Inverse association between total bilirubin and metabolic syndrome in rural Korean women

Kyung Min Kwon, Jin Hwa Kam, Min Young Kim, Moonyoung Kim, Choon Hee Chung, Jong Koo Kim, John A. Linton, Aeyong Eom, Sangbaek Koh, Hee Taik Kang

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background: Chronic inflammation and oxidative stress are associated with the development of metabolic syndrome (MetS). Bilirubin is an antioxidant and has a protective effect against cardiovascular disease (CVD). The purpose of this study was to examine the association between total bilirubin levels and the prevalence of MetS in rural Korean women. Methods: This cross-sectional study included 5,266 women (>40 years) enrolled in the Korean Genomic Rural Cohort (KGRC). MetS was defined using the American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI) guidelines. Total bilirubin levels were categorized into quartiles. Results: Subjects in the upper quartiles of total bilirubin were younger and had lower waist circumferences, systolic blood pressure, and triglyceride levels and higher high-density lipoprotein cholesterol (HDL-C) concentrations. The overall prevalence of MetS was 39.0%. When the participants were categorized into quartiles by total bilirubin level, the prevalence of MetS according to increasing total bilirubin quartiles was 47.9%, 41.2%, 34.3%, and 32.7%, respectively. By comparison to the lowest quartile of total bilirubin (<0.61 mg/dL), the odds ratio (OR) (95% confidence interval [CI]) for MetS in the highest quartile of total bilirubin (≥0.94 mg/dL) was 0.63 (0.52-0.77) after adjusting for menopausal status, C-reactive protein (CRP) levels, insulin resistance, and other covariates. Conclusions: Total bilirubin level appears to be inversely associated with the prevalence of MetS in rural Korean women >40 years of age in the KGRC, even after adjusting for risk factors of MetS, including body mass index (BMI), menopausal status, CRP levels, and homeostasis model assessment of insulin resistance (HOMA-IR).

Original languageEnglish
Pages (from-to)963-969
Number of pages7
JournalJournal of Women's Health
Volume20
Issue number6
DOIs
Publication statusPublished - 2011 Jun 1

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Bilirubin
Blood Pressure
National Heart, Lung, and Blood Institute (U.S.)
Waist Circumference
HDL Cholesterol
Insulin Resistance
Triglycerides
Oxidative Stress
Body Mass Index
Homeostasis
Cardiovascular Diseases
Cross-Sectional Studies
Antioxidants
Guidelines
Inflammation

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Kwon, Kyung Min ; Kam, Jin Hwa ; Kim, Min Young ; Kim, Moonyoung ; Chung, Choon Hee ; Kim, Jong Koo ; Linton, John A. ; Eom, Aeyong ; Koh, Sangbaek ; Kang, Hee Taik. / Inverse association between total bilirubin and metabolic syndrome in rural Korean women. In: Journal of Women's Health. 2011 ; Vol. 20, No. 6. pp. 963-969.
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abstract = "Background: Chronic inflammation and oxidative stress are associated with the development of metabolic syndrome (MetS). Bilirubin is an antioxidant and has a protective effect against cardiovascular disease (CVD). The purpose of this study was to examine the association between total bilirubin levels and the prevalence of MetS in rural Korean women. Methods: This cross-sectional study included 5,266 women (>40 years) enrolled in the Korean Genomic Rural Cohort (KGRC). MetS was defined using the American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI) guidelines. Total bilirubin levels were categorized into quartiles. Results: Subjects in the upper quartiles of total bilirubin were younger and had lower waist circumferences, systolic blood pressure, and triglyceride levels and higher high-density lipoprotein cholesterol (HDL-C) concentrations. The overall prevalence of MetS was 39.0{\%}. When the participants were categorized into quartiles by total bilirubin level, the prevalence of MetS according to increasing total bilirubin quartiles was 47.9{\%}, 41.2{\%}, 34.3{\%}, and 32.7{\%}, respectively. By comparison to the lowest quartile of total bilirubin (<0.61 mg/dL), the odds ratio (OR) (95{\%} confidence interval [CI]) for MetS in the highest quartile of total bilirubin (≥0.94 mg/dL) was 0.63 (0.52-0.77) after adjusting for menopausal status, C-reactive protein (CRP) levels, insulin resistance, and other covariates. Conclusions: Total bilirubin level appears to be inversely associated with the prevalence of MetS in rural Korean women >40 years of age in the KGRC, even after adjusting for risk factors of MetS, including body mass index (BMI), menopausal status, CRP levels, and homeostasis model assessment of insulin resistance (HOMA-IR).",
author = "Kwon, {Kyung Min} and Kam, {Jin Hwa} and Kim, {Min Young} and Moonyoung Kim and Chung, {Choon Hee} and Kim, {Jong Koo} and Linton, {John A.} and Aeyong Eom and Sangbaek Koh and Kang, {Hee Taik}",
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Inverse association between total bilirubin and metabolic syndrome in rural Korean women. / Kwon, Kyung Min; Kam, Jin Hwa; Kim, Min Young; Kim, Moonyoung; Chung, Choon Hee; Kim, Jong Koo; Linton, John A.; Eom, Aeyong; Koh, Sangbaek; Kang, Hee Taik.

