Intracoronary thrombus formation after drug-eluting stents implantation: Optical coherence tomographic study

Jung Sun Kim, Myeong Ki Hong, Chunyu Fan, Tae Hoon Kim, Jae Min Shim, Sang Min Park, Young Guk Ko, Donghoon Choi, Yangsoo Jang

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Background: Intracoronary thrombus formation after drug-eluting stent (DES) implantation is not sufficiently evaluated. Methods: Optical coherence tomography (OCT) was performed in 226 patients (total DES n = 244, sirolimus-eluting stent [SES] n = 95, paclitaxel-eluting stent [PES] n = 62, zotarolimus-eluting stent [ZES] n = 87) after implantation (mean 11 months, range 3-66 months). Using OCT, we investigated the incidence and determinants of intracoronary thrombus. Results: Intracoronary thrombus was detected in 35 (14%) cases (27 SES [28%], 7 PES [11%], and 1 ZES [1%], P < .001) and was associated with longer stent, smaller stent diameter, and stents at bifurcation lesions. More uncovered stent struts (26 ± 23 vs 8 ± 17, P < .001) and malapposed stent struts (6 ± 14 vs 2 ± 6, P < .001) were also associated with intracoronary thrombus. Multiple logistic regression analysis found the following determinants of intracoronary thrombus: stent length ≥28 mm (odds ratio [OR] 7.31, 95% CI 1.79-29.86, P = .01), stent diameter <3.0 mm (OR 4.38, 95% CI 1.38-13.97, P = .01), and ≥8 uncovered struts in each stent (OR 3.29, 95% CI 1.07-10.17, P = .04). Conclusions: Length, size, and types of DES may be more important than clinical factors in intracoronary thrombus formation after DES implantations.

Original languageEnglish
Pages (from-to)278-283
Number of pages6
JournalAmerican heart journal
Volume159
Issue number2
DOIs
Publication statusPublished - 2010 Feb

Bibliographical note

Funding Information:
This study was partly supported by a grant of the Korea Health care technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea (no. A085012 and A000385 ), a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (no. A085136 ), and the Cardiovascular Research Center, Seoul, Korea .

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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