Interleukin-4 inhibits the vascular endothelial growth factor- and basic fibroblast growth factor-induced angiogenesis in vitro

In Yong Lee, Jinkoo Kim, Eun Mi Ko, Euh Jun Jeoung, Young-Guen Kwon, Jongseon Choe

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The role of interleukin-4 (IL-4) in the inflammatory process has emerged recently. In this study, we investigated the effect of IL-4 on the angiogenic process in an in vitro experimental system. IL-4 significantly inhibited the proliferation of human umbilical vein endothelial cells (HUVEC) that was induced by the vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF). VEGF- or bFGF-induced HUVEC chemotaxis was abrogated by the IL-4 treatment. In addition, the formation of tube-like structures by HUVEC in the presence of VEGF or bFGF was also severely down-regulated by IL-4. The inhibitory effects on the critical steps of angiogenesis were not observed with IL-6 that is abundantly found in the inflamed tissue. Our results suggest that IL-4 may play a regulatory role in normal physiology and provide the potential possibility for IL-4 as a therapeutic agent in the intervention of angiogenesis-related diseases.

Original languageEnglish
Pages (from-to)115-121
Number of pages7
JournalMolecules and cells
Volume14
Issue number1
Publication statusPublished - 2002 Aug 1

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Fibroblast Growth Factor 2
Interleukin-4
Vascular Endothelial Growth Factor A
Human Umbilical Vein Endothelial Cells
Chemotaxis
In Vitro Techniques
Interleukin-6
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Lee, In Yong ; Kim, Jinkoo ; Ko, Eun Mi ; Jeoung, Euh Jun ; Kwon, Young-Guen ; Choe, Jongseon. / Interleukin-4 inhibits the vascular endothelial growth factor- and basic fibroblast growth factor-induced angiogenesis in vitro. In: Molecules and cells. 2002 ; Vol. 14, No. 1. pp. 115-121.
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abstract = "The role of interleukin-4 (IL-4) in the inflammatory process has emerged recently. In this study, we investigated the effect of IL-4 on the angiogenic process in an in vitro experimental system. IL-4 significantly inhibited the proliferation of human umbilical vein endothelial cells (HUVEC) that was induced by the vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF). VEGF- or bFGF-induced HUVEC chemotaxis was abrogated by the IL-4 treatment. In addition, the formation of tube-like structures by HUVEC in the presence of VEGF or bFGF was also severely down-regulated by IL-4. The inhibitory effects on the critical steps of angiogenesis were not observed with IL-6 that is abundantly found in the inflamed tissue. Our results suggest that IL-4 may play a regulatory role in normal physiology and provide the potential possibility for IL-4 as a therapeutic agent in the intervention of angiogenesis-related diseases.",
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Interleukin-4 inhibits the vascular endothelial growth factor- and basic fibroblast growth factor-induced angiogenesis in vitro. / Lee, In Yong; Kim, Jinkoo; Ko, Eun Mi; Jeoung, Euh Jun; Kwon, Young-Guen; Choe, Jongseon.

In: Molecules and cells, Vol. 14, No. 1, 01.08.2002, p. 115-121.

Research output: Contribution to journalArticle

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AB - The role of interleukin-4 (IL-4) in the inflammatory process has emerged recently. In this study, we investigated the effect of IL-4 on the angiogenic process in an in vitro experimental system. IL-4 significantly inhibited the proliferation of human umbilical vein endothelial cells (HUVEC) that was induced by the vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF). VEGF- or bFGF-induced HUVEC chemotaxis was abrogated by the IL-4 treatment. In addition, the formation of tube-like structures by HUVEC in the presence of VEGF or bFGF was also severely down-regulated by IL-4. The inhibitory effects on the critical steps of angiogenesis were not observed with IL-6 that is abundantly found in the inflamed tissue. Our results suggest that IL-4 may play a regulatory role in normal physiology and provide the potential possibility for IL-4 as a therapeutic agent in the intervention of angiogenesis-related diseases.

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