Intratympanic dexamethasone is an effective method as a salvage treatment in refractory sudden hearing loss

InSeok Moon, Jong Dae Lee, Jin Kim, Sung Jong Hong, Won Sang Lee

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Objectives: This study aimed to investigate the therapeutic efficacy of intratympanic dexamethasone (ITD) as a salvage treatment in sudden hearing loss (SHL) patients who had no response to initial systemic combination steroid therapy. Patients and Methods: From May 2007 to June 2010, 415 SHL patients visited 3 tertiary referral centers within 7 days of disease onset. They were all treated with an identical protocol, a 10-day scheduled hospitalization and oral steroid treatment. Of these, 151 patients were totally unresponsive 2 weeks after treatment initiation according to Siegel's criteria. We divided these 151 refractory patients into 3 groups: those receiving no further treatment (control group, n = 59), those receiving one more 10-day cycle of oral steroids (systemic reapplication group, n = 26), and those receiving ITD therapy (ITD group, n = 66). Final assessment of hearing was conducted approximately 3 months after the onset of SHL. Hearing improvement was defined as demonstrating "any" improvement according to Siegel's criteria. Results: The initial average hearing thresholds of all groups were similar. Overall hearing improvement was observed in 10 of 59 patients in the control group, in 4 of 26 in the systemic reapplication group, and in 32 of 66 in the ITD group. No serious complications were observed. Analyzing by frequency, paradoxically, hearing of the low and mid frequencies was more significantly improved than high frequencies in the ITD group. Conclusion: Intratympanic dexamethasone administration after failure of an initial treatment is effective, and this should be used as a salvage treatment in cases of refractory SHL.

Original languageEnglish
Pages (from-to)1432-1436
Number of pages5
JournalOtology and Neurotology
Volume32
Issue number9
DOIs
Publication statusPublished - 2011 Dec 1

Fingerprint

Sudden Hearing Loss
Salvage Therapy
Dexamethasone
Hearing
Steroids
Therapeutics
Control Groups
Treatment Failure
Tertiary Care Centers
Hospitalization

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology
  • Sensory Systems
  • Clinical Neurology

Cite this

Moon, InSeok ; Lee, Jong Dae ; Kim, Jin ; Hong, Sung Jong ; Lee, Won Sang. / Intratympanic dexamethasone is an effective method as a salvage treatment in refractory sudden hearing loss. In: Otology and Neurotology. 2011 ; Vol. 32, No. 9. pp. 1432-1436.
@article{e137c091817d4e04a034451618d87327,
title = "Intratympanic dexamethasone is an effective method as a salvage treatment in refractory sudden hearing loss",
abstract = "Objectives: This study aimed to investigate the therapeutic efficacy of intratympanic dexamethasone (ITD) as a salvage treatment in sudden hearing loss (SHL) patients who had no response to initial systemic combination steroid therapy. Patients and Methods: From May 2007 to June 2010, 415 SHL patients visited 3 tertiary referral centers within 7 days of disease onset. They were all treated with an identical protocol, a 10-day scheduled hospitalization and oral steroid treatment. Of these, 151 patients were totally unresponsive 2 weeks after treatment initiation according to Siegel's criteria. We divided these 151 refractory patients into 3 groups: those receiving no further treatment (control group, n = 59), those receiving one more 10-day cycle of oral steroids (systemic reapplication group, n = 26), and those receiving ITD therapy (ITD group, n = 66). Final assessment of hearing was conducted approximately 3 months after the onset of SHL. Hearing improvement was defined as demonstrating {"}any{"} improvement according to Siegel's criteria. Results: The initial average hearing thresholds of all groups were similar. Overall hearing improvement was observed in 10 of 59 patients in the control group, in 4 of 26 in the systemic reapplication group, and in 32 of 66 in the ITD group. No serious complications were observed. Analyzing by frequency, paradoxically, hearing of the low and mid frequencies was more significantly improved than high frequencies in the ITD group. Conclusion: Intratympanic dexamethasone administration after failure of an initial treatment is effective, and this should be used as a salvage treatment in cases of refractory SHL.",
author = "InSeok Moon and Lee, {Jong Dae} and Jin Kim and Hong, {Sung Jong} and Lee, {Won Sang}",
year = "2011",
month = "12",
day = "1",
doi = "10.1097/MAO.0b013e318238fc43",
language = "English",
volume = "32",
pages = "1432--1436",
journal = "Otology and Neurotology",
issn = "1531-7129",
publisher = "Lippincott Williams and Wilkins",
number = "9",

}

Intratympanic dexamethasone is an effective method as a salvage treatment in refractory sudden hearing loss. / Moon, InSeok; Lee, Jong Dae; Kim, Jin; Hong, Sung Jong; Lee, Won Sang.

