Abstract
Background: Intracoronary thrombus formation after drug-eluting stent (DES) implantation is not sufficiently evaluated. Methods: Optical coherence tomography (OCT) was performed in 226 patients (total DES n = 244, sirolimus-eluting stent [SES] n = 95, paclitaxel-eluting stent [PES] n = 62, zotarolimus-eluting stent [ZES] n = 87) after implantation (mean 11 months, range 3-66 months). Using OCT, we investigated the incidence and determinants of intracoronary thrombus. Results: Intracoronary thrombus was detected in 35 (14%) cases (27 SES [28%], 7 PES [11%], and 1 ZES [1%], P < .001) and was associated with longer stent, smaller stent diameter, and stents at bifurcation lesions. More uncovered stent struts (26 ± 23 vs 8 ± 17, P < .001) and malapposed stent struts (6 ± 14 vs 2 ± 6, P < .001) were also associated with intracoronary thrombus. Multiple logistic regression analysis found the following determinants of intracoronary thrombus: stent length ≥28 mm (odds ratio [OR] 7.31, 95% CI 1.79-29.86, P = .01), stent diameter <3.0 mm (OR 4.38, 95% CI 1.38-13.97, P = .01), and ≥8 uncovered struts in each stent (OR 3.29, 95% CI 1.07-10.17, P = .04). Conclusions: Length, size, and types of DES may be more important than clinical factors in intracoronary thrombus formation after DES implantations.
| Original language | English |
|---|---|
| Pages (from-to) | 278-283 |
| Number of pages | 6 |
| Journal | American heart journal |
| Volume | 159 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2010 Feb 1 |
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All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine
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Intracoronary thrombus formation after drug-eluting stents implantation : Optical coherence tomographic study. / Kim, Jung Sun; Hong, Myeong Ki; Fan, Chunyu; Kim, Tae Hoon; Shim, Jae Min; Park, Sang Min; Ko, Young Guk; Choi, Donghoon; Jang, Yangsoo.
In: American heart journal, Vol. 159, No. 2, 01.02.2010, p. 278-283.Research output: Contribution to journal › Article
TY - JOUR
T1 - Intracoronary thrombus formation after drug-eluting stents implantation
T2 - Optical coherence tomographic study
AU - Kim, Jung Sun
AU - Hong, Myeong Ki
AU - Fan, Chunyu
AU - Kim, Tae Hoon
AU - Shim, Jae Min
AU - Park, Sang Min
AU - Ko, Young Guk
AU - Choi, Donghoon
AU - Jang, Yangsoo
PY - 2010/2/1
Y1 - 2010/2/1
N2 - Background: Intracoronary thrombus formation after drug-eluting stent (DES) implantation is not sufficiently evaluated. Methods: Optical coherence tomography (OCT) was performed in 226 patients (total DES n = 244, sirolimus-eluting stent [SES] n = 95, paclitaxel-eluting stent [PES] n = 62, zotarolimus-eluting stent [ZES] n = 87) after implantation (mean 11 months, range 3-66 months). Using OCT, we investigated the incidence and determinants of intracoronary thrombus. Results: Intracoronary thrombus was detected in 35 (14%) cases (27 SES [28%], 7 PES [11%], and 1 ZES [1%], P < .001) and was associated with longer stent, smaller stent diameter, and stents at bifurcation lesions. More uncovered stent struts (26 ± 23 vs 8 ± 17, P < .001) and malapposed stent struts (6 ± 14 vs 2 ± 6, P < .001) were also associated with intracoronary thrombus. Multiple logistic regression analysis found the following determinants of intracoronary thrombus: stent length ≥28 mm (odds ratio [OR] 7.31, 95% CI 1.79-29.86, P = .01), stent diameter <3.0 mm (OR 4.38, 95% CI 1.38-13.97, P = .01), and ≥8 uncovered struts in each stent (OR 3.29, 95% CI 1.07-10.17, P = .04). Conclusions: Length, size, and types of DES may be more important than clinical factors in intracoronary thrombus formation after DES implantations.
AB - Background: Intracoronary thrombus formation after drug-eluting stent (DES) implantation is not sufficiently evaluated. Methods: Optical coherence tomography (OCT) was performed in 226 patients (total DES n = 244, sirolimus-eluting stent [SES] n = 95, paclitaxel-eluting stent [PES] n = 62, zotarolimus-eluting stent [ZES] n = 87) after implantation (mean 11 months, range 3-66 months). Using OCT, we investigated the incidence and determinants of intracoronary thrombus. Results: Intracoronary thrombus was detected in 35 (14%) cases (27 SES [28%], 7 PES [11%], and 1 ZES [1%], P < .001) and was associated with longer stent, smaller stent diameter, and stents at bifurcation lesions. More uncovered stent struts (26 ± 23 vs 8 ± 17, P < .001) and malapposed stent struts (6 ± 14 vs 2 ± 6, P < .001) were also associated with intracoronary thrombus. Multiple logistic regression analysis found the following determinants of intracoronary thrombus: stent length ≥28 mm (odds ratio [OR] 7.31, 95% CI 1.79-29.86, P = .01), stent diameter <3.0 mm (OR 4.38, 95% CI 1.38-13.97, P = .01), and ≥8 uncovered struts in each stent (OR 3.29, 95% CI 1.07-10.17, P = .04). Conclusions: Length, size, and types of DES may be more important than clinical factors in intracoronary thrombus formation after DES implantations.
UR - http://www.scopus.com/inward/record.url?scp=75249103029&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=75249103029&partnerID=8YFLogxK
U2 - 10.1016/j.ahj.2009.11.029
DO - 10.1016/j.ahj.2009.11.029
M3 - Article
C2 - 20152227
AN - SCOPUS:75249103029
VL - 159
SP - 278
EP - 283
JO - American Heart Journal
JF - American Heart Journal
SN - 0002-8703
IS - 2
ER -