Inverse relationship between hepatic steatosis and alanine aminotransferase with sex hormone-binding globulin in men

In Ho Seo, Hyung Bin Lee, Shinhye Kim, Yongjae Lee, Dong Hyuk Jung

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Purpose: Sex hormone-binding globulin (SHBG) is a serum glycoprotein produced predominantly in hepatocytes. As such, the synthesis of SHBG could be associated with liver function and metabolic syndrome. Alanine aminotransferase (ALT) levels could reflect hepatocellular injury and insulin resistance; however, the relationship between hepatic steatosis and ALT with SHBG has not been investigated in humans. The objective of this study was to investigate the associations between SHBG and hepatocyte damage among Korean male patients with hepatic steatosis enrolled in a health examination program. Materials and Methods: We performed a retrospective cross-sectional study with 922 participants who underwent routine health examinations. A total of 922 men with or without hepatic steatosis were divided into three groups. We analyzed the risk of lower serum SHBG levels with or without elevated serum ALT levels using odds ratios with 95% confidence intervals (CIs). Results: A significantly increased risk of lower serum SHBG level was observed in the group with hepatic steatosis and ALT elevation (95% CI 1.591-4.681). Conclusion: In men with hepatic steatosis, we found that elevated serum ALT levels were associated with lower serum SHBG levels. This finding suggests that subjects with both hepatic steatosis and increased ALT should be considered to have low levels of SHBG.

Original languageEnglish
Pages (from-to)731-736
Number of pages6
JournalYonsei medical journal
Volume58
Issue number4
DOIs
Publication statusPublished - 2017 Jul 1

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Sex Hormone-Binding Globulin
Alanine Transaminase
Liver
Serum Globulins
Hepatocytes
Serum
Confidence Intervals
Health
Insulin Resistance
Glycoproteins
Cross-Sectional Studies
Odds Ratio
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Seo, In Ho ; Lee, Hyung Bin ; Kim, Shinhye ; Lee, Yongjae ; Jung, Dong Hyuk. / Inverse relationship between hepatic steatosis and alanine aminotransferase with sex hormone-binding globulin in men. In: Yonsei medical journal. 2017 ; Vol. 58, No. 4. pp. 731-736.
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abstract = "Purpose: Sex hormone-binding globulin (SHBG) is a serum glycoprotein produced predominantly in hepatocytes. As such, the synthesis of SHBG could be associated with liver function and metabolic syndrome. Alanine aminotransferase (ALT) levels could reflect hepatocellular injury and insulin resistance; however, the relationship between hepatic steatosis and ALT with SHBG has not been investigated in humans. The objective of this study was to investigate the associations between SHBG and hepatocyte damage among Korean male patients with hepatic steatosis enrolled in a health examination program. Materials and Methods: We performed a retrospective cross-sectional study with 922 participants who underwent routine health examinations. A total of 922 men with or without hepatic steatosis were divided into three groups. We analyzed the risk of lower serum SHBG levels with or without elevated serum ALT levels using odds ratios with 95{\%} confidence intervals (CIs). Results: A significantly increased risk of lower serum SHBG level was observed in the group with hepatic steatosis and ALT elevation (95{\%} CI 1.591-4.681). Conclusion: In men with hepatic steatosis, we found that elevated serum ALT levels were associated with lower serum SHBG levels. This finding suggests that subjects with both hepatic steatosis and increased ALT should be considered to have low levels of SHBG.",
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Inverse relationship between hepatic steatosis and alanine aminotransferase with sex hormone-binding globulin in men. / Seo, In Ho; Lee, Hyung Bin; Kim, Shinhye; Lee, Yongjae; Jung, Dong Hyuk.

In: Yonsei medical journal, Vol. 58, No. 4, 01.07.2017, p. 731-736.

Research output: Contribution to journalArticle

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