

AB - Purpose: To examine whether the distribution of interictal epileptiform discharges (IEDs) recorded from foramen ovale electrodes (FOEs) correlates with metabolite levels in medial structures of the temporal lobes in patients with mesial temporal lobe epilepsy (MTLE). Methods: We studied 34 patients with MTLE. The lateralization ratio of IEDs was calculated after counting IEDs recorded from FOEs during prolonged video-EEG monitoring. Metabolite ratio between N-acetylaspartate (NAA) and creatine (Cr) was calculated in each medial temporal structure. The correlation between the lateralization ratio of IEDs and metabolic ratio was evaluated. Results: The asymmetry indexes of IEDs correlated with the asymmetry index of NAA/Cr ratio in the medial temporal structure (p = -0.380; p = 0.027). Analysis of IEDs and metabolite ratio revealed a significant inverse relation in the contralateral side to the major epileptogenic focus (p = -0.360; p = 0.037); however, this significance was not present in the ipsilateral side (p = -0.018; p = 0.921). Conclusions: There is a correlation between the neuronal dysfunction or damage detected by MRS and the epileptic activity in the contralateral medial temporal structure. Our results suggest that the pathomechanism underlying the contralateral reduction of NAA/Cr ratio, frequently observed in patients with MTLE, might be related to the process of epileptogenesis generating the independent contralateral IEDs.

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SP - 1385

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