Investigating photodynamic efficiency of tumor targeted nanoparticular photosensitizer using microfluidic chips

X. Lou, G. Kim, Y. Koo Lee, R. Kopelman, Euisik Yoon

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Citations (Scopus)

Abstract

We present a new high-throughput assay for screening photodynamic efficiency of nanodrugs in a microfluidic chip. Surface engineered nanoparticles are applied to multiple cell lines for evaluating their specificity on target cancer cells. Using a microfluidic gradient generation network in the fabricated prototype chip, photodynamic efficiency for various nanodrug doses was simultaneously evaluated in one single screening. Temporal control of drug injection into the microfluidic channels provides a precise control of drug treatment time on target cancer cells, which is one of critical parameters in PDT treatment. Using the proposed microfluidic assays, we successfully demonstrated the nanodrug s photodynamic efficacy testing for different target cell types, drug doses and treatment protocols.

Original languageEnglish
Title of host publication15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Pages2058-2060
Number of pages3
Publication statusPublished - 2011 Dec 1
Event15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States
Duration: 2011 Oct 22011 Oct 6

Publication series

Name15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Volume3

Other

Other15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
CountryUnited States
CitySeattle, WA
Period11/10/211/10/6

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

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  • Cite this

    Lou, X., Kim, G., Koo Lee, Y., Kopelman, R., & Yoon, E. (2011). Investigating photodynamic efficiency of tumor targeted nanoparticular photosensitizer using microfluidic chips. In 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 (pp. 2058-2060). (15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011; Vol. 3).