Abstract
Objective: Increased levels of inflammatory markers, such as interleukin-6 (IL-6), are associated with type 2 diabetes (T2DM). We investigated the association of IL-6 gene polymorphisms with T2DM and circulating levels of IL-6 in Koreans. Subjects: A total of 1477 subjects with normal glucose tolerance and 476 T2DM patients were included. Measurements: We examined IL-6 -174G→C, -572C→G, -597G→A and -1363G→T promoter region polymorphisms. The main outcome measures were the odds ratio (OR) on T2DM risk and serum concentrations of IL-6 and high-sensitivity C-reactive protein (hs-CRP). Results: Homozygosity for the rare G allele IL-6 -572C→G was associated with a higher risk of T2DM [OR 1.69 (95%CI 1.11-2.58), P = 0.015]. Serum IL-6 concentrations were associated with the IL-6 -572C→G genotype in control subjects (G/G: 2.33 ± 0.41: C/G: 1.53 ± 0.09: C/C: 1.72 ± 0.08 ng/l, P = 0.023). Also in the control group, subjects homozygous for the rare G allele showed significantly higher concentrations of hs-CRP than C/C and C/G carriers (G/G: 13.6 ± 2.9: C/G: 9.2 ± 0.6: C/C: 7.8 ± 0.4 mg/l, P = 0.003). The C-allele at the IL-6 -174 SNP was very rare (< 0.01) and -597G→A and -1363G→T were monomorphic in this population. Conclusions: Our data demonstrate that the IL-6 -572G/G genotype is associated with higher serum IL-6 and hs-CRP concentrations and with increased risk for T2DM.
| Original language | English |
|---|---|
| Pages (from-to) | 238-244 |
| Number of pages | 7 |
| Journal | Clinical Endocrinology |
| Volume | 70 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2009 Feb 1 |
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All Science Journal Classification (ASJC) codes
- Endocrinology, Diabetes and Metabolism
- Endocrinology
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Interleukin-6 (IL-6) -572C→G promoter polymorphism is associated with type 2 diabetes risk in Koreans. / Koh, Soo Jeong; Jang, Yangsoo; Hyun, Yae Jung; Park, Ju Yeon; Song, Young Duk; Shin, Kyung Kyun; Chae, Jey Sook; Kim, Byung Keuk; Ordovas, Jose M.; Lee, Jong Ho.
In: Clinical Endocrinology, Vol. 70, No. 2, 01.02.2009, p. 238-244.Research output: Contribution to journal › Article
TY - JOUR
T1 - Interleukin-6 (IL-6) -572C→G promoter polymorphism is associated with type 2 diabetes risk in Koreans
AU - Koh, Soo Jeong
AU - Jang, Yangsoo
AU - Hyun, Yae Jung
AU - Park, Ju Yeon
AU - Song, Young Duk
AU - Shin, Kyung Kyun
AU - Chae, Jey Sook
AU - Kim, Byung Keuk
AU - Ordovas, Jose M.
AU - Lee, Jong Ho
PY - 2009/2/1
Y1 - 2009/2/1
N2 - Objective: Increased levels of inflammatory markers, such as interleukin-6 (IL-6), are associated with type 2 diabetes (T2DM). We investigated the association of IL-6 gene polymorphisms with T2DM and circulating levels of IL-6 in Koreans. Subjects: A total of 1477 subjects with normal glucose tolerance and 476 T2DM patients were included. Measurements: We examined IL-6 -174G→C, -572C→G, -597G→A and -1363G→T promoter region polymorphisms. The main outcome measures were the odds ratio (OR) on T2DM risk and serum concentrations of IL-6 and high-sensitivity C-reactive protein (hs-CRP). Results: Homozygosity for the rare G allele IL-6 -572C→G was associated with a higher risk of T2DM [OR 1.69 (95%CI 1.11-2.58), P = 0.015]. Serum IL-6 concentrations were associated with the IL-6 -572C→G genotype in control subjects (G/G: 2.33 ± 0.41: C/G: 1.53 ± 0.09: C/C: 1.72 ± 0.08 ng/l, P = 0.023). Also in the control group, subjects homozygous for the rare G allele showed significantly higher concentrations of hs-CRP than C/C and C/G carriers (G/G: 13.6 ± 2.9: C/G: 9.2 ± 0.6: C/C: 7.8 ± 0.4 mg/l, P = 0.003). The C-allele at the IL-6 -174 SNP was very rare (< 0.01) and -597G→A and -1363G→T were monomorphic in this population. Conclusions: Our data demonstrate that the IL-6 -572G/G genotype is associated with higher serum IL-6 and hs-CRP concentrations and with increased risk for T2DM.
AB - Objective: Increased levels of inflammatory markers, such as interleukin-6 (IL-6), are associated with type 2 diabetes (T2DM). We investigated the association of IL-6 gene polymorphisms with T2DM and circulating levels of IL-6 in Koreans. Subjects: A total of 1477 subjects with normal glucose tolerance and 476 T2DM patients were included. Measurements: We examined IL-6 -174G→C, -572C→G, -597G→A and -1363G→T promoter region polymorphisms. The main outcome measures were the odds ratio (OR) on T2DM risk and serum concentrations of IL-6 and high-sensitivity C-reactive protein (hs-CRP). Results: Homozygosity for the rare G allele IL-6 -572C→G was associated with a higher risk of T2DM [OR 1.69 (95%CI 1.11-2.58), P = 0.015]. Serum IL-6 concentrations were associated with the IL-6 -572C→G genotype in control subjects (G/G: 2.33 ± 0.41: C/G: 1.53 ± 0.09: C/C: 1.72 ± 0.08 ng/l, P = 0.023). Also in the control group, subjects homozygous for the rare G allele showed significantly higher concentrations of hs-CRP than C/C and C/G carriers (G/G: 13.6 ± 2.9: C/G: 9.2 ± 0.6: C/C: 7.8 ± 0.4 mg/l, P = 0.003). The C-allele at the IL-6 -174 SNP was very rare (< 0.01) and -597G→A and -1363G→T were monomorphic in this population. Conclusions: Our data demonstrate that the IL-6 -572G/G genotype is associated with higher serum IL-6 and hs-CRP concentrations and with increased risk for T2DM.
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U2 - 10.1111/j.1365-2265.2008.03315.x
DO - 10.1111/j.1365-2265.2008.03315.x
M3 - Article
C2 - 18573122
AN - SCOPUS:58549086336
VL - 70
SP - 238
EP - 244
JO - Clinical Endocrinology
JF - Clinical Endocrinology
SN - 0300-0664
IS - 2
ER -