Investigation of bone formation using non-crystalline calcium phosphate glass in beagle dogs

Y. K. Lee, H. S. Kim, K. S. Cho, K. N. Kim, S. H. Choi

Research output: Contribution to journalConference article

3 Citations (Scopus)

Abstract

The purpose of this study was to explore non-crystalline calcium phosphate glass as potential biomaterials in the regeneration of periodontal tissue. We prepared calcium phosphate glass with Ca/P ratio of 0.6 using the system CaO-CaF2-P2O5-MgO-ZnO and subsequent milling to 0.08∼555.7 μm (average size; 167.95 μm). In vivo evaluation of the prepared glass was investigated using beagle dogs by 1-wall intrabony defect model. They were sacrificed after 8 weeks and alanlyzed histomorphometrically. No root resorption or ankylosis were observed in the experimental group. It can be examined that the prepared glass were effective in cementum regeneration in the early healing stage by Mann-Whitney U test, while there were no statistical significant difference between experimental and control group in the amounts of junctional epithelium migration, connective tissue adhesion, and alveolar bone regeneration. Further study is required to control the flowability as well as reduce the absorption rate in vivo.

Original languageEnglish
Pages (from-to)391-394
Number of pages4
JournalKey Engineering Materials
Volume240-242
Publication statusPublished - 2003 Apr 21
EventProceedings of the 15th International Symposium on Ceramics in Medicine; The Annual Meeting of the International Society for Ceramics in Medicine - Sydney, NSW, Australia
Duration: 2002 Dec 42002 Dec 8

Fingerprint

Calcium phosphate
Bone
Glass
phosphorus pentoxide
Tissue
Biocompatible Materials
Biomaterials
Adhesion
Defects
calcium phosphate

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Lee, Y. K. ; Kim, H. S. ; Cho, K. S. ; Kim, K. N. ; Choi, S. H. / Investigation of bone formation using non-crystalline calcium phosphate glass in beagle dogs. In: Key Engineering Materials. 2003 ; Vol. 240-242. pp. 391-394.
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Investigation of bone formation using non-crystalline calcium phosphate glass in beagle dogs. / Lee, Y. K.; Kim, H. S.; Cho, K. S.; Kim, K. N.; Choi, S. H.

In: Key Engineering Materials, Vol. 240-242, 21.04.2003, p. 391-394.

Research output: Contribution to journalConference article

TY - JOUR

T1 - Investigation of bone formation using non-crystalline calcium phosphate glass in beagle dogs

AU - Lee, Y. K.

AU - Kim, H. S.

AU - Cho, K. S.

AU - Kim, K. N.

AU - Choi, S. H.

PY - 2003/4/21

Y1 - 2003/4/21

N2 - The purpose of this study was to explore non-crystalline calcium phosphate glass as potential biomaterials in the regeneration of periodontal tissue. We prepared calcium phosphate glass with Ca/P ratio of 0.6 using the system CaO-CaF2-P2O5-MgO-ZnO and subsequent milling to 0.08∼555.7 μm (average size; 167.95 μm). In vivo evaluation of the prepared glass was investigated using beagle dogs by 1-wall intrabony defect model. They were sacrificed after 8 weeks and alanlyzed histomorphometrically. No root resorption or ankylosis were observed in the experimental group. It can be examined that the prepared glass were effective in cementum regeneration in the early healing stage by Mann-Whitney U test, while there were no statistical significant difference between experimental and control group in the amounts of junctional epithelium migration, connective tissue adhesion, and alveolar bone regeneration. Further study is required to control the flowability as well as reduce the absorption rate in vivo.

AB - The purpose of this study was to explore non-crystalline calcium phosphate glass as potential biomaterials in the regeneration of periodontal tissue. We prepared calcium phosphate glass with Ca/P ratio of 0.6 using the system CaO-CaF2-P2O5-MgO-ZnO and subsequent milling to 0.08∼555.7 μm (average size; 167.95 μm). In vivo evaluation of the prepared glass was investigated using beagle dogs by 1-wall intrabony defect model. They were sacrificed after 8 weeks and alanlyzed histomorphometrically. No root resorption or ankylosis were observed in the experimental group. It can be examined that the prepared glass were effective in cementum regeneration in the early healing stage by Mann-Whitney U test, while there were no statistical significant difference between experimental and control group in the amounts of junctional epithelium migration, connective tissue adhesion, and alveolar bone regeneration. Further study is required to control the flowability as well as reduce the absorption rate in vivo.

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M3 - Conference article

AN - SCOPUS:0037246969

VL - 240-242

SP - 391

EP - 394

JO - Key Engineering Materials

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