Interleukin-1β induced by Helicobacter pylori infection enhances mouse gastric carcinogenesis

Yasuyuki Shigematsu, Tohru Niwa, Emil Rehnberg, Takeshi Toyoda, Satoshi Yoshida, Akiko Mori, Mika Wakabayashi, Yoichiro Iwakura, Masao Ichinose, Young-Joon Kim, Toshikazu Ushijima

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37 Citations (Scopus)

Abstract

Interleukin-1β (Il1b) is considered to be involved in Helicobacter pylori (HP)-induced human gastric carcinogenesis, while the role of its polymorphisms in gastric cancer susceptibility remains controversial. Here, we aimed to clarify the role of HP infection-induced IL1B in gastric inflammation and carcinogenesis using Il1b-/- (Il1b-null) mice. In gastric mucosa of the Il1b+/+ (WT) mice, HP infection induced Il1b expression and severe inflammation. In contrast, in Il1b-null mice, recruitment of neutrophils and macrophages by HP infection was markedly suppressed. In a carcinogenicity test, the multiplicity of gastric tumors was significantly suppressed in the. Il1b-null mice (58% of WT; P<. 0.005). Mechanistically, HP infection induced NF-κB activation both in the inflammatory and epithelial cells in gastric mucosae, and the activation was attenuated in the Il1b-null mice. Accordingly, increased proliferation and decreased apoptosis of gastric epithelial cells induced by HP infection in the WT mice were attenuated in the Il1b-null mice. These results demonstrated that the IL1B physiologically induced by HP infection enhanced gastric carcinogenesis by affecting both inflammatory and epithelial cells.

Original languageEnglish
Pages (from-to)141-147
Number of pages7
JournalCancer Letters
Volume340
Issue number1
DOIs
Publication statusPublished - 2013 Oct 28

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Helicobacter Infections
Interleukin-1
Helicobacter pylori
Stomach
Carcinogenesis
Epithelial Cells
Gastric Mucosa
Carcinogenicity Tests
Inflammation
Neutrophil Infiltration
Stomach Neoplasms
Macrophages
Apoptosis
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Shigematsu, Y., Niwa, T., Rehnberg, E., Toyoda, T., Yoshida, S., Mori, A., ... Ushijima, T. (2013). Interleukin-1β induced by Helicobacter pylori infection enhances mouse gastric carcinogenesis. Cancer Letters, 340(1), 141-147. https://doi.org/10.1016/j.canlet.2013.07.034
Shigematsu, Yasuyuki ; Niwa, Tohru ; Rehnberg, Emil ; Toyoda, Takeshi ; Yoshida, Satoshi ; Mori, Akiko ; Wakabayashi, Mika ; Iwakura, Yoichiro ; Ichinose, Masao ; Kim, Young-Joon ; Ushijima, Toshikazu. / Interleukin-1β induced by Helicobacter pylori infection enhances mouse gastric carcinogenesis. In: Cancer Letters. 2013 ; Vol. 340, No. 1. pp. 141-147.
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abstract = "Interleukin-1β (Il1b) is considered to be involved in Helicobacter pylori (HP)-induced human gastric carcinogenesis, while the role of its polymorphisms in gastric cancer susceptibility remains controversial. Here, we aimed to clarify the role of HP infection-induced IL1B in gastric inflammation and carcinogenesis using Il1b-/- (Il1b-null) mice. In gastric mucosa of the Il1b+/+ (WT) mice, HP infection induced Il1b expression and severe inflammation. In contrast, in Il1b-null mice, recruitment of neutrophils and macrophages by HP infection was markedly suppressed. In a carcinogenicity test, the multiplicity of gastric tumors was significantly suppressed in the. Il1b-null mice (58{\%} of WT; P<. 0.005). Mechanistically, HP infection induced NF-κB activation both in the inflammatory and epithelial cells in gastric mucosae, and the activation was attenuated in the Il1b-null mice. Accordingly, increased proliferation and decreased apoptosis of gastric epithelial cells induced by HP infection in the WT mice were attenuated in the Il1b-null mice. These results demonstrated that the IL1B physiologically induced by HP infection enhanced gastric carcinogenesis by affecting both inflammatory and epithelial cells.",
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Shigematsu, Y, Niwa, T, Rehnberg, E, Toyoda, T, Yoshida, S, Mori, A, Wakabayashi, M, Iwakura, Y, Ichinose, M, Kim, Y-J & Ushijima, T 2013, 'Interleukin-1β induced by Helicobacter pylori infection enhances mouse gastric carcinogenesis', Cancer Letters, vol. 340, no. 1, pp. 141-147. https://doi.org/10.1016/j.canlet.2013.07.034

Interleukin-1β induced by Helicobacter pylori infection enhances mouse gastric carcinogenesis. / Shigematsu, Yasuyuki; Niwa, Tohru; Rehnberg, Emil; Toyoda, Takeshi; Yoshida, Satoshi; Mori, Akiko; Wakabayashi, Mika; Iwakura, Yoichiro; Ichinose, Masao; Kim, Young-Joon; Ushijima, Toshikazu.

In: Cancer Letters, Vol. 340, No. 1, 28.10.2013, p. 141-147.

Research output: Contribution to journalArticle

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AU - Shigematsu, Yasuyuki

AU - Niwa, Tohru

AU - Rehnberg, Emil

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AU - Yoshida, Satoshi

AU - Mori, Akiko

AU - Wakabayashi, Mika

AU - Iwakura, Yoichiro

AU - Ichinose, Masao

AU - Kim, Young-Joon

AU - Ushijima, Toshikazu

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Y1 - 2013/10/28

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