Interim estimates of the effectiveness of the influenza vaccine against A(H3N2) influenza in adults in South Korea, 2016-2017 season

Ji Yun Noh, Sooyeon Lim, Joon Young Song, Won Suk Choi, Hye Won Jeong, Jung Yeon Heo, Jacob Lee, Yu Bin Seo, Jin Soo Lee, Seong Heon Wie, Young Keun Kim, Kyung Hwa Park, Sook In Jung, Shin Woo Kim, Sun Hee Lee, Han Sol Lee, Young Hoon Yoon, Hee Jin Cheong, Woo Joo Kim

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

In the 2016-2017 season, the A(H3N2) influenza epidemic presented an unusual early peak pattern compared with past seasons in South Korea. The interim vaccine effectiveness (VE) of influenza vaccination in preventing laboratory-confirmed influenza was estimated using test-negative design through the tertiary hospital-based influenza surveillance system in South Korea. From 1 September, 2016 to 7 January, 2017, adjusted VE of influenza vaccination in preventing laboratory-confirmed A(H3N2) was -52.1% (95% confidence interval [CI], -147.2 to 6.4); -70.0% (95% CI, -212.0 to 7.4) in 19-64 years and 4.3% (95% CI, -137.8 to 61.5) in the elderly. Circulating A(H3N2) viruses belonged to the three phylogenetic subclades of 3C.2a, differently to A/Hong Kong/4801/2014, the current vaccine strain. Amino acid substitutions in hemagglutinin of circulating viruses seem to contribute to low VE. In conclusion, interim VE analysis presented that the protection of laboratory-confirmed influenza by seasonal influenza vaccination did not show the statistical significance in South Korea in the 2016-2017 influenza season.

Original languageEnglish
Article numbere0178010
JournalPloS one
Volume12
Issue number5
DOIs
Publication statusPublished - 2017 May

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Republic of Korea
Influenza Vaccines
South Korea
influenza
Human Influenza
Vaccines
vaccines
Viruses
Vaccination
Hemagglutinins
Confidence Intervals
confidence interval
vaccination
Substitution reactions
H3N2 Subtype Influenza A Virus
Amino Acids
Hong Kong
Amino Acid Substitution
Tertiary Care Centers
amino acid substitution

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Noh, Ji Yun ; Lim, Sooyeon ; Song, Joon Young ; Choi, Won Suk ; Jeong, Hye Won ; Heo, Jung Yeon ; Lee, Jacob ; Seo, Yu Bin ; Lee, Jin Soo ; Wie, Seong Heon ; Kim, Young Keun ; Park, Kyung Hwa ; Jung, Sook In ; Kim, Shin Woo ; Lee, Sun Hee ; Lee, Han Sol ; Yoon, Young Hoon ; Cheong, Hee Jin ; Kim, Woo Joo. / Interim estimates of the effectiveness of the influenza vaccine against A(H3N2) influenza in adults in South Korea, 2016-2017 season. In: PloS one. 2017 ; Vol. 12, No. 5.
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title = "Interim estimates of the effectiveness of the influenza vaccine against A(H3N2) influenza in adults in South Korea, 2016-2017 season",
abstract = "In the 2016-2017 season, the A(H3N2) influenza epidemic presented an unusual early peak pattern compared with past seasons in South Korea. The interim vaccine effectiveness (VE) of influenza vaccination in preventing laboratory-confirmed influenza was estimated using test-negative design through the tertiary hospital-based influenza surveillance system in South Korea. From 1 September, 2016 to 7 January, 2017, adjusted VE of influenza vaccination in preventing laboratory-confirmed A(H3N2) was -52.1{\%} (95{\%} confidence interval [CI], -147.2 to 6.4); -70.0{\%} (95{\%} CI, -212.0 to 7.4) in 19-64 years and 4.3{\%} (95{\%} CI, -137.8 to 61.5) in the elderly. Circulating A(H3N2) viruses belonged to the three phylogenetic subclades of 3C.2a, differently to A/Hong Kong/4801/2014, the current vaccine strain. Amino acid substitutions in hemagglutinin of circulating viruses seem to contribute to low VE. In conclusion, interim VE analysis presented that the protection of laboratory-confirmed influenza by seasonal influenza vaccination did not show the statistical significance in South Korea in the 2016-2017 influenza season.",
author = "Noh, {Ji Yun} and Sooyeon Lim and Song, {Joon Young} and Choi, {Won Suk} and Jeong, {Hye Won} and Heo, {Jung Yeon} and Jacob Lee and Seo, {Yu Bin} and Lee, {Jin Soo} and Wie, {Seong Heon} and Kim, {Young Keun} and Park, {Kyung Hwa} and Jung, {Sook In} and Kim, {Shin Woo} and Lee, {Sun Hee} and Lee, {Han Sol} and Yoon, {Young Hoon} and Cheong, {Hee Jin} and Kim, {Woo Joo}",
year = "2017",
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Noh, JY, Lim, S, Song, JY, Choi, WS, Jeong, HW, Heo, JY, Lee, J, Seo, YB, Lee, JS, Wie, SH, Kim, YK, Park, KH, Jung, SI, Kim, SW, Lee, SH, Lee, HS, Yoon, YH, Cheong, HJ & Kim, WJ 2017, 'Interim estimates of the effectiveness of the influenza vaccine against A(H3N2) influenza in adults in South Korea, 2016-2017 season', PloS one, vol. 12, no. 5, e0178010. https://doi.org/10.1371/journal.pone.0178010

