Abstract
To evaluate the potential benefit of intraocular pressure (IOP) reduction in normal-tension glaucoma (NTG) patients in South Korea. A retrospective, multi-center analysis of Korean NTG patients with 5-years follow-up, typical glaucomatous optic disc and/or visual field changes and no recorded IOP >21 mmHg. Progression was identified by Advanced Glaucoma Intervention Study visual field scoring. There were 90 (42%) progressed patients and 127 (58%) stable patients included in the study. Mean IOP measured higher in the progressed (14.3 ± 2.2 mmHg) than stable patients (14.0 ± 1.9 mmHg), but was not statistically different between the groups (P = 0.29). The mean IOP that best discriminated stable patients was ≥15 mmHg, but no statistical difference existed in the numbers of progressed versus stable patients at ≥15 mmHg compared to >15 mmHg (P = 0.07). Multivariate regression analysis showed that the baseline number of glaucoma medicines and visual field as well as mean, peak and fluctuation of IOP were significant risk factors for glaucomatous progression (P < 0.01). This study suggests that in Korean NTG patients, despite relatively similar IOPs between progressed and stable patients, and based on multivariate regression analysis, IOP may be a risk factor for glaucomatous progression.
| Original language | English |
|---|---|
| Pages (from-to) | 355-361 |
| Number of pages | 7 |
| Journal | International Ophthalmology |
| Volume | 31 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2011 Oct 1 |
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All Science Journal Classification (ASJC) codes
- Ophthalmology
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Intraocular pressure reduction in normal-tension glaucoma patients in South Korea. / Ma, Kyoung Tak; Kim, Chan Yun; Seong, Gong Je; Lee, Seung Hyuck; Park, Jong Woon; Ha, Seung Joo; Cho, Byung Joo; Stewart, Jeanette A.; Kristoffersen, Michael S.; Nelson, Lindsay A.; Stewart, William C.
In: International Ophthalmology, Vol. 31, No. 5, 01.10.2011, p. 355-361.Research output: Contribution to journal › Article
TY - JOUR
T1 - Intraocular pressure reduction in normal-tension glaucoma patients in South Korea
AU - Ma, Kyoung Tak
AU - Kim, Chan Yun
AU - Seong, Gong Je
AU - Lee, Seung Hyuck
AU - Park, Jong Woon
AU - Ha, Seung Joo
AU - Cho, Byung Joo
AU - Stewart, Jeanette A.
AU - Kristoffersen, Michael S.
AU - Nelson, Lindsay A.
AU - Stewart, William C.
PY - 2011/10/1
Y1 - 2011/10/1
N2 - To evaluate the potential benefit of intraocular pressure (IOP) reduction in normal-tension glaucoma (NTG) patients in South Korea. A retrospective, multi-center analysis of Korean NTG patients with 5-years follow-up, typical glaucomatous optic disc and/or visual field changes and no recorded IOP >21 mmHg. Progression was identified by Advanced Glaucoma Intervention Study visual field scoring. There were 90 (42%) progressed patients and 127 (58%) stable patients included in the study. Mean IOP measured higher in the progressed (14.3 ± 2.2 mmHg) than stable patients (14.0 ± 1.9 mmHg), but was not statistically different between the groups (P = 0.29). The mean IOP that best discriminated stable patients was ≥15 mmHg, but no statistical difference existed in the numbers of progressed versus stable patients at ≥15 mmHg compared to >15 mmHg (P = 0.07). Multivariate regression analysis showed that the baseline number of glaucoma medicines and visual field as well as mean, peak and fluctuation of IOP were significant risk factors for glaucomatous progression (P < 0.01). This study suggests that in Korean NTG patients, despite relatively similar IOPs between progressed and stable patients, and based on multivariate regression analysis, IOP may be a risk factor for glaucomatous progression.
AB - To evaluate the potential benefit of intraocular pressure (IOP) reduction in normal-tension glaucoma (NTG) patients in South Korea. A retrospective, multi-center analysis of Korean NTG patients with 5-years follow-up, typical glaucomatous optic disc and/or visual field changes and no recorded IOP >21 mmHg. Progression was identified by Advanced Glaucoma Intervention Study visual field scoring. There were 90 (42%) progressed patients and 127 (58%) stable patients included in the study. Mean IOP measured higher in the progressed (14.3 ± 2.2 mmHg) than stable patients (14.0 ± 1.9 mmHg), but was not statistically different between the groups (P = 0.29). The mean IOP that best discriminated stable patients was ≥15 mmHg, but no statistical difference existed in the numbers of progressed versus stable patients at ≥15 mmHg compared to >15 mmHg (P = 0.07). Multivariate regression analysis showed that the baseline number of glaucoma medicines and visual field as well as mean, peak and fluctuation of IOP were significant risk factors for glaucomatous progression (P < 0.01). This study suggests that in Korean NTG patients, despite relatively similar IOPs between progressed and stable patients, and based on multivariate regression analysis, IOP may be a risk factor for glaucomatous progression.
UR - http://www.scopus.com/inward/record.url?scp=82955164378&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=82955164378&partnerID=8YFLogxK
U2 - 10.1007/s10792-011-9463-7
DO - 10.1007/s10792-011-9463-7
M3 - Article
C2 - 21901560
AN - SCOPUS:82955164378
VL - 31
SP - 355
EP - 361
JO - International Ophthalmology
JF - International Ophthalmology
SN - 0165-5701
IS - 5
ER -