Intravascular ultrasound predictors of angiographic restenosis after sirolimus-eluting stent implantation

Myeong Ki Hong, Gary S. Mintz, Cheol Whan Lee, Duk Woo Park, Bong Ryong Choi, Kyoung Ha Park, Young Hak Kim, Sang Sig Cheong, Jae Kwan Song, Jae Joong Kim, Seong Wook Park, Seung Jung Park

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Abstract

Aims: In many countries, drug-eluting stent implantation is the dominant interventional strategy. We evaluated the clinical, angiographic, procedural, and intravascular ultrasound (IVUS) predictors of angiographic restenosis after sirolimus-eluting stent (SES) implantation. Methods and results: SES implantation was successfully performed in 550 patients with 670 native coronary lesions. Six-month follow-up angiography was performed in 449 patients (81.6%) with 543 lesions (81.1%). Clinical, angiographic, procedural, and IVUS predictors of restenosis were determined. Using multivariable logistic regression analysis, the only independent predictors of angiographic restenosis were post-procedural final minimum stent area by IVUS [odds ratio (OR)=0.586, 95% confidence interval (CI) 0.387-0.888, P=0.012] and IVUS-measured stent length (OR=1.029, 95% CI 1.002-1.056, P=0.035). Final minimum stent area by IVUS and IVUS-measured stent length that best separated restenosis from non-restenosis were 5.5 mm2 and 40 mm, respectively. Lesions with final minimum stent area <5.5 mm2 and stent length >40 mm had the highest rate of angiographic restenosis [17.7% (11/62)], P<0.001 compared with other groups. Conclusion: Independent predictors of angiographic restenosis after SES implantation were post-procedural final minimum stent area by IVUS and IVUS-measured stent length. The angiographic restenosis rate was highest in lesions with stent area <5.5 mm2 and stent length >40 mm.

Original languageEnglish
Pages (from-to)1305-1310
Number of pages6
JournalEuropean heart journal
Volume27
Issue number11
DOIs
Publication statusPublished - 2006 Jun

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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    Hong, M. K., Mintz, G. S., Lee, C. W., Park, D. W., Choi, B. R., Park, K. H., Kim, Y. H., Cheong, S. S., Song, J. K., Kim, J. J., Park, S. W., & Park, S. J. (2006). Intravascular ultrasound predictors of angiographic restenosis after sirolimus-eluting stent implantation. European heart journal, 27(11), 1305-1310. https://doi.org/10.1093/eurheartj/ehi882