Interleukin-4 inhibits the vascular endothelial growth factor- and basic fibroblast growth factor-induced angiogenesis in vitro

In Yong Lee, Jinkoo Kim, Eun Mi Ko, Euh Jun Jeoung, Young Guen Kwon, Jongseon Choe

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The role of interleukin-4 (IL-4) in the inflammatory process has emerged recently. In this study, we investigated the effect of IL-4 on the angiogenic process in an in vitro experimental system. IL-4 significantly inhibited the proliferation of human umbilical vein endothelial cells (HUVEC) that was induced by the vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF). VEGF- or bFGF-induced HUVEC chemotaxis was abrogated by the IL-4 treatment. In addition, the formation of tube-like structures by HUVEC in the presence of VEGF or bFGF was also severely down-regulated by IL-4. The inhibitory effects on the critical steps of angiogenesis were not observed with IL-6 that is abundantly found in the inflamed tissue. Our results suggest that IL-4 may play a regulatory role in normal physiology and provide the potential possibility for IL-4 as a therapeutic agent in the intervention of angiogenesis-related diseases.

Original languageEnglish
Pages (from-to)115-121
Number of pages7
JournalMolecules and cells
Volume14
Issue number1
Publication statusPublished - 2002 Aug 1

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

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