Invasive Pulmonary Aspergillosis After Solid Organ Transplantation

Diagnosis and Treatment Based on 28 Years of Transplantation Experience

M. K. Ju, D. J. Joo, S. J. Kim, H. K. Chang, M. S. Kim, S. I. Kim, YuSeun Kim

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Invasive pulmonary aspergillosis (IPA) is a serious and lethal complication among organ transplant recipients. This report described the clinical manifestations and treatment of IPA over a 28-year period. From January 1979 to December 2007, 3215 organ transplant patients (2954 kidney and 261 liver recipients) were enrolled in the study. Nine patients developed IPA (7 kidney and 2 liver recipients), yielding an incidence of 0.003% (9/3215). Five IPA patients (55.6%) were diagnosed by transbronchial lung biopsy or autopsy, and 3 (33.3%) by sputum culture study. One patient was diagnosed through clinical manifestations and observations of IPA characteristics on chest X ray. We used amphotericin B (n = 4; 44.4%), voriconazole (n = 2; 22.2%), or fluconazole (n = 1; 11.1%) as the primary antifungal agents, but 2 patients could not receive antifungal agents due to rapid disease progression and sequential mortality. This study showed a high mortality rate among IPA patients (55.6%; 5/9). Only patients who received early antifungal agent thereby after a prompt diagnosis recovered from IPA. This survival advantage warrants careful monitoring for invasive fungal infections after organ transplantation with immediate administration of antifungal agents or surgical intervention.

Original languageEnglish
Pages (from-to)375-378
Number of pages4
JournalTransplantation Proceedings
Volume41
Issue number1
DOIs
Publication statusPublished - 2009 Jan 1

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Invasive Pulmonary Aspergillosis
Organ Transplantation
Transplantation
Antifungal Agents
Therapeutics
Transplants
Kidney
Mortality
Fluconazole
Liver
Amphotericin B
Sputum
Disease Progression
Autopsy
Thorax
X-Rays
Biopsy
Lung
Survival
Incidence

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

Cite this

Ju, M. K. ; Joo, D. J. ; Kim, S. J. ; Chang, H. K. ; Kim, M. S. ; Kim, S. I. ; Kim, YuSeun. / Invasive Pulmonary Aspergillosis After Solid Organ Transplantation : Diagnosis and Treatment Based on 28 Years of Transplantation Experience. In: Transplantation Proceedings. 2009 ; Vol. 41, No. 1. pp. 375-378.
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Invasive Pulmonary Aspergillosis After Solid Organ Transplantation : Diagnosis and Treatment Based on 28 Years of Transplantation Experience. / Ju, M. K.; Joo, D. J.; Kim, S. J.; Chang, H. K.; Kim, M. S.; Kim, S. I.; Kim, YuSeun.

In: Transplantation Proceedings, Vol. 41, No. 1, 01.01.2009, p. 375-378.

Research output: Contribution to journalArticle

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