Helminth infection can alleviate immune-mediated disorders such as allergies and autoimmune diseases, by altering the gut microbiome. However, changes in gut microbiome due to intestinal trematodes remain unelucidated. Here, we evaluated the changes in the gut microbiome of ICR mice infected with Metagonimus yokogawai, a hypo-virulent intestinal trematode. Four weeks after infection, mouse cecal content was analyzed by 16S rRNA amplicon analysis. Although there was no apparent difference in species richness and diversity, the microbiome composition was different in the infected and control groups. Furthermore, several Lactobacillus species with known immunomodulatory role in immune-mediated diseases were increased in the infected group.
Bibliographical noteFunding Information:
This study was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean Government (MEST; number NRF-2016R1A2B4016194 and 2011-0012166).
This study was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean Government (MEST; number NRF- 2016R1A2B4016194 and 2011-0012166 ).
© 2018 Elsevier Inc.
All Science Journal Classification (ASJC) codes
- Infectious Diseases