Interleukin-1β induced by Helicobacter pylori infection enhances mouse gastric carcinogenesis

Yasuyuki Shigematsu, Tohru Niwa, Emil Rehnberg, Takeshi Toyoda, Satoshi Yoshida, Akiko Mori, Mika Wakabayashi, Yoichiro Iwakura, Masao Ichinose, Yong Joon Kim, Toshikazu Ushijima

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Abstract

Interleukin-1β (Il1b) is considered to be involved in Helicobacter pylori (HP)-induced human gastric carcinogenesis, while the role of its polymorphisms in gastric cancer susceptibility remains controversial. Here, we aimed to clarify the role of HP infection-induced IL1B in gastric inflammation and carcinogenesis using Il1b-/- (Il1b-null) mice. In gastric mucosa of the Il1b+/+ (WT) mice, HP infection induced Il1b expression and severe inflammation. In contrast, in Il1b-null mice, recruitment of neutrophils and macrophages by HP infection was markedly suppressed. In a carcinogenicity test, the multiplicity of gastric tumors was significantly suppressed in the. Il1b-null mice (58% of WT; P<. 0.005). Mechanistically, HP infection induced NF-κB activation both in the inflammatory and epithelial cells in gastric mucosae, and the activation was attenuated in the Il1b-null mice. Accordingly, increased proliferation and decreased apoptosis of gastric epithelial cells induced by HP infection in the WT mice were attenuated in the Il1b-null mice. These results demonstrated that the IL1B physiologically induced by HP infection enhanced gastric carcinogenesis by affecting both inflammatory and epithelial cells.

Original languageEnglish
Pages (from-to)141-147
Number of pages7
JournalCancer Letters
Volume340
Issue number1
DOIs
Publication statusPublished - 2013 Oct 28

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Helicobacter Infections
Interleukin-1
Helicobacter pylori
Stomach
Carcinogenesis
Epithelial Cells
Gastric Mucosa
Carcinogenicity Tests
Inflammation
Neutrophil Infiltration
Stomach Neoplasms
Macrophages
Apoptosis
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Shigematsu, Y., Niwa, T., Rehnberg, E., Toyoda, T., Yoshida, S., Mori, A., ... Ushijima, T. (2013). Interleukin-1β induced by Helicobacter pylori infection enhances mouse gastric carcinogenesis. Cancer Letters, 340(1), 141-147. https://doi.org/10.1016/j.canlet.2013.07.034
Shigematsu, Yasuyuki ; Niwa, Tohru ; Rehnberg, Emil ; Toyoda, Takeshi ; Yoshida, Satoshi ; Mori, Akiko ; Wakabayashi, Mika ; Iwakura, Yoichiro ; Ichinose, Masao ; Kim, Yong Joon ; Ushijima, Toshikazu. / Interleukin-1β induced by Helicobacter pylori infection enhances mouse gastric carcinogenesis. In: Cancer Letters. 2013 ; Vol. 340, No. 1. pp. 141-147.
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abstract = "Interleukin-1β (Il1b) is considered to be involved in Helicobacter pylori (HP)-induced human gastric carcinogenesis, while the role of its polymorphisms in gastric cancer susceptibility remains controversial. Here, we aimed to clarify the role of HP infection-induced IL1B in gastric inflammation and carcinogenesis using Il1b-/- (Il1b-null) mice. In gastric mucosa of the Il1b+/+ (WT) mice, HP infection induced Il1b expression and severe inflammation. In contrast, in Il1b-null mice, recruitment of neutrophils and macrophages by HP infection was markedly suppressed. In a carcinogenicity test, the multiplicity of gastric tumors was significantly suppressed in the. Il1b-null mice (58{\%} of WT; P<. 0.005). Mechanistically, HP infection induced NF-κB activation both in the inflammatory and epithelial cells in gastric mucosae, and the activation was attenuated in the Il1b-null mice. Accordingly, increased proliferation and decreased apoptosis of gastric epithelial cells induced by HP infection in the WT mice were attenuated in the Il1b-null mice. These results demonstrated that the IL1B physiologically induced by HP infection enhanced gastric carcinogenesis by affecting both inflammatory and epithelial cells.",
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Shigematsu, Y, Niwa, T, Rehnberg, E, Toyoda, T, Yoshida, S, Mori, A, Wakabayashi, M, Iwakura, Y, Ichinose, M, Kim, YJ & Ushijima, T 2013, 'Interleukin-1β induced by Helicobacter pylori infection enhances mouse gastric carcinogenesis', Cancer Letters, vol. 340, no. 1, pp. 141-147. https://doi.org/10.1016/j.canlet.2013.07.034

Interleukin-1β induced by Helicobacter pylori infection enhances mouse gastric carcinogenesis. / Shigematsu, Yasuyuki; Niwa, Tohru; Rehnberg, Emil; Toyoda, Takeshi; Yoshida, Satoshi; Mori, Akiko; Wakabayashi, Mika; Iwakura, Yoichiro; Ichinose, Masao; Kim, Yong Joon; Ushijima, Toshikazu.

In: Cancer Letters, Vol. 340, No. 1, 28.10.2013, p. 141-147.

Research output: Contribution to journalArticle

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AU - Shigematsu, Yasuyuki

AU - Niwa, Tohru

AU - Rehnberg, Emil

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AU - Yoshida, Satoshi

AU - Mori, Akiko

AU - Wakabayashi, Mika

AU - Iwakura, Yoichiro

AU - Ichinose, Masao

AU - Kim, Yong Joon

AU - Ushijima, Toshikazu

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Y1 - 2013/10/28

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