Interleukin-20 promotes migration of bladder cancer cells through extracellular signal-regulated kinase (erk)-mediated mmp-9 protein expression leading to nuclear factor (nf-kb) activation by inducing the up-regulation of p21waf1 protein expression

Se Jung Lee, Seok Cheol Cho, Eo Jin Lee, Sangtae Kim, Soo Bok Lee, Jung Hyurk Lim, Yung Hyun Choi, Wun Jae Kim, Sung Kwon Moon

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Background: The role of interleukin-20 (IL-20) in tumor migration remains to be elucidated. Results: IL-20 induces cell migration via ERK1/2-mediated NF-B/MMP-9 regulation by inducing p21WAF1 expression. Conclusion: p21WAF1 is essential for the cell migration induced by IL-20. Significance: This work provides novel insights into the molecular events of IL-20-mediated cancer cell migration indicating it is dependent on p21WAF1 expression.

Original languageEnglish
Pages (from-to)5539-5552
Number of pages14
JournalJournal of Biological Chemistry
Volume288
Issue number8
DOIs
Publication statusPublished - 2013 Feb 22

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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