Interplay of genetic and epigenetic alterations in hepatocellular carcinoma

Sun Min Lee, Jeongsil Kim-Ha, Won Young Choi, Jungwoo Lee, Dawon Kim, Jinyoung Lee, Eunji Choi, Young Joon Kim

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

Genetic and epigenetic alterations play prominent roles in hepatocarcinogenesis and their appearance varies depending on etiological factors, race and tumor progression. Intriguingly, distinct patterns of these genetic and epigenetic mutations are coupled not only to affect each other, but to trigger different types of tumorigenesis. The patterns and frequencies of somatic variations vary depending on the nature of the surrounding chromatin. On the other hand, epigenetic alterations often induce genomic instability prone to mutation. Therefore, genetic mutations and epigenetic alterations in hepatocellular carcinoma appear to be inseparable factors that accelerate tumorigenesis synergistically. We have summarized recent findings on genetic and epigenetic modifications, their influences on each other's alterations and putative roles in liver tumorigenesis.

Original languageEnglish
Pages (from-to)993-1005
Number of pages13
JournalEpigenomics
Volume8
Issue number7
DOIs
Publication statusPublished - 2016 Jul

All Science Journal Classification (ASJC) codes

  • Genetics
  • Cancer Research

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    Lee, S. M., Kim-Ha, J., Choi, W. Y., Lee, J., Kim, D., Lee, J., Choi, E., & Kim, Y. J. (2016). Interplay of genetic and epigenetic alterations in hepatocellular carcinoma. Epigenomics, 8(7), 993-1005. https://doi.org/10.2217/epi-2016-0027