Interim estimates of the effectiveness of the influenza vaccine against A(H3N2) influenza in adults in South Korea, 2016-2017 season. / Noh, Ji Yun; Lim, Sooyeon; Song, Joon Young; Choi, Won Suk; Jeong, Hye Won; Heo, Jung Yeon; Lee, Jacob; Seo, Yu Bin; Lee, Jin Soo; Wie, Seong Heon; Kim, Young Keun; Park, Kyung Hwa; Jung, Sook In; Kim, Shin Woo; Lee, Sun Hee; Lee, Han Sol; Yoon, Young Hoon; Cheong, Hee Jin; Kim, Woo Joo.

In: PloS one, Vol. 12, No. 5, e0178010, 05.2017.

Research output: Contribution to journalArticle

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T1 - Interim estimates of the effectiveness of the influenza vaccine against A(H3N2) influenza in adults in South Korea, 2016-2017 season

AU - Noh, Ji Yun

AU - Lim, Sooyeon

AU - Song, Joon Young

AU - Choi, Won Suk

AU - Jeong, Hye Won

AU - Heo, Jung Yeon

AU - Lee, Jacob

AU - Seo, Yu Bin

AU - Lee, Jin Soo

AU - Wie, Seong Heon

AU - Kim, Young Keun

AU - Park, Kyung Hwa

AU - Jung, Sook In

AU - Kim, Shin Woo

AU - Lee, Sun Hee

AU - Lee, Han Sol

AU - Yoon, Young Hoon

AU - Cheong, Hee Jin

AU - Kim, Woo Joo

PY - 2017/5

Y1 - 2017/5

N2 - In the 2016-2017 season, the A(H3N2) influenza epidemic presented an unusual early peak pattern compared with past seasons in South Korea. The interim vaccine effectiveness (VE) of influenza vaccination in preventing laboratory-confirmed influenza was estimated using test-negative design through the tertiary hospital-based influenza surveillance system in South Korea. From 1 September, 2016 to 7 January, 2017, adjusted VE of influenza vaccination in preventing laboratory-confirmed A(H3N2) was -52.1% (95% confidence interval [CI], -147.2 to 6.4); -70.0% (95% CI, -212.0 to 7.4) in 19-64 years and 4.3% (95% CI, -137.8 to 61.5) in the elderly. Circulating A(H3N2) viruses belonged to the three phylogenetic subclades of 3C.2a, differently to A/Hong Kong/4801/2014, the current vaccine strain. Amino acid substitutions in hemagglutinin of circulating viruses seem to contribute to low VE. In conclusion, interim VE analysis presented that the protection of laboratory-confirmed influenza by seasonal influenza vaccination did not show the statistical significance in South Korea in the 2016-2017 influenza season.

AB - In the 2016-2017 season, the A(H3N2) influenza epidemic presented an unusual early peak pattern compared with past seasons in South Korea. The interim vaccine effectiveness (VE) of influenza vaccination in preventing laboratory-confirmed influenza was estimated using test-negative design through the tertiary hospital-based influenza surveillance system in South Korea. From 1 September, 2016 to 7 January, 2017, adjusted VE of influenza vaccination in preventing laboratory-confirmed A(H3N2) was -52.1% (95% confidence interval [CI], -147.2 to 6.4); -70.0% (95% CI, -212.0 to 7.4) in 19-64 years and 4.3% (95% CI, -137.8 to 61.5) in the elderly. Circulating A(H3N2) viruses belonged to the three phylogenetic subclades of 3C.2a, differently to A/Hong Kong/4801/2014, the current vaccine strain. Amino acid substitutions in hemagglutinin of circulating viruses seem to contribute to low VE. In conclusion, interim VE analysis presented that the protection of laboratory-confirmed influenza by seasonal influenza vaccination did not show the statistical significance in South Korea in the 2016-2017 influenza season.

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