Interobservervariabilität in Abgrenzung zum makroskopischen Tumorvolumen für hepatozelluläre Karzinome: Ergebnisse der Korean Radiation Oncology Group 1207 Study

Translated title of the contribution: Interobserver variability in gross tumor volume delineation for hepatocellular carcinoma: Results of Korean Radiation Oncology Group 1207 study

Young Suk Kim, Jun Won Kim, Won Sup Yoon, Min Kyu Kang, Ik Jae Lee, Tae Hyun Kim, Jin Hee Kim, Hyung Sik Lee, Hee Chul Park, Hong Seok Jang, Chul Seung Kay, Sang Min Yoon, Mi Sook Kim, Jinsil Seong

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Purpose: There has been increasing use of external beam radiotherapy for localized treatment of hepatocellular carcinoma (HCC) with both palliative and curative intent. Quality control of target delineation in primary HCC is essential to deliver adequate doses of radiation to the primary tumor while preserving adjacent healthy organs. We analyzed interobserver variability in gross tumor volume (GTV) delineation for HCC. Patients and methods: Twelve radiation oncologists specializing in liver malignancy participated in a multi-institutional contouring dummy-run study of nine HCC cases and independently delineated GTV on the same set of provided computed tomography images. Quantitative analysis was performed using an expectation maximization algorithm for simultaneous truth and performance level estimation (STAPLE) with kappa statistics calculating agreement between physicians. To quantify the interobserver variability of GTV delineations, the ratio of the actual delineated volume to the estimated consensus volume (STAPLE), the ratio of the common and encompassing volumes, and the coefficient of variation were calculated. Results: The median kappa agreement level was 0.71 (range 0.28–0.86). The ratio of the actual delineated volume to the estimated consensus volume ranged from 0.19 to 1.93 (median 0.94) for all cases. The ratio of the common and encompassing volumes ranged from 0.001 to 0.56 (median 0.25). The coefficient of variation for GTV delineation ranged from 8 to 57 % (median 26 %). Conclusion: The interobserver variability in target delineation of HCC GTV in this study is noteworthy. Multi-institution studies involving radiotherapy for HCC require appropriate quality assurance programs for target delineation.

Original languageGerman
Pages (from-to)714-721
Number of pages8
JournalStrahlentherapie und Onkologie
Volume192
Issue number10
DOIs
Publication statusPublished - 2016 Oct 1

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Radiation Oncology
Observer Variation
Tumor Burden
Hepatocellular Carcinoma
Radiotherapy
Quality Control
Neoplasms
Tomography
Radiation
Physicians
Liver

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Oncology

Cite this

Kim, Young Suk ; Kim, Jun Won ; Yoon, Won Sup ; Kang, Min Kyu ; Lee, Ik Jae ; Kim, Tae Hyun ; Kim, Jin Hee ; Lee, Hyung Sik ; Park, Hee Chul ; Jang, Hong Seok ; Kay, Chul Seung ; Yoon, Sang Min ; Kim, Mi Sook ; Seong, Jinsil. / Interobservervariabilität in Abgrenzung zum makroskopischen Tumorvolumen für hepatozelluläre Karzinome : Ergebnisse der Korean Radiation Oncology Group 1207 Study. In: Strahlentherapie und Onkologie. 2016 ; Vol. 192, No. 10. pp. 714-721.
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abstract = "Purpose: There has been increasing use of external beam radiotherapy for localized treatment of hepatocellular carcinoma (HCC) with both palliative and curative intent. Quality control of target delineation in primary HCC is essential to deliver adequate doses of radiation to the primary tumor while preserving adjacent healthy organs. We analyzed interobserver variability in gross tumor volume (GTV) delineation for HCC. Patients and methods: Twelve radiation oncologists specializing in liver malignancy participated in a multi-institutional contouring dummy-run study of nine HCC cases and independently delineated GTV on the same set of provided computed tomography images. Quantitative analysis was performed using an expectation maximization algorithm for simultaneous truth and performance level estimation (STAPLE) with kappa statistics calculating agreement between physicians. To quantify the interobserver variability of GTV delineations, the ratio of the actual delineated volume to the estimated consensus volume (STAPLE), the ratio of the common and encompassing volumes, and the coefficient of variation were calculated. Results: The median kappa agreement level was 0.71 (range 0.28–0.86). The ratio of the actual delineated volume to the estimated consensus volume ranged from 0.19 to 1.93 (median 0.94) for all cases. The ratio of the common and encompassing volumes ranged from 0.001 to 0.56 (median 0.25). The coefficient of variation for GTV delineation ranged from 8 to 57 {\%} (median 26 {\%}). Conclusion: The interobserver variability in target delineation of HCC GTV in this study is noteworthy. Multi-institution studies involving radiotherapy for HCC require appropriate quality assurance programs for target delineation.",
author = "Kim, {Young Suk} and Kim, {Jun Won} and Yoon, {Won Sup} and Kang, {Min Kyu} and Lee, {Ik Jae} and Kim, {Tae Hyun} and Kim, {Jin Hee} and Lee, {Hyung Sik} and Park, {Hee Chul} and Jang, {Hong Seok} and Kay, {Chul Seung} and Yoon, {Sang Min} and Kim, {Mi Sook} and Jinsil Seong",
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Interobservervariabilität in Abgrenzung zum makroskopischen Tumorvolumen für hepatozelluläre Karzinome : Ergebnisse der Korean Radiation Oncology Group 1207 Study. / Kim, Young Suk; Kim, Jun Won; Yoon, Won Sup; Kang, Min Kyu; Lee, Ik Jae; Kim, Tae Hyun; Kim, Jin Hee; Lee, Hyung Sik; Park, Hee Chul; Jang, Hong Seok; Kay, Chul Seung; Yoon, Sang Min; Kim, Mi Sook; Seong, Jinsil.

