Internal mammary node irradiation in node-positive breast cancer treated with mastectomy and taxane-based chemotherapy

Won Kyung Cho, Jee Suk Chang, Seung Gyu Park, Nalee Kim, Doo Ho Choi, Haeyoung Kim, Yong Bae Kim, Won Park, Chang Ok Suh

Research output: Contribution to journalArticlepeer-review

Abstract

Background: It is important to continually reevaluate the risk/benefit calculus of internal mammary node irradiation (IMNI) in the era of modern systemic therapy. We aimed to investigate the effect of IMNI on survival in node-positive breast cancer treated with mastectomy and anthracycline plus taxane-based chemotherapy. Methods: We analyzed 348 patients who underwent mastectomy and anthracycline plus taxane-based chemotherapy for node-positive breast cancer between January 2006 and December 2011. All patients received postoperative radiation therapy (RT) with IMNI (n = 105, 30.2%) or without IMNI (n = 243, 69.8%). The benefit of IMNI for disease-free survival (DFS) and overall survival (OS) was evaluated using multivariate analysis and inverse probability of treatment weighting (IPTW) to adjust for unbalanced covariates between the groups. Results: After a median follow-up of 95 months, the 10-year locoregional recurrence-free survival rate, DFS, and OS in all patients were 94.8%, 77.4%, and 86.2%, respectively. The IPTW-adjusted hazard ratio (HR) for the association of IMNI (vs. no IMNI) with DFS and OS was 0.208 (95% confidence intervals (CI) 0.045–0.966) and 0.460 (95% CI, 0.220–0.962), respectively. In multivariate analysis, IMNI was a favorable factor for DFS (HR, 0.458; P = 0.021) and OS (HR 0.233, P = 0.018). Conclusions: IMNI was associated with improved DFS and OS in node-positive patients treated with mastectomy, post-mastectomy RT, and taxane-based chemotherapy, although the rate of locoregional recurrence was low.

Original languageEnglish
Pages (from-to)37-43
Number of pages7
JournalBreast
Volume59
DOIs
Publication statusPublished - 2021 Oct

Bibliographical note

Funding Information:
This study was supported by a grant from the National R&D Program for Cancer Control , Ministry of Health &Welfare , Republic of Korea (grant number: HA17C0043 ).

Funding Information:
This study was supported by a grant from the National R&D Program for Cancer Control, Ministry of Health &Welfare, Republic of Korea (grant number: HA17C0043).

Publisher Copyright:
© 2021

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology
  • Cancer Research

Fingerprint

Dive into the research topics of 'Internal mammary node irradiation in node-positive breast cancer treated with mastectomy and taxane-based chemotherapy'. Together they form a unique fingerprint.

Cite this