In: Journal of Women's Health, Vol. 20, No. 6, 01.06.2011, p. 963-969.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Inverse association between total bilirubin and metabolic syndrome in rural Korean women

AU - Kwon, Kyung Min

AU - Kam, Jin Hwa

AU - Kim, Min Young

AU - Kim, Moonyoung

AU - Chung, Choon Hee

AU - Kim, Jong Koo

AU - Linton, John A.

AU - Eom, Aeyong

AU - Koh, Sangbaek

AU - Kang, Hee Taik

PY - 2011/6/1

Y1 - 2011/6/1

N2 - Background: Chronic inflammation and oxidative stress are associated with the development of metabolic syndrome (MetS). Bilirubin is an antioxidant and has a protective effect against cardiovascular disease (CVD). The purpose of this study was to examine the association between total bilirubin levels and the prevalence of MetS in rural Korean women. Methods: This cross-sectional study included 5,266 women (>40 years) enrolled in the Korean Genomic Rural Cohort (KGRC). MetS was defined using the American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI) guidelines. Total bilirubin levels were categorized into quartiles. Results: Subjects in the upper quartiles of total bilirubin were younger and had lower waist circumferences, systolic blood pressure, and triglyceride levels and higher high-density lipoprotein cholesterol (HDL-C) concentrations. The overall prevalence of MetS was 39.0%. When the participants were categorized into quartiles by total bilirubin level, the prevalence of MetS according to increasing total bilirubin quartiles was 47.9%, 41.2%, 34.3%, and 32.7%, respectively. By comparison to the lowest quartile of total bilirubin (<0.61 mg/dL), the odds ratio (OR) (95% confidence interval [CI]) for MetS in the highest quartile of total bilirubin (≥0.94 mg/dL) was 0.63 (0.52-0.77) after adjusting for menopausal status, C-reactive protein (CRP) levels, insulin resistance, and other covariates. Conclusions: Total bilirubin level appears to be inversely associated with the prevalence of MetS in rural Korean women >40 years of age in the KGRC, even after adjusting for risk factors of MetS, including body mass index (BMI), menopausal status, CRP levels, and homeostasis model assessment of insulin resistance (HOMA-IR).

AB - Background: Chronic inflammation and oxidative stress are associated with the development of metabolic syndrome (MetS). Bilirubin is an antioxidant and has a protective effect against cardiovascular disease (CVD). The purpose of this study was to examine the association between total bilirubin levels and the prevalence of MetS in rural Korean women. Methods: This cross-sectional study included 5,266 women (>40 years) enrolled in the Korean Genomic Rural Cohort (KGRC). MetS was defined using the American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI) guidelines. Total bilirubin levels were categorized into quartiles. Results: Subjects in the upper quartiles of total bilirubin were younger and had lower waist circumferences, systolic blood pressure, and triglyceride levels and higher high-density lipoprotein cholesterol (HDL-C) concentrations. The overall prevalence of MetS was 39.0%. When the participants were categorized into quartiles by total bilirubin level, the prevalence of MetS according to increasing total bilirubin quartiles was 47.9%, 41.2%, 34.3%, and 32.7%, respectively. By comparison to the lowest quartile of total bilirubin (<0.61 mg/dL), the odds ratio (OR) (95% confidence interval [CI]) for MetS in the highest quartile of total bilirubin (≥0.94 mg/dL) was 0.63 (0.52-0.77) after adjusting for menopausal status, C-reactive protein (CRP) levels, insulin resistance, and other covariates. Conclusions: Total bilirubin level appears to be inversely associated with the prevalence of MetS in rural Korean women >40 years of age in the KGRC, even after adjusting for risk factors of MetS, including body mass index (BMI), menopausal status, CRP levels, and homeostasis model assessment of insulin resistance (HOMA-IR).

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U2 - 10.1089/jwh.2010.2453

DO - 10.1089/jwh.2010.2453

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