Intracoronary thrombus formation after drug-eluting stents implantation: Optical coherence tomographic study

Jung Sun Kim, Myeong Ki Hong, Chunyu Fan, Tae Hoon Kim, Jae Min Shim, Sang Min Park, Young Guk Ko, Donghoon Choi, Yangsoo Jang

Research output: Contribution to journalArticle

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Abstract

Background: Intracoronary thrombus formation after drug-eluting stent (DES) implantation is not sufficiently evaluated. Methods: Optical coherence tomography (OCT) was performed in 226 patients (total DES n = 244, sirolimus-eluting stent [SES] n = 95, paclitaxel-eluting stent [PES] n = 62, zotarolimus-eluting stent [ZES] n = 87) after implantation (mean 11 months, range 3-66 months). Using OCT, we investigated the incidence and determinants of intracoronary thrombus. Results: Intracoronary thrombus was detected in 35 (14%) cases (27 SES [28%], 7 PES [11%], and 1 ZES [1%], P < .001) and was associated with longer stent, smaller stent diameter, and stents at bifurcation lesions. More uncovered stent struts (26 ± 23 vs 8 ± 17, P < .001) and malapposed stent struts (6 ± 14 vs 2 ± 6, P < .001) were also associated with intracoronary thrombus. Multiple logistic regression analysis found the following determinants of intracoronary thrombus: stent length ≥28 mm (odds ratio [OR] 7.31, 95% CI 1.79-29.86, P = .01), stent diameter <3.0 mm (OR 4.38, 95% CI 1.38-13.97, P = .01), and ≥8 uncovered struts in each stent (OR 3.29, 95% CI 1.07-10.17, P = .04). Conclusions: Length, size, and types of DES may be more important than clinical factors in intracoronary thrombus formation after DES implantations.

Original languageEnglish
Pages (from-to)278-283
Number of pages6
JournalAmerican heart journal
Volume159
Issue number2
DOIs
Publication statusPublished - 2010 Feb 1

Fingerprint

Drug-Eluting Stents
Stents
Thrombosis
Odds Ratio
Optical Coherence Tomography
Sirolimus
Paclitaxel

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Kim, Jung Sun ; Hong, Myeong Ki ; Fan, Chunyu ; Kim, Tae Hoon ; Shim, Jae Min ; Park, Sang Min ; Ko, Young Guk ; Choi, Donghoon ; Jang, Yangsoo. / Intracoronary thrombus formation after drug-eluting stents implantation : Optical coherence tomographic study. In: American heart journal. 2010 ; Vol. 159, No. 2. pp. 278-283.
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abstract = "Background: Intracoronary thrombus formation after drug-eluting stent (DES) implantation is not sufficiently evaluated. Methods: Optical coherence tomography (OCT) was performed in 226 patients (total DES n = 244, sirolimus-eluting stent [SES] n = 95, paclitaxel-eluting stent [PES] n = 62, zotarolimus-eluting stent [ZES] n = 87) after implantation (mean 11 months, range 3-66 months). Using OCT, we investigated the incidence and determinants of intracoronary thrombus. Results: Intracoronary thrombus was detected in 35 (14{\%}) cases (27 SES [28{\%}], 7 PES [11{\%}], and 1 ZES [1{\%}], P < .001) and was associated with longer stent, smaller stent diameter, and stents at bifurcation lesions. More uncovered stent struts (26 ± 23 vs 8 ± 17, P < .001) and malapposed stent struts (6 ± 14 vs 2 ± 6, P < .001) were also associated with intracoronary thrombus. Multiple logistic regression analysis found the following determinants of intracoronary thrombus: stent length ≥28 mm (odds ratio [OR] 7.31, 95{\%} CI 1.79-29.86, P = .01), stent diameter <3.0 mm (OR 4.38, 95{\%} CI 1.38-13.97, P = .01), and ≥8 uncovered struts in each stent (OR 3.29, 95{\%} CI 1.07-10.17, P = .04). Conclusions: Length, size, and types of DES may be more important than clinical factors in intracoronary thrombus formation after DES implantations.",
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Intracoronary thrombus formation after drug-eluting stents implantation : Optical coherence tomographic study. / Kim, Jung Sun; Hong, Myeong Ki; Fan, Chunyu; Kim, Tae Hoon; Shim, Jae Min; Park, Sang Min; Ko, Young Guk; Choi, Donghoon; Jang, Yangsoo.

