Intestinal fluke Metagonimus yokogawai infection increases probiotic Lactobacillus in mouse cecum

Ju Yeong Kim, Eun Min Kim, Myung hee Yi, Jinyoung Lee, Seogwon Lee, Younjee Hwang, Dongeun Yong, Woon Mok Sohn, Tai Soon Yong

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Helminth infection can alleviate immune-mediated disorders such as allergies and autoimmune diseases, by altering the gut microbiome. However, changes in gut microbiome due to intestinal trematodes remain unelucidated. Here, we evaluated the changes in the gut microbiome of ICR mice infected with Metagonimus yokogawai, a hypo-virulent intestinal trematode. Four weeks after infection, mouse cecal content was analyzed by 16S rRNA amplicon analysis. Although there was no apparent difference in species richness and diversity, the microbiome composition was different in the infected and control groups. Furthermore, several Lactobacillus species with known immunomodulatory role in immune-mediated diseases were increased in the infected group.

Original languageEnglish
Pages (from-to)45-50
Number of pages6
JournalExperimental Parasitology
Volume193
DOIs
Publication statusPublished - 2018 Oct

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Immunology
  • Infectious Diseases

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