Introduction of the reliable estimation of atopic dermatitis in childhood

Novel, diagnostic criteria for childhood atopic dermatitis

The Korean Atopic Dermatitis Association's Atopic Dermatitis Criteria Group

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Purpose: Questionnaire-based diagnostic criteria for atopic dermatitis (AD) have been proposed to detect the major group of AD with flexural dermatitis. We aimed to develop novel, questionnaire-based diagnostic criteria for childhood AD, which can detect more comprehensive AD including non-flexural type. Methods: The draft version of questionnaire to detect childhood AD was prepared to be used for preliminary hospital- (n=1,756) and community-based (n=1,320) surveys. From analysis, the Reliable Estimation of Atopic dermatitis of ChildHood (REACH) was derived and verified in derivation (n=129) and validation (n=191) sets by community-based surveys. Results: The REACH consists of 11 questions including 2 major and 9 minor criteria. AD is diagnosed as the major group of 'eczema on the antecubital or popliteal fossa' to fulfill the 2 major criteria (2M), and the minor group of 'eczema on the non-antecubital or popliteal fossa' to fulfill the 1 major plus 4 or more minor criteria (1M+4m). In the validation set, the overall 1-year AD prevalence by the REACH was estimated as 12.3% (95% CI, 10.5%-14.2%), and the REACH showed a sensitivity of 75.2%, a specificity of 96.1%, and an error rate of 6.4%. The REACH demonstrated better diagnostic performance than the ISAAC in terms of the number of misclassification (10.0%). Conclusions: We propose the REACH as new full, questionnaire-based diagnostic criteria for childhood AD in epidemiological surveys. Further studies are warranted to validate the REACH in different populations or countries in the context of large-scale, epidemiological surveys.

Original languageEnglish
Pages (from-to)230-238
Number of pages9
JournalAllergy, Asthma and Immunology Research
Volume8
Issue number3
DOIs
Publication statusPublished - 2016 Jan 1

Fingerprint

Atopic Dermatitis
Eczema
Surveys and Questionnaires
Dermatitis

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine

Cite this

The Korean Atopic Dermatitis Association's Atopic Dermatitis Criteria Group. / Introduction of the reliable estimation of atopic dermatitis in childhood : Novel, diagnostic criteria for childhood atopic dermatitis. In: Allergy, Asthma and Immunology Research. 2016 ; Vol. 8, No. 3. pp. 230-238.
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title = "Introduction of the reliable estimation of atopic dermatitis in childhood: Novel, diagnostic criteria for childhood atopic dermatitis",
abstract = "Purpose: Questionnaire-based diagnostic criteria for atopic dermatitis (AD) have been proposed to detect the major group of AD with flexural dermatitis. We aimed to develop novel, questionnaire-based diagnostic criteria for childhood AD, which can detect more comprehensive AD including non-flexural type. Methods: The draft version of questionnaire to detect childhood AD was prepared to be used for preliminary hospital- (n=1,756) and community-based (n=1,320) surveys. From analysis, the Reliable Estimation of Atopic dermatitis of ChildHood (REACH) was derived and verified in derivation (n=129) and validation (n=191) sets by community-based surveys. Results: The REACH consists of 11 questions including 2 major and 9 minor criteria. AD is diagnosed as the major group of 'eczema on the antecubital or popliteal fossa' to fulfill the 2 major criteria (2M), and the minor group of 'eczema on the non-antecubital or popliteal fossa' to fulfill the 1 major plus 4 or more minor criteria (1M+4m). In the validation set, the overall 1-year AD prevalence by the REACH was estimated as 12.3{\%} (95{\%} CI, 10.5{\%}-14.2{\%}), and the REACH showed a sensitivity of 75.2{\%}, a specificity of 96.1{\%}, and an error rate of 6.4{\%}. The REACH demonstrated better diagnostic performance than the ISAAC in terms of the number of misclassification (10.0{\%}). Conclusions: We propose the REACH as new full, questionnaire-based diagnostic criteria for childhood AD in epidemiological surveys. Further studies are warranted to validate the REACH in different populations or countries in the context of large-scale, epidemiological surveys.",
author = "{The Korean Atopic Dermatitis Association's Atopic Dermatitis Criteria Group} and Lee, {Seung Chul} and Bae, {Jung Min} and Lee, {Ho June} and Kim, {Hyun Jung} and Kim, {Byung Soo} and Kapsok Li and Cho, {Jae We} and Park, {Chang Ook} and Cho, {Sang Hyun} and Kwanghoon Lee and Kim, {Do Won} and Park, {Chun Wook} and Kim, {Kyu Han}",
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Introduction of the reliable estimation of atopic dermatitis in childhood : Novel, diagnostic criteria for childhood atopic dermatitis. / The Korean Atopic Dermatitis Association's Atopic Dermatitis Criteria Group.

