Investigation of Keratinizing Squamous Cell Carcinoma of the Tongue Using Terahertz Reflection Imaging

Young Bin Ji, Jung Min Kim, Young Han Lee, Yuna Choi, Da Hee Kim, Yong Min Huh, Seung Jae Oh, Yoon Woo Koh, Jin Suck Suh

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


We investigated the feasibility of using terahertz (THz) reflection imaging to detect keratinizing squamous cell carcinoma (SCC) of the tongue. Four fresh keratinizing SCC tissues were studied, which had been surgically resected. All of the keratinizing SCCs were well distinguished from normal healthy tissues. We showed that the tumor regions exhibited low THz reflection despite having higher water content than normal regions. The refractive indices and absorption coefficients were low in the tumor tissues despite the relatively high water content. Our results showed that there were dominant factors such as keratin pearls, other than the water content affecting the THz reflection signal.

Original languageEnglish
Pages (from-to)247-256
Number of pages10
JournalJournal of Infrared, Millimeter, and Terahertz Waves
Issue number2
Publication statusPublished - 2019 Feb 1

Bibliographical note

Funding Information:
Acknowledgments This work was supported by National Research Foundation of Korea (NRF) grant funded by the Korea government (MOE) (2016R1D1A1B03933168, NRF-2017R1A2B1010381); Korea Health Industry Development Institute (KHIDI) grant funded by the Ministry of Health & Welfare, Republic of Korea (HI16C0179); Technology Innovation Program funded By the Ministry of Trade, industry & Energy (MI, Korea) (10060136); KIST intramural funding grant (2E27270).

All Science Journal Classification (ASJC) codes

  • Radiation
  • Instrumentation
  • Condensed Matter Physics
  • Electrical and Electronic Engineering

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