Intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) antibody via Tower Microneedle

Chang Yeol Lee, Yonghao Ma, Yong Sung You, Hyoung Eun Kim, Young Dook Byeon, Hyungil Jung

Research output: Contribution to journalArticle

Abstract

Tower Microneedle was developed with minimal ocular tissue damages even reflux, while no study was reported with intravitreal injection of ophthalmic drug via Tower Microneedle into the eye. Intravitreal injection of anti-vascular endothelial growth factor antibodies via the Tower Microneedle or a 30-G hypodermic needle was performed 1 week after argon laser irradiation into the retina of the mouse models. Less bleb formation was occurred with Tower Microneedle than 30-G hypodermic needle, while both needles led to comparable degrees of anti-angiogenesis in the retina after intravitreal injection of anti-vascular endothelial growth factor antibodies over 100 ng/μL concentration. Conclusively, the Tower Microneedle can deliver anti-vascular endothelial growth factor antibody into the posterior segment of the eye with minimal bleb formation after intravitreal injection.

Original languageEnglish
Pages (from-to)232-238
Number of pages7
JournalBiochip Journal
Volume9
Issue number3
DOIs
Publication statusPublished - 2015 Sep 28

Fingerprint

Intravitreal Injections
Antibodies
Towers
Vascular Endothelial Growth Factor A
Needles
Blister
Retina
Posterior Eye Segment
Argon
Argon lasers
Laser beam effects
Lasers
Intercellular Signaling Peptides and Proteins
Tissue
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Electrical and Electronic Engineering

Cite this

Lee, Chang Yeol ; Ma, Yonghao ; You, Yong Sung ; Kim, Hyoung Eun ; Byeon, Young Dook ; Jung, Hyungil. / Intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) antibody via Tower Microneedle. In: Biochip Journal. 2015 ; Vol. 9, No. 3. pp. 232-238.
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Intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) antibody via Tower Microneedle. / Lee, Chang Yeol; Ma, Yonghao; You, Yong Sung; Kim, Hyoung Eun; Byeon, Young Dook; Jung, Hyungil.

In: Biochip Journal, Vol. 9, No. 3, 28.09.2015, p. 232-238.

Research output: Contribution to journalArticle

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