Invasive stratified mucin-producing carcinoma (ISMC) of the uterine cervix: Clinicopathological and molecular characteristics with special emphasis on the first description of consistent programmed death-ligand 1 (PD-l1) over-expression

Sangjoon Choi, So Woon Kim, Hyun Soo Kim

Research output: Contribution to journalReview articlepeer-review

Abstract

Background/Aim: Invasive stratified mucin-producing carcinoma (ISMC) of the uterine cervix has been reported to be more aggressive than other subtypes of endocervical adenocarcinoma. We investigated the clinicopathological and molecular characteristics of eight ISMCs. Patients and Methods: We reviewed the electronic medical records and pathology slides of eight patients with ISMC and conducted programmed death-ligand 1 (PD-L1) immunostaining and targeted sequencing. Results: The patients were between 31 and 54 years. Six tumors were pure ISMCs, and two showed co-existing squamous cell carcinoma and usual-type endocervical adenocarcinoma. Lymph node metastases were detected in three cases. Three patients developed distant metastases to the adnexa, lungs, inguinal lymph nodes, and small intestine. Two patients experienced disease progression, and three developed postoperative local recurrences. All tumors showed PD-L1 over-expression, with a mean combined positive score of 73.8 (range=30-100). One tumor harbored erb-b2 receptor tyrosine kinase 2 amplification. Conclusion: ISMC of the uterine cervix exhibits a high risk of recurrence, metastasis, and resistance to chemoradiation therapy. PD-L1 overexpression was consistently observed in all ISMCs. This finding raises the possibility that patients with ISMC may benefit from PD-L1 immunotherapy.

Original languageEnglish
Pages (from-to)685-698
Number of pages14
JournalCancer Genomics and Proteomics
Volume18
Issue number5
DOIs
Publication statusPublished - 2021 Oct

Bibliographical note

Publisher Copyright:
© 2021 International Institute of Anticancer Research. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cancer Research

Fingerprint

Dive into the research topics of 'Invasive stratified mucin-producing carcinoma (ISMC) of the uterine cervix: Clinicopathological and molecular characteristics with special emphasis on the first description of consistent programmed death-ligand 1 (PD-l1) over-expression'. Together they form a unique fingerprint.

Cite this