Background: The role of interleukin-20 (IL-20) in tumor migration remains to be elucidated. Results: IL-20 induces cell migration via ERK1/2-mediated NF-B/MMP-9 regulation by inducing p21WAF1 expression. Conclusion: p21WAF1 is essential for the cell migration induced by IL-20. Significance: This work provides novel insights into the molecular events of IL-20-mediated cancer cell migration indicating it is dependent on p21WAF1 expression.
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology