The effects of β-radiation therapy on nonstented adjacent segments in in-stent restenosis have not been sufficiently evaluated. β-radiation therapy for in-stent restenosis was performed with a 188Re-MAG3-filled balloon. We evaluated the effects of β-radiation therapy on nonstented adjacent segments in in-stent restenosis by intravascular ultrasound (IVUS) analysis in 50 patients who received radiation therapy vs. 9 control patients. The changes (Δ = follow-up - postintervention) of the external elastic membrane (EEM), the lumen, and other IVUS variables were compared between the segments that received radiation therapy and the control segments. The significant differences between the two groups were as follows: Δ EEM area was 0.3 mm2 in the radiation vs. -1.0 mm2 in the control (P = 0.005) and Δ lumen area was 0.2 mm2 vs. -1.3 mm2, respectively (P < 0.001). In conclusion, compared with the changes of vessel shrinkage in the control group, significant vessel enlargement occurred in the nonstented adjacent segments that received radiation therapy.
All Science Journal Classification (ASJC) codes
- Radiology Nuclear Medicine and imaging
- Cardiology and Cardiovascular Medicine