Inverse relationship between bioavailable testosterone and subclinical coronary artery calcification in non-obese Korean men

Byoung Jin Park, Jae Yong Shim, Yong Jae Lee, Jung Hyun Lee, Hye Ree Lee

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Although low testosterone levels in men have been associated with high risk for cardiovascular disease, little is known about the association between male sex hormones and subclinical coronary disease in men with apparently low cardiometabolic risk. This study was performed to investigate the association between male sex hormones and subclinical coronary artery calcification measured as coronary calcium score in non-obese Korean men. We examined the relationship of total testosterone, sex hormone-binding globulin, bioavailable testosterone and free testosterone with coronary calcium score in 291 non-obese Korean men (mean age: 52.8±9.3 years) not having a history of cardiovascular disease. Using multiple linear regression, we evaluated associations between log (sex hormone) levels and log (coronary calcium score) after adjusting for confounding variables in 105 men with some degree of coronary calcification defined as coronary calcium score ≥ 1. In multiple linear regression analysis, bioavailable testosterone was inversely associated with coronary calcium score (P = 0.046) after adjusting for age, body mass index, smoking status, alcohol consumption, regular exercise, mean blood pressure, resting heart rate, C-reactive protein, fasting plasma glucose, total cholesterol, triglyceride, high-density lipoprotein (HDL) cholesterol, hypertension medication and hyperlipidemia medication, whereas total testosterone, sex hormone-binding globulin and free testosterone were not (P = 0.674, P = 0.121 and P = 0.102, respectively). Our findings indicate that bioavailable testosterone is inversely associated with the degree of subclinical coronary artery calcification in non-obese men.

Original languageEnglish
Pages (from-to)612-615
Number of pages4
JournalAsian Journal of Andrology
Volume14
Issue number4
DOIs
Publication statusPublished - 2012 Jul 1

All Science Journal Classification (ASJC) codes

  • Urology

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