Viperin is an interferon (IFN)-inducible multifunctional protein. Recent evidence from high-throughput analyses indicates that most IFN-inducible proteins, including viperin, are intrinsically expressed in specific tissues; however, the respective intrinsic functions are unknown. Here we show that the intrinsic expression of viperin regulates adipose tissue thermogenesis, which is known to counter metabolic disease and contribute to the febrile response to pathogen invasion. Viperin knockout mice exhibit increased heat production, resulting in a reduction of fat mass, improvement of high-fat diet (HFD)-induced glucose tolerance, and enhancement of cold tolerance. These thermogenic phenotypes are attributed to an adipocyte-autonomous mechanism that regulates fatty acid β-oxidation. Under an HFD, viperin expression is increased, and its function is enhanced. Our findings reveal the intrinsic function of viperin as a novel mechanism regulating thermogenesis in adipose tissues, suggesting that viperin represents a molecular target for thermoregulation in clinical contexts.
|Number of pages||10|
|Journal||Proceedings of the National Academy of Sciences of the United States of America|
|Publication status||Published - 2019 Aug 27|
Bibliographical noteFunding Information:
ACKNOWLEDGMENTS. This study was supported by grants from the National Research Foundation of Korea funded by the Ministry of Science, ICT, and Future Planning (NRF-2016R1A2B4014630, NRF-2014R1A4A1008625, and Korea Mouse Phenotyping Project 2013M3A9D5072550); a faculty research grant from Yonsei University College of Medicine for 2018 (6-2018-0168, to J.-Y.S.); and the Brain Korea 21 PLUS Project for Medical Science, Yonsei University.
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