Interleukin-6 (IL-6) -572C→G promoter polymorphism is associated with type 2 diabetes risk in Koreans

Soo Jeong Koh, Yangsoo Jang, Yae Jung Hyun, Ju Yeon Park, Young Duk Song, Kyung Kyun Shin, Jey Sook Chae, Byung Keuk Kim, Jose M. Ordovas, Jong Ho Lee

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Abstract

Objective: Increased levels of inflammatory markers, such as interleukin-6 (IL-6), are associated with type 2 diabetes (T2DM). We investigated the association of IL-6 gene polymorphisms with T2DM and circulating levels of IL-6 in Koreans. Subjects: A total of 1477 subjects with normal glucose tolerance and 476 T2DM patients were included. Measurements: We examined IL-6 -174G→C, -572C→G, -597G→A and -1363G→T promoter region polymorphisms. The main outcome measures were the odds ratio (OR) on T2DM risk and serum concentrations of IL-6 and high-sensitivity C-reactive protein (hs-CRP). Results: Homozygosity for the rare G allele IL-6 -572C→G was associated with a higher risk of T2DM [OR 1.69 (95%CI 1.11-2.58), P = 0.015]. Serum IL-6 concentrations were associated with the IL-6 -572C→G genotype in control subjects (G/G: 2.33 ± 0.41: C/G: 1.53 ± 0.09: C/C: 1.72 ± 0.08 ng/l, P = 0.023). Also in the control group, subjects homozygous for the rare G allele showed significantly higher concentrations of hs-CRP than C/C and C/G carriers (G/G: 13.6 ± 2.9: C/G: 9.2 ± 0.6: C/C: 7.8 ± 0.4 mg/l, P = 0.003). The C-allele at the IL-6 -174 SNP was very rare (< 0.01) and -597G→A and -1363G→T were monomorphic in this population. Conclusions: Our data demonstrate that the IL-6 -572G/G genotype is associated with higher serum IL-6 and hs-CRP concentrations and with increased risk for T2DM.

Original languageEnglish
Pages (from-to)238-244
Number of pages7
JournalClinical Endocrinology
Volume70
Issue number2
DOIs
Publication statusPublished - 2009 Feb 1

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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    Koh, S. J., Jang, Y., Hyun, Y. J., Park, J. Y., Song, Y. D., Shin, K. K., Chae, J. S., Kim, B. K., Ordovas, J. M., & Lee, J. H. (2009). Interleukin-6 (IL-6) -572C→G promoter polymorphism is associated with type 2 diabetes risk in Koreans. Clinical Endocrinology, 70(2), 238-244. https://doi.org/10.1111/j.1365-2265.2008.03315.x