Inverse association between glycated albumin and insulin secretory function may explain higher levels of glycated albumin in subjects with longer duration of diabetes

Yong Ho Lee, Mi Hyang Kown, Kwang Joon Kim, Eun Young Lee, Daham Kim, Byung Wan Lee, Eun Seok Kang, Bong Soo Cha, Hyun Chul Lee

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Glycated albumin (GA) has been increasingly used as a reliable index for short-Term glycemic monitoring, and is inversely associated with b-cell function. Because the pathophysiologic nature of type 2 diabetes (T2D) is characterized by progressive decline in insulin secretion, the aim was to determine whether GA levels were affected by diabetes duration in subjects with T2D. Methods: To minimize the effect of glucose variability on GA, subjects with stably maintained HbA1c levels of ,0.5% fluctuation across 6 months of measurements were included. Patients with newly diagnosed T2D (n = 1059) and with duration.1 year (n = 781) were recruited and categorized as New-T2D and Old-T2D, respectively. Biochemical, glycemic, and C-peptide parameters were measured. Results: GA levels were significantly elevated in HbA1c-matched Old-T2D subjects compared to New-T2D subjects. Duration of diabetes was positively correlated with GA, whereas a negative relationship was found with C-peptide increment (DCpeptide). Among insulin secretory indices, dynamic parameters such as DC-peptide were inversely related to GA (r =20.42, p,0.001). Multiple linear regression analyses showed that duration of diabetes was associated with GA (standardized b coefficient [STDb] = 0.05, p,0.001), but not with HbA1c (STDb = 0.04, p,0.095). This association disappeared after additional adjustment with DC-peptide (STDb = 0.02, p = 0.372), suggesting that b-cell function might be a linking factor of close relationship between duration of diabetes and GA values. Conclusions: The present study showed that GA levels were significantly increased in subjects with longer duration T2D and with decreased insulin secretory function. Additional caution should be taken when interpreting GA values to assess glycemic control status in these individuals.

Original languageEnglish
Article numbere0108772
JournalPloS one
Volume9
Issue number9
DOIs
Publication statusPublished - 2014 Sep

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Medical problems
albumins
diabetes
insulin
noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus
duration
glycohemoglobin
peptides
C-Peptide
Insulin
glycosylated serum albumin
glycosylated insulin
glycemic control
Peptides
insulin secretion
Linear Models
Linear regression
Regression Analysis
cells

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Lee, Yong Ho ; Kown, Mi Hyang ; Kim, Kwang Joon ; Lee, Eun Young ; Kim, Daham ; Lee, Byung Wan ; Kang, Eun Seok ; Cha, Bong Soo ; Lee, Hyun Chul. / Inverse association between glycated albumin and insulin secretory function may explain higher levels of glycated albumin in subjects with longer duration of diabetes. In: PloS one. 2014 ; Vol. 9, No. 9.
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abstract = "Background: Glycated albumin (GA) has been increasingly used as a reliable index for short-Term glycemic monitoring, and is inversely associated with b-cell function. Because the pathophysiologic nature of type 2 diabetes (T2D) is characterized by progressive decline in insulin secretion, the aim was to determine whether GA levels were affected by diabetes duration in subjects with T2D. Methods: To minimize the effect of glucose variability on GA, subjects with stably maintained HbA1c levels of ,0.5{\%} fluctuation across 6 months of measurements were included. Patients with newly diagnosed T2D (n = 1059) and with duration.1 year (n = 781) were recruited and categorized as New-T2D and Old-T2D, respectively. Biochemical, glycemic, and C-peptide parameters were measured. Results: GA levels were significantly elevated in HbA1c-matched Old-T2D subjects compared to New-T2D subjects. Duration of diabetes was positively correlated with GA, whereas a negative relationship was found with C-peptide increment (DCpeptide). Among insulin secretory indices, dynamic parameters such as DC-peptide were inversely related to GA (r =20.42, p,0.001). Multiple linear regression analyses showed that duration of diabetes was associated with GA (standardized b coefficient [STDb] = 0.05, p,0.001), but not with HbA1c (STDb = 0.04, p,0.095). This association disappeared after additional adjustment with DC-peptide (STDb = 0.02, p = 0.372), suggesting that b-cell function might be a linking factor of close relationship between duration of diabetes and GA values. Conclusions: The present study showed that GA levels were significantly increased in subjects with longer duration T2D and with decreased insulin secretory function. Additional caution should be taken when interpreting GA values to assess glycemic control status in these individuals.",
author = "Lee, {Yong Ho} and Kown, {Mi Hyang} and Kim, {Kwang Joon} and Lee, {Eun Young} and Daham Kim and Lee, {Byung Wan} and Kang, {Eun Seok} and Cha, {Bong Soo} and Lee, {Hyun Chul}",
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Inverse association between glycated albumin and insulin secretory function may explain higher levels of glycated albumin in subjects with longer duration of diabetes. / Lee, Yong Ho; Kown, Mi Hyang; Kim, Kwang Joon; Lee, Eun Young; Kim, Daham; Lee, Byung Wan; Kang, Eun Seok; Cha, Bong Soo; Lee, Hyun Chul.

