Intermolecular hydroacylation by transition-metal complexes

Chul Ho Jun, Eun Ae Jo, Jung Woo Park

Research output: Contribution to journalShort survey

174 Citations (Scopus)

Abstract

In this review, transition-metal-catalyzed intermolecular hydroacylation, which is a direct synthetic protocol generating ketones from aldehydes and unsaturated hydrocarbons, will be discussed. In order to avoid decarbonylation, one of the major side-reactions occurring in transition-metal-catalyzed hydroacylation, several important strategies have been developed: An aldehyde ligand bearing a coordinating heteroatom at an appropriate position, a chelation auxiliary, and a masked form of the aldehyde, such as an aldimine or allylamine. Hydroacylation or its variations can also be applied to the synthesis of cycloalkanones and an α,β-unsaturated ketone or to the carbon-carbon triple bond cleavage of an alkyne.

Original languageEnglish
Pages (from-to)1869-1881
Number of pages13
JournalEuropean Journal of Organic Chemistry
Issue number12
DOIs
Publication statusPublished - 2007

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Organic Chemistry

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