Investigation into the effects of mosapride on motility of guinea pig stomach, ileum, and colon

Sang Won Ji, HyoJin Park, Jun Sik Cho, Jung Hyun Lim, Sang In Lee

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Mosapride citrate (Mosapride) is a new prokinetic agent that enhances the gastrointestinal (GI) motility by stimulation of 5-HT4 receptors. This agent stimulates acetylcholine release from enteric cholinergic neurons in the GI wall. It was reported in several studies that mosapride selectively enhanced the upper, but not lower, GI motor activity. However, in these studies other 5-HT4 receptor agonists exerted stimulating effects on the motility of the colon. Moreover, it is well known that the receptors of 5-HT4 are also located in the colon. The purpose of this study was to estimate the effect of mosapride on the motility of the stomach, ileum and colon in the guinea pig and to investigate whether or not mosapride influenced the colonic motility. Mosapride significantly increased the amplitude of the contraction waves in the guinea pig stomach by electrical stimulation. In addition, it significantly increased the number of peaks, the area under the curve and the propagation velocity of the peristaltic contraction of the guinea pig ileum in a concentration dependent fashion. Mosapride also significantly shortened the transit time of the guinea pig colon. Accordingly, we concluded that mosapride exerted prokinetic effect on the entire GI tract of the guinea pig. Based on the possibility of similar results in humans, we suggest the potential use of mosapride for lower GI motor disorders such as constipation and upper GI motor disorders such as gastroesophageal reflex disease or gastroparesis.

Original languageEnglish
Pages (from-to)653-664
Number of pages12
JournalYonsei Medical Journal
Volume44
Issue number4
DOIs
Publication statusPublished - 2003 Aug 30

Fingerprint

Ileum
Stomach
Guinea Pigs
Colon
Receptors, Serotonin, 5-HT4
Serotonin 5-HT4 Receptor Agonists
Gastroparesis
mosapride
Cholinergic Neurons
Gastrointestinal Motility
Constipation
Cholinergic Agents
Electric Stimulation
Area Under Curve
Reflex
Gastrointestinal Tract
Motor Activity

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Ji, Sang Won ; Park, HyoJin ; Cho, Jun Sik ; Lim, Jung Hyun ; Lee, Sang In. / Investigation into the effects of mosapride on motility of guinea pig stomach, ileum, and colon. In: Yonsei Medical Journal. 2003 ; Vol. 44, No. 4. pp. 653-664.
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Investigation into the effects of mosapride on motility of guinea pig stomach, ileum, and colon. / Ji, Sang Won; Park, HyoJin; Cho, Jun Sik; Lim, Jung Hyun; Lee, Sang In.

In: Yonsei Medical Journal, Vol. 44, No. 4, 30.08.2003, p. 653-664.

Research output: Contribution to journalArticle

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