In: PloS one, Vol. 9, No. 9, e0108772, 09.2014.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Inverse association between glycated albumin and insulin secretory function may explain higher levels of glycated albumin in subjects with longer duration of diabetes

AU - Lee, Yong Ho

AU - Kown, Mi Hyang

AU - Kim, Kwang Joon

AU - Lee, Eun Young

AU - Kim, Daham

AU - Lee, Byung Wan

AU - Kang, Eun Seok

AU - Cha, Bong Soo

AU - Lee, Hyun Chul

PY - 2014/9

Y1 - 2014/9

N2 - Background: Glycated albumin (GA) has been increasingly used as a reliable index for short-Term glycemic monitoring, and is inversely associated with b-cell function. Because the pathophysiologic nature of type 2 diabetes (T2D) is characterized by progressive decline in insulin secretion, the aim was to determine whether GA levels were affected by diabetes duration in subjects with T2D. Methods: To minimize the effect of glucose variability on GA, subjects with stably maintained HbA1c levels of ,0.5% fluctuation across 6 months of measurements were included. Patients with newly diagnosed T2D (n = 1059) and with duration.1 year (n = 781) were recruited and categorized as New-T2D and Old-T2D, respectively. Biochemical, glycemic, and C-peptide parameters were measured. Results: GA levels were significantly elevated in HbA1c-matched Old-T2D subjects compared to New-T2D subjects. Duration of diabetes was positively correlated with GA, whereas a negative relationship was found with C-peptide increment (DCpeptide). Among insulin secretory indices, dynamic parameters such as DC-peptide were inversely related to GA (r =20.42, p,0.001). Multiple linear regression analyses showed that duration of diabetes was associated with GA (standardized b coefficient [STDb] = 0.05, p,0.001), but not with HbA1c (STDb = 0.04, p,0.095). This association disappeared after additional adjustment with DC-peptide (STDb = 0.02, p = 0.372), suggesting that b-cell function might be a linking factor of close relationship between duration of diabetes and GA values. Conclusions: The present study showed that GA levels were significantly increased in subjects with longer duration T2D and with decreased insulin secretory function. Additional caution should be taken when interpreting GA values to assess glycemic control status in these individuals.

AB - Background: Glycated albumin (GA) has been increasingly used as a reliable index for short-Term glycemic monitoring, and is inversely associated with b-cell function. Because the pathophysiologic nature of type 2 diabetes (T2D) is characterized by progressive decline in insulin secretion, the aim was to determine whether GA levels were affected by diabetes duration in subjects with T2D. Methods: To minimize the effect of glucose variability on GA, subjects with stably maintained HbA1c levels of ,0.5% fluctuation across 6 months of measurements were included. Patients with newly diagnosed T2D (n = 1059) and with duration.1 year (n = 781) were recruited and categorized as New-T2D and Old-T2D, respectively. Biochemical, glycemic, and C-peptide parameters were measured. Results: GA levels were significantly elevated in HbA1c-matched Old-T2D subjects compared to New-T2D subjects. Duration of diabetes was positively correlated with GA, whereas a negative relationship was found with C-peptide increment (DCpeptide). Among insulin secretory indices, dynamic parameters such as DC-peptide were inversely related to GA (r =20.42, p,0.001). Multiple linear regression analyses showed that duration of diabetes was associated with GA (standardized b coefficient [STDb] = 0.05, p,0.001), but not with HbA1c (STDb = 0.04, p,0.095). This association disappeared after additional adjustment with DC-peptide (STDb = 0.02, p = 0.372), suggesting that b-cell function might be a linking factor of close relationship between duration of diabetes and GA values. Conclusions: The present study showed that GA levels were significantly increased in subjects with longer duration T2D and with decreased insulin secretory function. Additional caution should be taken when interpreting GA values to assess glycemic control status in these individuals.

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