Interplay of genetic and epigenetic alterations in hepatocellular carcinoma

Sun Min Lee, Jeongsil Kim-Ha, Won Young Choi, Jungwoo Lee, Dawon Kim, Jinyoung Lee, Eunji Choi, Young Joon Kim

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Genetic and epigenetic alterations play prominent roles in hepatocarcinogenesis and their appearance varies depending on etiological factors, race and tumor progression. Intriguingly, distinct patterns of these genetic and epigenetic mutations are coupled not only to affect each other, but to trigger different types of tumorigenesis. The patterns and frequencies of somatic variations vary depending on the nature of the surrounding chromatin. On the other hand, epigenetic alterations often induce genomic instability prone to mutation. Therefore, genetic mutations and epigenetic alterations in hepatocellular carcinoma appear to be inseparable factors that accelerate tumorigenesis synergistically. We have summarized recent findings on genetic and epigenetic modifications, their influences on each other's alterations and putative roles in liver tumorigenesis.

Original languageEnglish
Pages (from-to)993-1005
Number of pages13
JournalEpigenomics
Volume8
Issue number7
DOIs
Publication statusPublished - 2016 Jul

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Epigenomics
Hepatocellular Carcinoma
Carcinogenesis
Mutation
Genomic Instability
Chromatin
Liver
Neoplasms

All Science Journal Classification (ASJC) codes

  • Genetics
  • Cancer Research

Cite this

Lee, Sun Min ; Kim-Ha, Jeongsil ; Choi, Won Young ; Lee, Jungwoo ; Kim, Dawon ; Lee, Jinyoung ; Choi, Eunji ; Kim, Young Joon. / Interplay of genetic and epigenetic alterations in hepatocellular carcinoma. In: Epigenomics. 2016 ; Vol. 8, No. 7. pp. 993-1005.
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Lee, SM, Kim-Ha, J, Choi, WY, Lee, J, Kim, D, Lee, J, Choi, E & Kim, YJ 2016, 'Interplay of genetic and epigenetic alterations in hepatocellular carcinoma', Epigenomics, vol. 8, no. 7, pp. 993-1005. https://doi.org/10.2217/epi-2016-0027

Interplay of genetic and epigenetic alterations in hepatocellular carcinoma. / Lee, Sun Min; Kim-Ha, Jeongsil; Choi, Won Young; Lee, Jungwoo; Kim, Dawon; Lee, Jinyoung; Choi, Eunji; Kim, Young Joon.

In: Epigenomics, Vol. 8, No. 7, 07.2016, p. 993-1005.

Research output: Contribution to journalReview article

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Lee SM, Kim-Ha J, Choi WY, Lee J, Kim D, Lee J et al. Interplay of genetic and epigenetic alterations in hepatocellular carcinoma. Epigenomics. 2016 Jul;8(7):993-1005. https://doi.org/10.2217/epi-2016-0027