Interleukin-6-572C>G polymorphism-association with inflammatory variables in Korean men with coronary artery disease

Yangsoo Jang, Oh Yoen Kim, Yae Jung Hyun, Jey Sook Chae, Soo Jeong Koh, Yu Mi Heo, Donghoon Choi, Dong Jik Shin, Kenneth Huttner, Jong Ho Lee

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Abstract

Growing evidence suggests that polymorphisms at position -174 and -572 in interleukin-6 (IL-6) gene are associated with various manifestations of atherosclerosis. We investigated the genotype effects of IL-6 -174 and -572 polymorphisms on circulating levels of inflammatory markers in Korean men with coronary artery disease (CAD). CAD patients were subdivided into 2 groups; those patients treated without lipid-lowering drug (LLD) (n = 173) and those treated with LLD (n = 353). No significant differences existed between the 2 groups in age, body mass index, blood pressure, serum glucose, alcohol consumption, cigarette smoking, and the proportions of antihypertensive and antiplatelet therapies. IL-6 - 572 C>G polymorphism was only observed in this population. In CAD patients not taking LLD, the G/G genotype of the -572C>G polymorphism was associated with greater concentrations of IL-6 (C/C: 4.1 ± 0.8 pg/mL, C/G: 3.7 ± 0.7, G/G: 12.4 ± 6.6; P = 0.031), C-reactive protein (CRP) (C/C: 1.9 ± 0.4 mg/dL, C/G: 2.7 ± 0.8, G/G: 10.1 ± 3.9; P = 0.002), fibrinogen (C/C: 334 ± 6 mg/dL, C/G: 345 ± 13, G/G: 429 ± 38; P = 0.003), and oxidized low-density lipoprotein (ox-LDL) (C/C: 59 ± 2 mg/dL, C/G: 55 ± 3, G/G: 71 ± 6; P = 0.041) than those with C/C or C/G. However, in the LLD group, no difference existed in circulating levels of IL-6, CRP, fibrinogen, and ox-LDL across the genotype after adjustment of age. This study suggests that circulating levels of IL-6 and its related proteins such as CRP and fibrinogen are associated with genotype at a promoter polymorphism (-572C>G) of the IL-6 gene in Korean men with CAD not taking LLD. LLD, mostly statin in this study, might reduce the exaggeration of G/G genotype-raising effect on inflammatory markers.

Original languageEnglish
Pages (from-to)154-161
Number of pages8
JournalTranslational Research
Volume151
Issue number3
DOIs
Publication statusPublished - 2008 Jan 1

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All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Biochemistry, medical

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