Intravascular ultrasound analysis of nonstented adjacent segments in diffuse in-stent restenosis treated with radiation therapy with a Rhenium-188-filled balloon

Myeong Ki Hong, Seong Wook Park, Dae Hyuk Moon, Seung Jun Oh, Cheol Whan Lee, Young Hak Kim, Jae Whan Lee, Jong Min Song, Duk Hyun Kang, Jae Kwan Song, Jae Joong Kim, Seung Jung Park

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Abstract

The effects of β-radiation therapy on nonstented adjacent segments in in-stent restenosis have not been sufficiently evaluated. β-radiation therapy for in-stent restenosis was performed with a 188Re-MAG3-filled balloon. We evaluated the effects of β-radiation therapy on nonstented adjacent segments in in-stent restenosis by intravascular ultrasound (IVUS) analysis in 50 patients who received radiation therapy vs. 9 control patients. The changes (Δ = follow-up - postintervention) of the external elastic membrane (EEM), the lumen, and other IVUS variables were compared between the segments that received radiation therapy and the control segments. The significant differences between the two groups were as follows: Δ EEM area was 0.3 mm2 in the radiation vs. -1.0 mm2 in the control (P = 0.005) and Δ lumen area was 0.2 mm2 vs. -1.3 mm2, respectively (P < 0.001). In conclusion, compared with the changes of vessel shrinkage in the control group, significant vessel enlargement occurred in the nonstented adjacent segments that received radiation therapy.

Original languageEnglish
Pages (from-to)428-433
Number of pages6
JournalCatheterization and Cardiovascular Interventions
Volume58
Issue number4
DOIs
Publication statusPublished - 2003 Apr 1

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All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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