In: American heart journal, Vol. 159, No. 2, 01.02.2010, p. 278-283.

Research output: Contribution to journalArticle

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T1 - Intracoronary thrombus formation after drug-eluting stents implantation

T2 - Optical coherence tomographic study

AU - Kim, Jung Sun

AU - Hong, Myeong Ki

AU - Fan, Chunyu

AU - Kim, Tae Hoon

AU - Shim, Jae Min

AU - Park, Sang Min

AU - Ko, Young Guk

AU - Choi, Donghoon

AU - Jang, Yangsoo

PY - 2010/2/1

Y1 - 2010/2/1

N2 - Background: Intracoronary thrombus formation after drug-eluting stent (DES) implantation is not sufficiently evaluated. Methods: Optical coherence tomography (OCT) was performed in 226 patients (total DES n = 244, sirolimus-eluting stent [SES] n = 95, paclitaxel-eluting stent [PES] n = 62, zotarolimus-eluting stent [ZES] n = 87) after implantation (mean 11 months, range 3-66 months). Using OCT, we investigated the incidence and determinants of intracoronary thrombus. Results: Intracoronary thrombus was detected in 35 (14%) cases (27 SES [28%], 7 PES [11%], and 1 ZES [1%], P < .001) and was associated with longer stent, smaller stent diameter, and stents at bifurcation lesions. More uncovered stent struts (26 ± 23 vs 8 ± 17, P < .001) and malapposed stent struts (6 ± 14 vs 2 ± 6, P < .001) were also associated with intracoronary thrombus. Multiple logistic regression analysis found the following determinants of intracoronary thrombus: stent length ≥28 mm (odds ratio [OR] 7.31, 95% CI 1.79-29.86, P = .01), stent diameter <3.0 mm (OR 4.38, 95% CI 1.38-13.97, P = .01), and ≥8 uncovered struts in each stent (OR 3.29, 95% CI 1.07-10.17, P = .04). Conclusions: Length, size, and types of DES may be more important than clinical factors in intracoronary thrombus formation after DES implantations.

AB - Background: Intracoronary thrombus formation after drug-eluting stent (DES) implantation is not sufficiently evaluated. Methods: Optical coherence tomography (OCT) was performed in 226 patients (total DES n = 244, sirolimus-eluting stent [SES] n = 95, paclitaxel-eluting stent [PES] n = 62, zotarolimus-eluting stent [ZES] n = 87) after implantation (mean 11 months, range 3-66 months). Using OCT, we investigated the incidence and determinants of intracoronary thrombus. Results: Intracoronary thrombus was detected in 35 (14%) cases (27 SES [28%], 7 PES [11%], and 1 ZES [1%], P < .001) and was associated with longer stent, smaller stent diameter, and stents at bifurcation lesions. More uncovered stent struts (26 ± 23 vs 8 ± 17, P < .001) and malapposed stent struts (6 ± 14 vs 2 ± 6, P < .001) were also associated with intracoronary thrombus. Multiple logistic regression analysis found the following determinants of intracoronary thrombus: stent length ≥28 mm (odds ratio [OR] 7.31, 95% CI 1.79-29.86, P = .01), stent diameter <3.0 mm (OR 4.38, 95% CI 1.38-13.97, P = .01), and ≥8 uncovered struts in each stent (OR 3.29, 95% CI 1.07-10.17, P = .04). Conclusions: Length, size, and types of DES may be more important than clinical factors in intracoronary thrombus formation after DES implantations.

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