Intravascular ultrasound analysis of beta radiation therapy for diffuse in-stent restenosis to inhibit intimal hyperplasia

Myeong Ki Hong, Seong Wook Park, Dae Hyuk Moon, Seung Jun Oh, Cheol Whan Lee, Kyoung Suk Rhee, Fucheng Sun, Jong Min Song, Duk Hyun Kang, Jae Kwan Song, Jae Joong Kim, Seung Jung Park

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Abstract

We evaluated the efficacy of β-radiation therapy (188Re-MAG3) to inhibit intimal hyperplasia (IH) in diffuse in-stent restenosis by intravascular ultrasound (IVUS) analysis in 50 patients. Nine patients who did not agree with radiation therapy, and therefore underwent rotational atherectomy and balloon angioplasty for diffuse in-stent restenosis in the same study period, were selected for control groups. Serial IVUS comparisons were available in 44 of 50 patients with radiation therapy and 7 of 9 control patients. At 6-month follow-up, there was less significant increase of IH area in patients with radiation therapy than in control patients (Δ IH area = 0.1±0.8 mm2 vs. 2.6±1.8 mm2, P>0.001 in mean values, and 0.6±1.4 mm2 vs. 2.9±2.1 mm2, P = 0.026 in values of follow-up lesion site, respectively). In conclusion, β-radiation therapy might be an effective treatment modality to inhibit intimal hyperplasia in patients with diffuse in-stent restenosis.

Original languageEnglish
Pages (from-to)169-173
Number of pages5
JournalCatheterization and Cardiovascular Interventions
Volume54
Issue number2
DOIs
Publication statusPublished - 2001 Oct 22

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All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Hong, M. K., Park, S. W., Moon, D. H., Oh, S. J., Lee, C. W., Rhee, K. S., Sun, F., Song, J. M., Kang, D. H., Song, J. K., Kim, J. J., & Park, S. J. (2001). Intravascular ultrasound analysis of beta radiation therapy for diffuse in-stent restenosis to inhibit intimal hyperplasia. Catheterization and Cardiovascular Interventions, 54(2), 169-173. https://doi.org/10.1002/ccd.1261