Introduction to single-cell dna methylation profiling methods

Jongseong Ahn, Sunghoon Heo, Jihyun Lee, Duhee Bang

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

DNA methylation is an epigenetic mechanism that is related to mammalian cellular differentiation, gene expression regulation, and disease. In several studies, DNA methylation has been identified as an effective marker to identify differences between cells. In this review, we introduce single-cell DNA-methylation profiling methods, including experimental strategies and approaches to computational data analysis. Furthermore, the blind spots of the basic analysis and recent alternatives are briefly described. In addition, we introduce well-known applications and discuss future development.

Original languageEnglish
Article number1013
JournalBiomolecules
Volume11
Issue number7
DOIs
Publication statusPublished - 2021 Jul

Bibliographical note

Funding Information:
Funding: This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MSIT; 2016M3A9B6948494); the Mid-career Researcher Program of the National Research Foundation (NRF) funded by the Korean government (MSIT; 2018R1A2A1A05079172); the National Research Foundation (NRF) funded by the Korean government (MSIT; 2021R1A2C2008490); and the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI18C2282, HI14C1277).

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

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