In: Otology and Neurotology, Vol. 32, No. 9, 01.12.2011, p. 1432-1436.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Intratympanic dexamethasone is an effective method as a salvage treatment in refractory sudden hearing loss

AU - Moon, InSeok

AU - Lee, Jong Dae

AU - Kim, Jin

AU - Hong, Sung Jong

AU - Lee, Won Sang

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Objectives: This study aimed to investigate the therapeutic efficacy of intratympanic dexamethasone (ITD) as a salvage treatment in sudden hearing loss (SHL) patients who had no response to initial systemic combination steroid therapy. Patients and Methods: From May 2007 to June 2010, 415 SHL patients visited 3 tertiary referral centers within 7 days of disease onset. They were all treated with an identical protocol, a 10-day scheduled hospitalization and oral steroid treatment. Of these, 151 patients were totally unresponsive 2 weeks after treatment initiation according to Siegel's criteria. We divided these 151 refractory patients into 3 groups: those receiving no further treatment (control group, n = 59), those receiving one more 10-day cycle of oral steroids (systemic reapplication group, n = 26), and those receiving ITD therapy (ITD group, n = 66). Final assessment of hearing was conducted approximately 3 months after the onset of SHL. Hearing improvement was defined as demonstrating "any" improvement according to Siegel's criteria. Results: The initial average hearing thresholds of all groups were similar. Overall hearing improvement was observed in 10 of 59 patients in the control group, in 4 of 26 in the systemic reapplication group, and in 32 of 66 in the ITD group. No serious complications were observed. Analyzing by frequency, paradoxically, hearing of the low and mid frequencies was more significantly improved than high frequencies in the ITD group. Conclusion: Intratympanic dexamethasone administration after failure of an initial treatment is effective, and this should be used as a salvage treatment in cases of refractory SHL.

AB - Objectives: This study aimed to investigate the therapeutic efficacy of intratympanic dexamethasone (ITD) as a salvage treatment in sudden hearing loss (SHL) patients who had no response to initial systemic combination steroid therapy. Patients and Methods: From May 2007 to June 2010, 415 SHL patients visited 3 tertiary referral centers within 7 days of disease onset. They were all treated with an identical protocol, a 10-day scheduled hospitalization and oral steroid treatment. Of these, 151 patients were totally unresponsive 2 weeks after treatment initiation according to Siegel's criteria. We divided these 151 refractory patients into 3 groups: those receiving no further treatment (control group, n = 59), those receiving one more 10-day cycle of oral steroids (systemic reapplication group, n = 26), and those receiving ITD therapy (ITD group, n = 66). Final assessment of hearing was conducted approximately 3 months after the onset of SHL. Hearing improvement was defined as demonstrating "any" improvement according to Siegel's criteria. Results: The initial average hearing thresholds of all groups were similar. Overall hearing improvement was observed in 10 of 59 patients in the control group, in 4 of 26 in the systemic reapplication group, and in 32 of 66 in the ITD group. No serious complications were observed. Analyzing by frequency, paradoxically, hearing of the low and mid frequencies was more significantly improved than high frequencies in the ITD group. Conclusion: Intratympanic dexamethasone administration after failure of an initial treatment is effective, and this should be used as a salvage treatment in cases of refractory SHL.

UR - http://www.scopus.com/inward/record.url?scp=81855228606&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=81855228606&partnerID=8YFLogxK

U2 - 10.1097/MAO.0b013e318238fc43

DO - 10.1097/MAO.0b013e318238fc43

M3 - Article

VL - 32

SP - 1432

EP - 1436

JO - Otology and Neurotology

JF - Otology and Neurotology

SN - 1531-7129

IS - 9

ER -