In: Allergy, Asthma and Immunology Research, Vol. 8, No. 3, 01.01.2016, p. 230-238.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Introduction of the reliable estimation of atopic dermatitis in childhood

T2 - Novel, diagnostic criteria for childhood atopic dermatitis

AU - The Korean Atopic Dermatitis Association's Atopic Dermatitis Criteria Group

AU - Lee, Seung Chul

AU - Bae, Jung Min

AU - Lee, Ho June

AU - Kim, Hyun Jung

AU - Kim, Byung Soo

AU - Li, Kapsok

AU - Cho, Jae We

AU - Park, Chang Ook

AU - Cho, Sang Hyun

AU - Lee, Kwanghoon

AU - Kim, Do Won

AU - Park, Chun Wook

AU - Kim, Kyu Han

PY - 2016/1/1

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N2 - Purpose: Questionnaire-based diagnostic criteria for atopic dermatitis (AD) have been proposed to detect the major group of AD with flexural dermatitis. We aimed to develop novel, questionnaire-based diagnostic criteria for childhood AD, which can detect more comprehensive AD including non-flexural type. Methods: The draft version of questionnaire to detect childhood AD was prepared to be used for preliminary hospital- (n=1,756) and community-based (n=1,320) surveys. From analysis, the Reliable Estimation of Atopic dermatitis of ChildHood (REACH) was derived and verified in derivation (n=129) and validation (n=191) sets by community-based surveys. Results: The REACH consists of 11 questions including 2 major and 9 minor criteria. AD is diagnosed as the major group of 'eczema on the antecubital or popliteal fossa' to fulfill the 2 major criteria (2M), and the minor group of 'eczema on the non-antecubital or popliteal fossa' to fulfill the 1 major plus 4 or more minor criteria (1M+4m). In the validation set, the overall 1-year AD prevalence by the REACH was estimated as 12.3% (95% CI, 10.5%-14.2%), and the REACH showed a sensitivity of 75.2%, a specificity of 96.1%, and an error rate of 6.4%. The REACH demonstrated better diagnostic performance than the ISAAC in terms of the number of misclassification (10.0%). Conclusions: We propose the REACH as new full, questionnaire-based diagnostic criteria for childhood AD in epidemiological surveys. Further studies are warranted to validate the REACH in different populations or countries in the context of large-scale, epidemiological surveys.

AB - Purpose: Questionnaire-based diagnostic criteria for atopic dermatitis (AD) have been proposed to detect the major group of AD with flexural dermatitis. We aimed to develop novel, questionnaire-based diagnostic criteria for childhood AD, which can detect more comprehensive AD including non-flexural type. Methods: The draft version of questionnaire to detect childhood AD was prepared to be used for preliminary hospital- (n=1,756) and community-based (n=1,320) surveys. From analysis, the Reliable Estimation of Atopic dermatitis of ChildHood (REACH) was derived and verified in derivation (n=129) and validation (n=191) sets by community-based surveys. Results: The REACH consists of 11 questions including 2 major and 9 minor criteria. AD is diagnosed as the major group of 'eczema on the antecubital or popliteal fossa' to fulfill the 2 major criteria (2M), and the minor group of 'eczema on the non-antecubital or popliteal fossa' to fulfill the 1 major plus 4 or more minor criteria (1M+4m). In the validation set, the overall 1-year AD prevalence by the REACH was estimated as 12.3% (95% CI, 10.5%-14.2%), and the REACH showed a sensitivity of 75.2%, a specificity of 96.1%, and an error rate of 6.4%. The REACH demonstrated better diagnostic performance than the ISAAC in terms of the number of misclassification (10.0%). Conclusions: We propose the REACH as new full, questionnaire-based diagnostic criteria for childhood AD in epidemiological surveys. Further studies are warranted to validate the REACH in different populations or countries in the context of large-scale, epidemiological surveys.

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