In: Strahlentherapie und Onkologie, Vol. 192, No. 10, 01.10.2016, p. 714-721.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Interobservervariabilität in Abgrenzung zum makroskopischen Tumorvolumen für hepatozelluläre Karzinome

T2 - Ergebnisse der Korean Radiation Oncology Group 1207 Study

AU - Kim, Young Suk

AU - Kim, Jun Won

AU - Yoon, Won Sup

AU - Kang, Min Kyu

AU - Lee, Ik Jae

AU - Kim, Tae Hyun

AU - Kim, Jin Hee

AU - Lee, Hyung Sik

AU - Park, Hee Chul

AU - Jang, Hong Seok

AU - Kay, Chul Seung

AU - Yoon, Sang Min

AU - Kim, Mi Sook

AU - Seong, Jinsil

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Purpose: There has been increasing use of external beam radiotherapy for localized treatment of hepatocellular carcinoma (HCC) with both palliative and curative intent. Quality control of target delineation in primary HCC is essential to deliver adequate doses of radiation to the primary tumor while preserving adjacent healthy organs. We analyzed interobserver variability in gross tumor volume (GTV) delineation for HCC. Patients and methods: Twelve radiation oncologists specializing in liver malignancy participated in a multi-institutional contouring dummy-run study of nine HCC cases and independently delineated GTV on the same set of provided computed tomography images. Quantitative analysis was performed using an expectation maximization algorithm for simultaneous truth and performance level estimation (STAPLE) with kappa statistics calculating agreement between physicians. To quantify the interobserver variability of GTV delineations, the ratio of the actual delineated volume to the estimated consensus volume (STAPLE), the ratio of the common and encompassing volumes, and the coefficient of variation were calculated. Results: The median kappa agreement level was 0.71 (range 0.28–0.86). The ratio of the actual delineated volume to the estimated consensus volume ranged from 0.19 to 1.93 (median 0.94) for all cases. The ratio of the common and encompassing volumes ranged from 0.001 to 0.56 (median 0.25). The coefficient of variation for GTV delineation ranged from 8 to 57 % (median 26 %). Conclusion: The interobserver variability in target delineation of HCC GTV in this study is noteworthy. Multi-institution studies involving radiotherapy for HCC require appropriate quality assurance programs for target delineation.

AB - Purpose: There has been increasing use of external beam radiotherapy for localized treatment of hepatocellular carcinoma (HCC) with both palliative and curative intent. Quality control of target delineation in primary HCC is essential to deliver adequate doses of radiation to the primary tumor while preserving adjacent healthy organs. We analyzed interobserver variability in gross tumor volume (GTV) delineation for HCC. Patients and methods: Twelve radiation oncologists specializing in liver malignancy participated in a multi-institutional contouring dummy-run study of nine HCC cases and independently delineated GTV on the same set of provided computed tomography images. Quantitative analysis was performed using an expectation maximization algorithm for simultaneous truth and performance level estimation (STAPLE) with kappa statistics calculating agreement between physicians. To quantify the interobserver variability of GTV delineations, the ratio of the actual delineated volume to the estimated consensus volume (STAPLE), the ratio of the common and encompassing volumes, and the coefficient of variation were calculated. Results: The median kappa agreement level was 0.71 (range 0.28–0.86). The ratio of the actual delineated volume to the estimated consensus volume ranged from 0.19 to 1.93 (median 0.94) for all cases. The ratio of the common and encompassing volumes ranged from 0.001 to 0.56 (median 0.25). The coefficient of variation for GTV delineation ranged from 8 to 57 % (median 26 %). Conclusion: The interobserver variability in target delineation of HCC GTV in this study is noteworthy. Multi-institution studies involving radiotherapy for HCC require appropriate quality assurance programs for target delineation.

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U2 - 10.1007/s00066-016-1028-2

DO - 10.1007/s00066-016-1028-2

M3 - Article

C2 - 27538775

AN - SCOPUS:84982262087

VL - 192

SP - 714

EP - 721

JO - Strahlentherapie und Onkologie

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