Interleukin-20 promotes migration of bladder cancer cells through extracellular signal-regulated kinase (erk)-mediated mmp-9 protein expression leading to nuclear factor (nf-kb) activation by inducing the up-regulation of p21waf1 protein expression

Se Jung Lee, Seok Cheol Cho, Eo Jin Lee, Sangtae Kim, Soo Bok Lee, Jung Hyurk Lim, Yung Hyun Choi, Wun Jae Kim, Sung Kwon Moon

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Background: The role of interleukin-20 (IL-20) in tumor migration remains to be elucidated. Results: IL-20 induces cell migration via ERK1/2-mediated NF-B/MMP-9 regulation by inducing p21WAF1 expression. Conclusion: p21WAF1 is essential for the cell migration induced by IL-20. Significance: This work provides novel insights into the molecular events of IL-20-mediated cancer cell migration indicating it is dependent on p21WAF1 expression.

Original languageEnglish
Pages (from-to)5539-5552
Number of pages14
JournalJournal of Biological Chemistry
Volume288
Issue number8
DOIs
Publication statusPublished - 2013 Feb 22

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Extracellular Signal-Regulated MAP Kinases
Urinary Bladder Neoplasms
Up-Regulation
Chemical activation
Cells
Cell Movement
Proteins
Matrix Metalloproteinases
Tumors
Neoplasms
interleukin 20

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

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title = "Interleukin-20 promotes migration of bladder cancer cells through extracellular signal-regulated kinase (erk)-mediated mmp-9 protein expression leading to nuclear factor (nf-kb) activation by inducing the up-regulation of p21waf1 protein expression",
abstract = "Background: The role of interleukin-20 (IL-20) in tumor migration remains to be elucidated. Results: IL-20 induces cell migration via ERK1/2-mediated NF-B/MMP-9 regulation by inducing p21WAF1 expression. Conclusion: p21WAF1 is essential for the cell migration induced by IL-20. Significance: This work provides novel insights into the molecular events of IL-20-mediated cancer cell migration indicating it is dependent on p21WAF1 expression.",
author = "Lee, {Se Jung} and Cho, {Seok Cheol} and Lee, {Eo Jin} and Sangtae Kim and Lee, {Soo Bok} and Lim, {Jung Hyurk} and Choi, {Yung Hyun} and Kim, {Wun Jae} and Moon, {Sung Kwon}",
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}

Interleukin-20 promotes migration of bladder cancer cells through extracellular signal-regulated kinase (erk)-mediated mmp-9 protein expression leading to nuclear factor (nf-kb) activation by inducing the up-regulation of p21waf1 protein expression. / Lee, Se Jung; Cho, Seok Cheol; Lee, Eo Jin; Kim, Sangtae; Lee, Soo Bok; Lim, Jung Hyurk; Choi, Yung Hyun; Kim, Wun Jae; Moon, Sung Kwon.

In: Journal of Biological Chemistry, Vol. 288, No. 8, 22.02.2013, p. 5539-5552.

Research output: Contribution to journalArticle

TY - JOUR

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AU - Lee, Se Jung

AU - Cho, Seok Cheol

AU - Lee, Eo Jin

AU - Kim, Sangtae

AU - Lee, Soo Bok

AU - Lim, Jung Hyurk

AU - Choi, Yung Hyun

AU - Kim, Wun Jae

AU - Moon, Sung Kwon

PY - 2013/2/22

Y1 - 2013/2/22

N2 - Background: The role of interleukin-20 (IL-20) in tumor migration remains to be elucidated. Results: IL-20 induces cell migration via ERK1/2-mediated NF-B/MMP-9 regulation by inducing p21WAF1 expression. Conclusion: p21WAF1 is essential for the cell migration induced by IL-20. Significance: This work provides novel insights into the molecular events of IL-20-mediated cancer cell migration indicating it is dependent on p21WAF1 expression.

AB - Background: The role of interleukin-20 (IL-20) in tumor migration remains to be elucidated. Results: IL-20 induces cell migration via ERK1/2-mediated NF-B/MMP-9 regulation by inducing p21WAF1 expression. Conclusion: p21WAF1 is essential for the cell migration induced by IL-20. Significance: This work provides novel insights into the molecular events of IL-20-mediated cancer cell migration indicating it is dependent on p21WAF1 expression.

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